The role of secondary hyperparathyroidism in hypertriglyceridemia in patients with chronic renal failure

This study was planned to evaluate the role of secondary hyperparathyroidism in the mechanism of hypertriglyceridemia seen in chronic renal failure (CRF). The incidence of hypertriglyceridemia was 48.2% in the patients with CRF, though that of hypercholesterolemia was low. In comparison with the dec...

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Veröffentlicht in:Jinko Toseki Kenkyukai kaishi. [Journal of the Dialysis Research Society 1984/10/31, Vol.17(5), pp.347-352
Hauptverfasser: Nishizawa, Yoshiki, Okui, Yasuyuki, Miki, Takami, Ohnishi, Yasuo, Morii, Hirotoshi, Hasegawa, Koichi, Okamoto, Teruo, Kikunami, Kiichiro, Matsushita, Yoshiki, Inoue, Takayuki, Inoue, Takashi
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container_end_page 352
container_issue 5
container_start_page 347
container_title Jinko Toseki Kenkyukai kaishi. [Journal of the Dialysis Research Society
container_volume 17
creator Nishizawa, Yoshiki
Okui, Yasuyuki
Miki, Takami
Ohnishi, Yasuo
Morii, Hirotoshi
Hasegawa, Koichi
Okamoto, Teruo
Kikunami, Kiichiro
Matsushita, Yoshiki
Inoue, Takayuki
Inoue, Takashi
description This study was planned to evaluate the role of secondary hyperparathyroidism in the mechanism of hypertriglyceridemia seen in chronic renal failure (CRF). The incidence of hypertriglyceridemia was 48.2% in the patients with CRF, though that of hypercholesterolemia was low. In comparison with the decreasing tendency of cholesterol after the initiation of hemodialysis (HD), hypertriglyceridemia was maintained over the course of HD in 30 patients who did not have previous calcitonin or vitamin D administration. With the same assay in these patients, there was a positive correlation between alkaline phosphatase and serum triglyceride. In two cases of hypertriglyceridemia out of 5 parathyroidectomized patients, it was shown that hypertriglyceridemia was improved after parathyroidectomy. In an experiment with partially nephrectomized (5/6) uremic rats, parathyroidectomy was effective in reducing the serum level of triglycerides (from 123±37mg/dl to 76±6mg/dl, p
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The incidence of hypertriglyceridemia was 48.2% in the patients with CRF, though that of hypercholesterolemia was low. In comparison with the decreasing tendency of cholesterol after the initiation of hemodialysis (HD), hypertriglyceridemia was maintained over the course of HD in 30 patients who did not have previous calcitonin or vitamin D administration. With the same assay in these patients, there was a positive correlation between alkaline phosphatase and serum triglyceride. In two cases of hypertriglyceridemia out of 5 parathyroidectomized patients, it was shown that hypertriglyceridemia was improved after parathyroidectomy. In an experiment with partially nephrectomized (5/6) uremic rats, parathyroidectomy was effective in reducing the serum level of triglycerides (from 123±37mg/dl to 76±6mg/dl, p&lt;0.05). 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title The role of secondary hyperparathyroidism in hypertriglyceridemia in patients with chronic renal failure
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