Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection
We report here a case of a 37-year-old man with human immunodeficiency virus (HIV) infection followed by JC virus (JCV) infection and primary central nervous system lymphoma (PCNSL). The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. He had progressi...
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| Veröffentlicht in: | Journal of Clinical and Experimental Hematopathology 2014, Vol.54(3), pp.211-217 |
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| creator | Kawakami, Toru Sakai, Kaoko Mimura, Yuto Senoo, Yasushi Hirabayashi, Yukio Nakazawa, Hideyuki Koshihara, Hiroshi Oguchi, Kenya Takei, Yo-ichi Ohara, Shinji Watanabe, Nobuaki Nakazawa, Kou Oyanagi, Kiyomitsu Kitano, Kiyoshi |
| description | We report here a case of a 37-year-old man with human immunodeficiency virus (HIV) infection followed by JC virus (JCV) infection and primary central nervous system lymphoma (PCNSL). The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. He had progression of nervous symptoms and was diagnosed with progressive multifocal leukoencephalopathy (PML) clinically at the age of 36, when his CD4-positive lymphocyte counts ranged between 350 and 450/μl. Oral mefloquine, intravenous methylprednisolone pulse therapy, and intravenous immunoglobulin were not effective for the PML, and the patient entered a vegetative state. Brain biopsy revealed JCV infection without pathological findings of PML. Eight months after the clinical diagnosis of PML, he developed respiratory failure and brain magnetic resonance imaging revealed a mass lesion in the brain stem. The patient died 19 months after the diagnosis of PML. Autopsy findings were compatible with PCNSL. EBV-encoded small RNA-1-positive cells were not detected. We present a case of JCV-positive PCNSL with HIV infection complicated with clinical PML. |
| doi_str_mv | 10.3960/jslrt.54.211 |
| format | Article |
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The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. He had progression of nervous symptoms and was diagnosed with progressive multifocal leukoencephalopathy (PML) clinically at the age of 36, when his CD4-positive lymphocyte counts ranged between 350 and 450/μl. Oral mefloquine, intravenous methylprednisolone pulse therapy, and intravenous immunoglobulin were not effective for the PML, and the patient entered a vegetative state. Brain biopsy revealed JCV infection without pathological findings of PML. Eight months after the clinical diagnosis of PML, he developed respiratory failure and brain magnetic resonance imaging revealed a mass lesion in the brain stem. The patient died 19 months after the diagnosis of PML. Autopsy findings were compatible with PCNSL. EBV-encoded small RNA-1-positive cells were not detected. We present a case of JCV-positive PCNSL with HIV infection complicated with clinical PML.</description><identifier>ISSN: 1346-4280</identifier><identifier>EISSN: 1880-9952</identifier><identifier>DOI: 10.3960/jslrt.54.211</identifier><identifier>PMID: 25501112</identifier><language>eng</language><publisher>Japan: The Japanese Society for Lymphoreticular Tissue Research</publisher><subject>acquired immunodeficiency syndrome ; Adult ; Central Nervous System Diseases - pathology ; Central Nervous System Diseases - virology ; HIV infection ; HIV Infections - pathology ; HIV Infections - virology ; Humans ; JC Virus - isolation & purification ; Leukoencephalopathy, Progressive Multifocal - pathology ; Leukoencephalopathy, Progressive Multifocal - virology ; Lymphoma - pathology ; Lymphoma - virology ; Male ; primary central nervous system lymphoma ; progressive multifocal leukoencephalopathy</subject><ispartof>Journal of Clinical and Experimental Hematopathology, 2014, Vol.54(3), pp.211-217</ispartof><rights>2014 by The Japanese Society for Lymphoreticular Tissue Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-330a3788de5a473bdd8f71f8fd7ce8c4f573535514da074c8f2d87c42907662e3</citedby><cites>FETCH-LOGICAL-c372t-330a3788de5a473bdd8f71f8fd7ce8c4f573535514da074c8f2d87c42907662e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25501112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakami, Toru</creatorcontrib><creatorcontrib>Sakai, Kaoko</creatorcontrib><creatorcontrib>Mimura, Yuto</creatorcontrib><creatorcontrib>Senoo, Yasushi</creatorcontrib><creatorcontrib>Hirabayashi, Yukio</creatorcontrib><creatorcontrib>Nakazawa, Hideyuki</creatorcontrib><creatorcontrib>Koshihara, Hiroshi</creatorcontrib><creatorcontrib>Oguchi, Kenya</creatorcontrib><creatorcontrib>Takei, Yo-ichi</creatorcontrib><creatorcontrib>Ohara, Shinji</creatorcontrib><creatorcontrib>Watanabe, Nobuaki</creatorcontrib><creatorcontrib>Nakazawa, Kou</creatorcontrib><creatorcontrib>Oyanagi, Kiyomitsu</creatorcontrib><creatorcontrib>Kitano, Kiyoshi</creatorcontrib><title>Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection</title><title>Journal of Clinical and Experimental Hematopathology</title><addtitle>J Clin Exp Hematopathol</addtitle><description>We report here a case of a 37-year-old man with human immunodeficiency virus (HIV) infection followed by JC virus (JCV) infection and primary central nervous system lymphoma (PCNSL). The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. He had progression of nervous symptoms and was diagnosed with progressive multifocal leukoencephalopathy (PML) clinically at the age of 36, when his CD4-positive lymphocyte counts ranged between 350 and 450/μl. Oral mefloquine, intravenous methylprednisolone pulse therapy, and intravenous immunoglobulin were not effective for the PML, and the patient entered a vegetative state. Brain biopsy revealed JCV infection without pathological findings of PML. Eight months after the clinical diagnosis of PML, he developed respiratory failure and brain magnetic resonance imaging revealed a mass lesion in the brain stem. The patient died 19 months after the diagnosis of PML. Autopsy findings were compatible with PCNSL. EBV-encoded small RNA-1-positive cells were not detected. We present a case of JCV-positive PCNSL with HIV infection complicated with clinical PML.</description><subject>acquired immunodeficiency syndrome</subject><subject>Adult</subject><subject>Central Nervous System Diseases - pathology</subject><subject>Central Nervous System Diseases - virology</subject><subject>HIV infection</subject><subject>HIV Infections - pathology</subject><subject>HIV Infections - virology</subject><subject>Humans</subject><subject>JC Virus - isolation & purification</subject><subject>Leukoencephalopathy, Progressive Multifocal - pathology</subject><subject>Leukoencephalopathy, Progressive Multifocal - virology</subject><subject>Lymphoma - pathology</subject><subject>Lymphoma - virology</subject><subject>Male</subject><subject>primary central nervous system lymphoma</subject><subject>progressive multifocal leukoencephalopathy</subject><issn>1346-4280</issn><issn>1880-9952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1vGjEQhq0qVSG0t54j_4As9efanCJEPiBCbaUmva6MPS6L1rvINlTk12dbCDnNjOaZV5oHoa-UjPmkJN82qYl5LMWYUfoBDanWpJhMJLvoey7KQjBNBugypQ0hopQl_4QGTEpCKWVD9HILe2i6bYA2487jn7EOJh7wrJ-jafB3iPtul_CvQ8oQ8PIQtusuGDxNqbO1yeDw3zqv8XwXTIsXIezazoGvbQ2tPeDfdeyPTevw4-w0LFoPNtdd-xl99KZJ8OVUR-j5_u5pNi-WPx4Ws-mysFyxXHBODFdaO5BGKL5yTntFvfZOWdBWeKm45FJS4QxRwmrPnFZWsAlRZcmAj9D1MdfGLqUIvtoen6woqf4prP4rrKSoeoU9fnXEt7tVAHeG35z1wM0R2KRs_sAZMDHXtoH3NH6KPG_s2sQKWv4KGYeGxQ</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Kawakami, Toru</creator><creator>Sakai, Kaoko</creator><creator>Mimura, Yuto</creator><creator>Senoo, Yasushi</creator><creator>Hirabayashi, Yukio</creator><creator>Nakazawa, Hideyuki</creator><creator>Koshihara, Hiroshi</creator><creator>Oguchi, Kenya</creator><creator>Takei, Yo-ichi</creator><creator>Ohara, Shinji</creator><creator>Watanabe, Nobuaki</creator><creator>Nakazawa, Kou</creator><creator>Oyanagi, Kiyomitsu</creator><creator>Kitano, Kiyoshi</creator><general>The Japanese Society for Lymphoreticular Tissue Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2014</creationdate><title>Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection</title><author>Kawakami, Toru ; Sakai, Kaoko ; Mimura, Yuto ; Senoo, Yasushi ; Hirabayashi, Yukio ; Nakazawa, Hideyuki ; Koshihara, Hiroshi ; Oguchi, Kenya ; Takei, Yo-ichi ; Ohara, Shinji ; Watanabe, Nobuaki ; Nakazawa, Kou ; Oyanagi, Kiyomitsu ; Kitano, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-330a3788de5a473bdd8f71f8fd7ce8c4f573535514da074c8f2d87c42907662e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>acquired immunodeficiency syndrome</topic><topic>Adult</topic><topic>Central Nervous System Diseases - pathology</topic><topic>Central Nervous System Diseases - virology</topic><topic>HIV infection</topic><topic>HIV Infections - pathology</topic><topic>HIV Infections - virology</topic><topic>Humans</topic><topic>JC Virus - isolation & purification</topic><topic>Leukoencephalopathy, Progressive Multifocal - pathology</topic><topic>Leukoencephalopathy, Progressive Multifocal - virology</topic><topic>Lymphoma - pathology</topic><topic>Lymphoma - virology</topic><topic>Male</topic><topic>primary central nervous system lymphoma</topic><topic>progressive multifocal leukoencephalopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, Toru</creatorcontrib><creatorcontrib>Sakai, Kaoko</creatorcontrib><creatorcontrib>Mimura, Yuto</creatorcontrib><creatorcontrib>Senoo, Yasushi</creatorcontrib><creatorcontrib>Hirabayashi, Yukio</creatorcontrib><creatorcontrib>Nakazawa, Hideyuki</creatorcontrib><creatorcontrib>Koshihara, Hiroshi</creatorcontrib><creatorcontrib>Oguchi, Kenya</creatorcontrib><creatorcontrib>Takei, Yo-ichi</creatorcontrib><creatorcontrib>Ohara, Shinji</creatorcontrib><creatorcontrib>Watanabe, Nobuaki</creatorcontrib><creatorcontrib>Nakazawa, Kou</creatorcontrib><creatorcontrib>Oyanagi, Kiyomitsu</creatorcontrib><creatorcontrib>Kitano, Kiyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Clinical and Experimental Hematopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, Toru</au><au>Sakai, Kaoko</au><au>Mimura, Yuto</au><au>Senoo, Yasushi</au><au>Hirabayashi, Yukio</au><au>Nakazawa, Hideyuki</au><au>Koshihara, Hiroshi</au><au>Oguchi, Kenya</au><au>Takei, Yo-ichi</au><au>Ohara, Shinji</au><au>Watanabe, Nobuaki</au><au>Nakazawa, Kou</au><au>Oyanagi, Kiyomitsu</au><au>Kitano, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection</atitle><jtitle>Journal of Clinical and Experimental Hematopathology</jtitle><addtitle>J Clin Exp Hematopathol</addtitle><date>2014</date><risdate>2014</risdate><volume>54</volume><issue>3</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>1346-4280</issn><eissn>1880-9952</eissn><abstract>We report here a case of a 37-year-old man with human immunodeficiency virus (HIV) infection followed by JC virus (JCV) infection and primary central nervous system lymphoma (PCNSL). The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. He had progression of nervous symptoms and was diagnosed with progressive multifocal leukoencephalopathy (PML) clinically at the age of 36, when his CD4-positive lymphocyte counts ranged between 350 and 450/μl. Oral mefloquine, intravenous methylprednisolone pulse therapy, and intravenous immunoglobulin were not effective for the PML, and the patient entered a vegetative state. Brain biopsy revealed JCV infection without pathological findings of PML. Eight months after the clinical diagnosis of PML, he developed respiratory failure and brain magnetic resonance imaging revealed a mass lesion in the brain stem. The patient died 19 months after the diagnosis of PML. Autopsy findings were compatible with PCNSL. EBV-encoded small RNA-1-positive cells were not detected. 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| subjects | acquired immunodeficiency syndrome Adult Central Nervous System Diseases - pathology Central Nervous System Diseases - virology HIV infection HIV Infections - pathology HIV Infections - virology Humans JC Virus - isolation & purification Leukoencephalopathy, Progressive Multifocal - pathology Leukoencephalopathy, Progressive Multifocal - virology Lymphoma - pathology Lymphoma - virology Male primary central nervous system lymphoma progressive multifocal leukoencephalopathy |
| title | Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection |
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