CD20-Positive and CD4/CD8-Double-Negative Peripheral T-Cell Lymphoma of Spleen Complicated with Severe Disseminated Intravascular Coagulation and Enteropathy
A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3+, CD4-, CD8-, T-cell receptor (TCR)αβ+, and TCRγδ-. After splenectomy,...
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| Veröffentlicht in: | Journal of Clinical and Experimental Hematopathology 2012, Vol.52(2), pp.133-136 |
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| container_title | Journal of Clinical and Experimental Hematopathology |
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| creator | Ichikawa, Satoshi Hatta, Shunsuke Saito, Yo Kimura, Jun Onishi, Keisuke Matsuda, Mikio Ichinohasama, Ryo Harigae, Hideo |
| description | A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3+, CD4-, CD8-, T-cell receptor (TCR)αβ+, and TCRγδ-. After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20+ PTCL-NOS. Although it is a rare disease entity, CD20+ T-cell lymphoma can demonstrate aggressive clinical behavior. [J Clin Exp Hematopathol 52(2) : 133-136, 2012] |
| doi_str_mv | 10.3960/jslrt.52.133 |
| format | Article |
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Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3+, CD4-, CD8-, T-cell receptor (TCR)αβ+, and TCRγδ-. After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20+ PTCL-NOS. Although it is a rare disease entity, CD20+ T-cell lymphoma can demonstrate aggressive clinical behavior. 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Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3+, CD4-, CD8-, T-cell receptor (TCR)αβ+, and TCRγδ-. After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20+ PTCL-NOS. Although it is a rare disease entity, CD20+ T-cell lymphoma can demonstrate aggressive clinical behavior. [J Clin Exp Hematopathol 52(2) : 133-136, 2012]</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Antigens, CD20 - genetics</subject><subject>CD20-positive T-cell lymphoma</subject><subject>CD4 Antigens - genetics</subject><subject>CD4/CD8-double-negative PTCL</subject><subject>CD8 Antigens - genetics</subject><subject>disseminated intravascular coagulation</subject><subject>Disseminated Intravascular Coagulation - complications</subject><subject>Disseminated Intravascular Coagulation - immunology</subject><subject>Disseminated Intravascular Coagulation - pathology</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Intestinal Diseases - complications</subject><subject>Intestinal Diseases - immunology</subject><subject>Intestinal Diseases - pathology</subject><subject>Lymphoma, T-Cell, Peripheral - complications</subject><subject>Lymphoma, T-Cell, Peripheral - immunology</subject><subject>Lymphoma, T-Cell, Peripheral - pathology</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Spleen - immunology</subject><subject>Spleen - pathology</subject><subject>Spleen - surgery</subject><subject>Splenectomy</subject><subject>Splenomegaly - complications</subject><subject>Splenomegaly - immunology</subject><subject>Splenomegaly - pathology</subject><subject>Splenomegaly - surgery</subject><issn>1346-4280</issn><issn>1880-9952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtuEzEQhi0EoqVwxzXyA-DUx83mCqHdApUiqNRyvZp4x1lH3oNsJygPw7uyJCVczUj_N_9IHyHvBV-oVcFvdynEvDByIZR6Qa5FWXK2Whn5ct6VLpiWJb8ib1Laca4LU6jX5EoqrpaF4tfkd1VLzh7G5LM_IIWhpVWtb6u6ZPW43wRk33ELp-wBo586jBDoE6swBLo-9lM39kBHRx-ngDjQauyn4C1kbOkvnzv6iAeMSGufEvZ-OAX3Q45wgGT3AeJ8Att5yX4cTv_vhoxxnCB3x7fklYOQ8N3zvCE_v9w9Vd_Y-sfX--rzmlmtZWaFFaUU2ILS1ugCAQ06t3SlLZWUK2MFmo3TbWlQuKUyyqJuhW6NM8A1V-qGfDz32jimFNE1U_Q9xGMjePPXcnOy3BjZzJZn_MMZn_abHtsL_E_rDHw6A7uUYYsXAGL2NuD_NvlceUlsB7HBQf0BaX-Sxg</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Ichikawa, Satoshi</creator><creator>Hatta, Shunsuke</creator><creator>Saito, Yo</creator><creator>Kimura, Jun</creator><creator>Onishi, Keisuke</creator><creator>Matsuda, Mikio</creator><creator>Ichinohasama, Ryo</creator><creator>Harigae, Hideo</creator><general>The Japanese Society for Lymphoreticular Tissue Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2012</creationdate><title>CD20-Positive and CD4/CD8-Double-Negative Peripheral T-Cell Lymphoma of Spleen Complicated with Severe Disseminated Intravascular Coagulation and Enteropathy</title><author>Ichikawa, Satoshi ; Hatta, Shunsuke ; Saito, Yo ; Kimura, Jun ; Onishi, Keisuke ; Matsuda, Mikio ; Ichinohasama, Ryo ; Harigae, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-6c1821eda34c546eae5eff7f8c832295c1e5bf4d85e1f7353ce4d14d5f5a04033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Antigens, CD20 - genetics</topic><topic>CD20-positive T-cell lymphoma</topic><topic>CD4 Antigens - genetics</topic><topic>CD4/CD8-double-negative PTCL</topic><topic>CD8 Antigens - genetics</topic><topic>disseminated intravascular coagulation</topic><topic>Disseminated Intravascular Coagulation - complications</topic><topic>Disseminated Intravascular Coagulation - immunology</topic><topic>Disseminated Intravascular Coagulation - pathology</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Intestinal Diseases - complications</topic><topic>Intestinal Diseases - immunology</topic><topic>Intestinal Diseases - pathology</topic><topic>Lymphoma, T-Cell, Peripheral - complications</topic><topic>Lymphoma, T-Cell, Peripheral - immunology</topic><topic>Lymphoma, T-Cell, Peripheral - pathology</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Spleen - immunology</topic><topic>Spleen - pathology</topic><topic>Spleen - surgery</topic><topic>Splenectomy</topic><topic>Splenomegaly - complications</topic><topic>Splenomegaly - immunology</topic><topic>Splenomegaly - pathology</topic><topic>Splenomegaly - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichikawa, Satoshi</creatorcontrib><creatorcontrib>Hatta, Shunsuke</creatorcontrib><creatorcontrib>Saito, Yo</creatorcontrib><creatorcontrib>Kimura, Jun</creatorcontrib><creatorcontrib>Onishi, Keisuke</creatorcontrib><creatorcontrib>Matsuda, Mikio</creatorcontrib><creatorcontrib>Ichinohasama, Ryo</creatorcontrib><creatorcontrib>Harigae, Hideo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Clinical and Experimental Hematopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichikawa, Satoshi</au><au>Hatta, Shunsuke</au><au>Saito, Yo</au><au>Kimura, Jun</au><au>Onishi, Keisuke</au><au>Matsuda, Mikio</au><au>Ichinohasama, Ryo</au><au>Harigae, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD20-Positive and CD4/CD8-Double-Negative Peripheral T-Cell Lymphoma of Spleen Complicated with Severe Disseminated Intravascular Coagulation and Enteropathy</atitle><jtitle>Journal of Clinical and Experimental Hematopathology</jtitle><addtitle>J Clin Exp Hematopathol</addtitle><date>2012</date><risdate>2012</risdate><volume>52</volume><issue>2</issue><spage>133</spage><epage>136</epage><pages>133-136</pages><issn>1346-4280</issn><eissn>1880-9952</eissn><abstract>A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3+, CD4-, CD8-, T-cell receptor (TCR)αβ+, and TCRγδ-. After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20+ PTCL-NOS. Although it is a rare disease entity, CD20+ T-cell lymphoma can demonstrate aggressive clinical behavior. [J Clin Exp Hematopathol 52(2) : 133-136, 2012]</abstract><cop>Japan</cop><pub>The Japanese Society for Lymphoreticular Tissue Research</pub><pmid>23037630</pmid><doi>10.3960/jslrt.52.133</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Aged Antigens, CD20 - genetics CD20-positive T-cell lymphoma CD4 Antigens - genetics CD4/CD8-double-negative PTCL CD8 Antigens - genetics disseminated intravascular coagulation Disseminated Intravascular Coagulation - complications Disseminated Intravascular Coagulation - immunology Disseminated Intravascular Coagulation - pathology Fatal Outcome Female Gene Expression Humans Intestinal Diseases - complications Intestinal Diseases - immunology Intestinal Diseases - pathology Lymphoma, T-Cell, Peripheral - complications Lymphoma, T-Cell, Peripheral - immunology Lymphoma, T-Cell, Peripheral - pathology Receptors, Antigen, T-Cell - genetics Spleen - immunology Spleen - pathology Spleen - surgery Splenectomy Splenomegaly - complications Splenomegaly - immunology Splenomegaly - pathology Splenomegaly - surgery |
| title | CD20-Positive and CD4/CD8-Double-Negative Peripheral T-Cell Lymphoma of Spleen Complicated with Severe Disseminated Intravascular Coagulation and Enteropathy |
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