Phytosterols Reduce Cholesterol Absorption by Inhibition of 27-Hydroxycholesterol Generation, Liver X Receptor α Activation, and Expression of the Basolateral Sterol Exporter ATP-Binding Cassette A1 in Caco-2 Enterocytes

Phytosterol-enriched foods are increasingly marketed to lower cholesterol levels and atherosclerosis in the general population. Phytosterols reduce cholesterol absorption, but the molecular mechanism is controversial. We therefore investigated the phytosterol effects on cholesterol metabolism in hum...

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Veröffentlicht in:	The Journal of nutrition 2012-06, Vol.142 (6), p.981-989
Hauptverfasser:	BRAUNER, Reinhard, JOHANNES, Christian, PLOESSL, Florian, BRACHER, Franz, LORENZ, Reinhard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption - drug effects ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Caco-2 Cells Cholesterol - pharmacokinetics Enterocytes - drug effects Enterocytes - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Humans Hydroxycholesterols - metabolism Liver X Receptors Macrophages - drug effects Macrophages - metabolism Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism Phytosterols - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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