The role of secondary hyperparathyroidism in hypertriglyceridemia in patients with chronic renal failure

This study was planned to evaluate the role of secondary hyperparathyroidism in the mechanism of hypertriglyceridemia seen in chronic renal failure (CRF). The incidence of hypertriglyceridemia was 48.2% in the patients with CRF, though that of hypercholesterolemia was low. In comparison with the decreasing tendency of cholesterol after the initiation of hemodialysis (HD), hypertriglyceridemia was maintained over the course of HD in 30 patients who did not have previous calcitonin or vitamin D administration. With the same assay in these patients, there was a positive correlation between alkaline phosphatase and serum triglyceride. In two cases of hypertriglyceridemia out of 5 parathyroidectomized patients, it was shown that hypertriglyceridemia was improved after parathyroidectomy. In an experiment with partially nephrectomized (5/6) uremic rats, parathyroidectomy was effective in reducing the serum level of triglycerides (from 123±37mg/dl to 76±6mg/dl, p