Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease
Data from recent meta-analyses question an association between dietary intake of saturated fatty acids (SFAs) and risk of cardiovascular disease (CVD). Moreover, the prognostic effect of dietary SFA in patients with established CVD treated with modern conventional medication has not been extensively...
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| Veröffentlicht in: | The Journal of nutrition 2015-02, Vol.145 (2), p.299-305 |
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| creator | Puaschitz, Nathalie Genevieve Strand, Elin Norekvål, Tone Merete Dierkes, Jutta Dahl, Lisbeth Svingen, Gard Frodahl Tveitevåg Assmus, Jörg Schartum-Hansen, Hall Øyen, Jannike Pedersen, Eva Kristine Ringdal Drevon, Christian Andrè Tell, Grethe Seppola Nygård, Ottar |
| description | Data from recent meta-analyses question an association between dietary intake of saturated fatty acids (SFAs) and risk of cardiovascular disease (CVD). Moreover, the prognostic effect of dietary SFA in patients with established CVD treated with modern conventional medication has not been extensively studied.
We investigated the associations between self-reported dietary SFA intake and risk of subsequent coronary events and mortality in patients with coronary artery disease (CAD).
This study included patients who participated in the Western Norway B-Vitamin Intervention Trial and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography. Quartiles of estimated daily intakes of SFA were related to risk of a primary composite endpoint of coronary events (unstable angina pectoris, nonfatal acute myocardial infarction, and coronary death) and separate secondary endpoints (total acute myocardial infarction, fatal coronary events, and all-cause death) with use of Cox-regression analyses.
This study included 2412 patients (81% men, mean age: 61.7 y). After a median follow-up of 4.8 y, a total of 292 (12%) patients experienced at least one major coronary event during follow-up. High intake of SFAs was associated with a number of risk factors at baseline. However, there were no significant associations between SFA intake and risk of coronary events [age- and sex-adjusted HR (95% CI) was 0.85 (0.61, 1.18) for the upper vs. lower SFA quartile] or any secondary endpoint. Estimates were not appreciably changed after multivariate adjustments.
There was no association between dietary intake of SFAs and incident coronary events or mortality in patients with established CAD. |
| doi_str_mv | 10.3945/jn.114.203505 |
| format | Article |
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We investigated the associations between self-reported dietary SFA intake and risk of subsequent coronary events and mortality in patients with coronary artery disease (CAD).
This study included patients who participated in the Western Norway B-Vitamin Intervention Trial and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography. Quartiles of estimated daily intakes of SFA were related to risk of a primary composite endpoint of coronary events (unstable angina pectoris, nonfatal acute myocardial infarction, and coronary death) and separate secondary endpoints (total acute myocardial infarction, fatal coronary events, and all-cause death) with use of Cox-regression analyses.
This study included 2412 patients (81% men, mean age: 61.7 y). After a median follow-up of 4.8 y, a total of 292 (12%) patients experienced at least one major coronary event during follow-up. High intake of SFAs was associated with a number of risk factors at baseline. However, there were no significant associations between SFA intake and risk of coronary events [age- and sex-adjusted HR (95% CI) was 0.85 (0.61, 1.18) for the upper vs. lower SFA quartile] or any secondary endpoint. Estimates were not appreciably changed after multivariate adjustments.
There was no association between dietary intake of SFAs and incident coronary events or mortality in patients with established CAD.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.3945/jn.114.203505</identifier><identifier>PMID: 25644351</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Disease ; Aged ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - mortality ; Diet ; Dietary Fats - adverse effects ; Endpoint Determination ; Fatty Acids - adverse effects ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Myocardial Infarction - epidemiology ; Myocardial Infarction - mortality ; Norway - epidemiology ; Proportional Hazards Models ; Risk Factors ; Surveys and Questionnaires</subject><ispartof>The Journal of nutrition, 2015-02, Vol.145 (2), p.299-305</ispartof><rights>2015 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-fe0949eb6c0eccf210b4ea3e033728efb549f2d98a9e6530dfec175cd64bea5b3</citedby><cites>FETCH-LOGICAL-c332t-fe0949eb6c0eccf210b4ea3e033728efb549f2d98a9e6530dfec175cd64bea5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25644351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puaschitz, Nathalie Genevieve</creatorcontrib><creatorcontrib>Strand, Elin</creatorcontrib><creatorcontrib>Norekvål, Tone Merete</creatorcontrib><creatorcontrib>Dierkes, Jutta</creatorcontrib><creatorcontrib>Dahl, Lisbeth</creatorcontrib><creatorcontrib>Svingen, Gard Frodahl Tveitevåg</creatorcontrib><creatorcontrib>Assmus, Jörg</creatorcontrib><creatorcontrib>Schartum-Hansen, Hall</creatorcontrib><creatorcontrib>Øyen, Jannike</creatorcontrib><creatorcontrib>Pedersen, Eva Kristine Ringdal</creatorcontrib><creatorcontrib>Drevon, Christian Andrè</creatorcontrib><creatorcontrib>Tell, Grethe Seppola</creatorcontrib><creatorcontrib>Nygård, Ottar</creatorcontrib><title>Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Data from recent meta-analyses question an association between dietary intake of saturated fatty acids (SFAs) and risk of cardiovascular disease (CVD). Moreover, the prognostic effect of dietary SFA in patients with established CVD treated with modern conventional medication has not been extensively studied.
We investigated the associations between self-reported dietary SFA intake and risk of subsequent coronary events and mortality in patients with coronary artery disease (CAD).
This study included patients who participated in the Western Norway B-Vitamin Intervention Trial and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography. Quartiles of estimated daily intakes of SFA were related to risk of a primary composite endpoint of coronary events (unstable angina pectoris, nonfatal acute myocardial infarction, and coronary death) and separate secondary endpoints (total acute myocardial infarction, fatal coronary events, and all-cause death) with use of Cox-regression analyses.
This study included 2412 patients (81% men, mean age: 61.7 y). After a median follow-up of 4.8 y, a total of 292 (12%) patients experienced at least one major coronary event during follow-up. High intake of SFAs was associated with a number of risk factors at baseline. However, there were no significant associations between SFA intake and risk of coronary events [age- and sex-adjusted HR (95% CI) was 0.85 (0.61, 1.18) for the upper vs. lower SFA quartile] or any secondary endpoint. Estimates were not appreciably changed after multivariate adjustments.
There was no association between dietary intake of SFAs and incident coronary events or mortality in patients with established CAD.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - mortality</subject><subject>Diet</subject><subject>Dietary Fats - adverse effects</subject><subject>Endpoint Determination</subject><subject>Fatty Acids - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - mortality</subject><subject>Norway - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqWwZIv8AynjV9osUXlKldjAOnKcseo-4srjgvgLPpm0BVYjzZx7NTqMXQsYq0qb22U3FkKPJSgD5oQNhdGiKAXAKRsCSFkoUZYDdkG0BAChq-k5G0hTaq2MGLLv-4DZpi8eumxXyKPnZPMu2Ywt9zbzQLyLmVui6MJh-xnygqdAqz3sYordPo8f2GXiMfFNTNmuQ9538q3N4XA4pJCybdaBFn3Nf9KmjP1oA6ElvGRn3q4Jr37niL0_PrzNnov569PL7G5eOKVkLjxCpStsSgfonJcCGo1WISg1kVP0jdGVl201tRWWRkHr0YmJcW2pG7SmUSNWHHtdikQJfb1NYdP_Uwuo92brZVf3Zuuj2Z6_OfLbXbPB9p_-U6l-AICnePA</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Puaschitz, Nathalie Genevieve</creator><creator>Strand, Elin</creator><creator>Norekvål, Tone Merete</creator><creator>Dierkes, Jutta</creator><creator>Dahl, Lisbeth</creator><creator>Svingen, Gard Frodahl Tveitevåg</creator><creator>Assmus, Jörg</creator><creator>Schartum-Hansen, Hall</creator><creator>Øyen, Jannike</creator><creator>Pedersen, Eva Kristine Ringdal</creator><creator>Drevon, Christian Andrè</creator><creator>Tell, Grethe Seppola</creator><creator>Nygård, Ottar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150201</creationdate><title>Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease</title><author>Puaschitz, Nathalie Genevieve ; 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Moreover, the prognostic effect of dietary SFA in patients with established CVD treated with modern conventional medication has not been extensively studied.
We investigated the associations between self-reported dietary SFA intake and risk of subsequent coronary events and mortality in patients with coronary artery disease (CAD).
This study included patients who participated in the Western Norway B-Vitamin Intervention Trial and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography. Quartiles of estimated daily intakes of SFA were related to risk of a primary composite endpoint of coronary events (unstable angina pectoris, nonfatal acute myocardial infarction, and coronary death) and separate secondary endpoints (total acute myocardial infarction, fatal coronary events, and all-cause death) with use of Cox-regression analyses.
This study included 2412 patients (81% men, mean age: 61.7 y). After a median follow-up of 4.8 y, a total of 292 (12%) patients experienced at least one major coronary event during follow-up. High intake of SFAs was associated with a number of risk factors at baseline. However, there were no significant associations between SFA intake and risk of coronary events [age- and sex-adjusted HR (95% CI) was 0.85 (0.61, 1.18) for the upper vs. lower SFA quartile] or any secondary endpoint. Estimates were not appreciably changed after multivariate adjustments.
There was no association between dietary intake of SFAs and incident coronary events or mortality in patients with established CAD.</abstract><cop>United States</cop><pmid>25644351</pmid><doi>10.3945/jn.114.203505</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 2015-02, Vol.145 (2), p.299-305 |
| issn | 0022-3166 1541-6100 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acute Disease Aged Coronary Artery Disease - epidemiology Coronary Artery Disease - mortality Diet Dietary Fats - adverse effects Endpoint Determination Fatty Acids - adverse effects Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - mortality Norway - epidemiology Proportional Hazards Models Risk Factors Surveys and Questionnaires |
| title | Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease |
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