Studies on abnormalities in serum intermediate density lipoproteins during maintenance hemodialysis

In order to investigate the abnormalities of intermediate-density lipoproteins (IDL) in patients on maintenance hemodialysis (HD), we determined the percentage chemical compositions and the apolipoprotein (apo) distributions of IDL using the single radial immuno diffusion method. Electrophoretic mobility and molecular size in IDL were also analyzed. All determinations were compared between HD and sex-or age-matched normal controls (C). 1) HD produced a significant increase in the total amounts of IDL 2) With respect to the chemical compositions of IDL in HD, there was a significant increase in total cholesterol and a tendency for increased protein, while there was a significant decrease in triglyceride and the cholesterol esterification ratio. 3) HD produced a significant increase in apo B and a significant decrease in apo C-II, C-III and E. 4) The electrophoretic migration and elution patterns of IDL showed similarities between HD and C.