INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS

INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS

Sera from some multiple blood or platelet transfused patients inhibited the proliferation of alloreactive T cell clones which were stimulated and proliferated with the stimuli of allo major histocompatibility antigens (allo-MHC). The serum factors which were responsible for the inhibition appeared t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the Japan Society of Blood Transfusion 1992/06/15, Vol.38(3), pp.385-391
Hauptverfasser: Nishimura, Motoko, Sakai, Kumiko, Akaza, Tatsuya, Mitomi, Yoshitada, Nieda, Mie, Minami, Mutsuhiko, Juji, Takeo
Format: Artikel
Sprache:jpn
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 391
container_issue 3
container_start_page 385
container_title Journal of the Japan Society of Blood Transfusion
container_volume 38
creator Nishimura, Motoko
Sakai, Kumiko
Akaza, Tatsuya
Mitomi, Yoshitada
Nieda, Mie
Minami, Mutsuhiko
Juji, Takeo
description Sera from some multiple blood or platelet transfused patients inhibited the proliferation of alloreactive T cell clones which were stimulated and proliferated with the stimuli of allo major histocompatibility antigens (allo-MHC). The serum factors which were responsible for the inhibition appeared to bind to T cell clones, but not to stimulator cells. Further analysis revealed that one factor was included in immunoglobulin G fraction of the sera. From the competitive experiment with various monoclonal antibodies to membrane antigens of T cell clones, it was appeared that some sera contained antibody to T cell receptor (TCR) of some T cell clones. With the view of clone specific binding of anti-TCR antibody, it was proved that the antibody was anti-idiotypic antibody.
doi_str_mv 10.3925/jjtc1958.38.385
format Article
fullrecord <record><control><sourceid>jstage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3925_jjtc1958_38_385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>article_jjtc1958_38_3_38_3_385_article_char_en</sourcerecordid><originalsourceid>FETCH-LOGICAL-c158n-ec8fbedffe931330244559d0587ec4b86a9d6a18f12e0d295dfa5cb9b87c41ae3</originalsourceid><addsrcrecordid>eNpVkFFLwzAUhYMoOHTPvuYPdEuapEsfuy51gawpbSb4VNI01Y05pZ0P_ns35gbC4V649zvn4QDwhNGExCGbbrcHh2PGJ-QkdgNGmHMScMLJLRghRqMAU8rvwXgYtgghzDGPGB2Bb5kv5VwaqXOoM1iUWslMlMnlkCilS5GkRr4IaGAqlIKp0rmo4PwVVkcSZqVewdVaGVkoAedK6wXUJSxUYoQSBpoyyatsXYkFLI65IjfVI7jr7G7w47_9ANaZMOkyUPpZpokKHGZ8H3jHu8a3XedjgglBIaWMxS1ifOYdbXhk4zaymHc49KgNY9Z2lrkmbvjMUWw9eQDTc67rP4eh91391W8-bP9TY1SfiqsvxdXkJHZ0LM6O7XCwb_7K2_6wcTv_n78Mdn27d9vXfk9-ARlicT4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS</title><source>J-STAGE</source><creator>Nishimura, Motoko ; Sakai, Kumiko ; Akaza, Tatsuya ; Mitomi, Yoshitada ; Nieda, Mie ; Minami, Mutsuhiko ; Juji, Takeo</creator><creatorcontrib>Nishimura, Motoko ; Sakai, Kumiko ; Akaza, Tatsuya ; Mitomi, Yoshitada ; Nieda, Mie ; Minami, Mutsuhiko ; Juji, Takeo</creatorcontrib><description>Sera from some multiple blood or platelet transfused patients inhibited the proliferation of alloreactive T cell clones which were stimulated and proliferated with the stimuli of allo major histocompatibility antigens (allo-MHC). The serum factors which were responsible for the inhibition appeared to bind to T cell clones, but not to stimulator cells. Further analysis revealed that one factor was included in immunoglobulin G fraction of the sera. From the competitive experiment with various monoclonal antibodies to membrane antigens of T cell clones, it was appeared that some sera contained antibody to T cell receptor (TCR) of some T cell clones. With the view of clone specific binding of anti-TCR antibody, it was proved that the antibody was anti-idiotypic antibody.</description><identifier>ISSN: 0546-1448</identifier><identifier>EISSN: 1883-8383</identifier><identifier>DOI: 10.3925/jjtc1958.38.385</identifier><language>jpn</language><publisher>The Japan Society of Transfusion Medicine and Cell Therapy</publisher><ispartof>Journal of the Japan Society of Blood Transfusion, 1992/06/15, Vol.38(3), pp.385-391</ispartof><rights>The Japan Society of Transfusion Medicine and Cell Therapy</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids></links><search><creatorcontrib>Nishimura, Motoko</creatorcontrib><creatorcontrib>Sakai, Kumiko</creatorcontrib><creatorcontrib>Akaza, Tatsuya</creatorcontrib><creatorcontrib>Mitomi, Yoshitada</creatorcontrib><creatorcontrib>Nieda, Mie</creatorcontrib><creatorcontrib>Minami, Mutsuhiko</creatorcontrib><creatorcontrib>Juji, Takeo</creatorcontrib><title>INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS</title><title>Journal of the Japan Society of Blood Transfusion</title><addtitle>J. j. t. m</addtitle><description>Sera from some multiple blood or platelet transfused patients inhibited the proliferation of alloreactive T cell clones which were stimulated and proliferated with the stimuli of allo major histocompatibility antigens (allo-MHC). The serum factors which were responsible for the inhibition appeared to bind to T cell clones, but not to stimulator cells. Further analysis revealed that one factor was included in immunoglobulin G fraction of the sera. From the competitive experiment with various monoclonal antibodies to membrane antigens of T cell clones, it was appeared that some sera contained antibody to T cell receptor (TCR) of some T cell clones. With the view of clone specific binding of anti-TCR antibody, it was proved that the antibody was anti-idiotypic antibody.</description><issn>0546-1448</issn><issn>1883-8383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNpVkFFLwzAUhYMoOHTPvuYPdEuapEsfuy51gawpbSb4VNI01Y05pZ0P_ns35gbC4V649zvn4QDwhNGExCGbbrcHh2PGJ-QkdgNGmHMScMLJLRghRqMAU8rvwXgYtgghzDGPGB2Bb5kv5VwaqXOoM1iUWslMlMnlkCilS5GkRr4IaGAqlIKp0rmo4PwVVkcSZqVewdVaGVkoAedK6wXUJSxUYoQSBpoyyatsXYkFLI65IjfVI7jr7G7w47_9ANaZMOkyUPpZpokKHGZ8H3jHu8a3XedjgglBIaWMxS1ifOYdbXhk4zaymHc49KgNY9Z2lrkmbvjMUWw9eQDTc67rP4eh91391W8-bP9TY1SfiqsvxdXkJHZ0LM6O7XCwb_7K2_6wcTv_n78Mdn27d9vXfk9-ARlicT4</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Nishimura, Motoko</creator><creator>Sakai, Kumiko</creator><creator>Akaza, Tatsuya</creator><creator>Mitomi, Yoshitada</creator><creator>Nieda, Mie</creator><creator>Minami, Mutsuhiko</creator><creator>Juji, Takeo</creator><general>The Japan Society of Transfusion Medicine and Cell Therapy</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1992</creationdate><title>INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS</title><author>Nishimura, Motoko ; Sakai, Kumiko ; Akaza, Tatsuya ; Mitomi, Yoshitada ; Nieda, Mie ; Minami, Mutsuhiko ; Juji, Takeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c158n-ec8fbedffe931330244559d0587ec4b86a9d6a18f12e0d295dfa5cb9b87c41ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1992</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Nishimura, Motoko</creatorcontrib><creatorcontrib>Sakai, Kumiko</creatorcontrib><creatorcontrib>Akaza, Tatsuya</creatorcontrib><creatorcontrib>Mitomi, Yoshitada</creatorcontrib><creatorcontrib>Nieda, Mie</creatorcontrib><creatorcontrib>Minami, Mutsuhiko</creatorcontrib><creatorcontrib>Juji, Takeo</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of the Japan Society of Blood Transfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishimura, Motoko</au><au>Sakai, Kumiko</au><au>Akaza, Tatsuya</au><au>Mitomi, Yoshitada</au><au>Nieda, Mie</au><au>Minami, Mutsuhiko</au><au>Juji, Takeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS</atitle><jtitle>Journal of the Japan Society of Blood Transfusion</jtitle><addtitle>J. j. t. m</addtitle><date>1992</date><risdate>1992</risdate><volume>38</volume><issue>3</issue><spage>385</spage><epage>391</epage><pages>385-391</pages><issn>0546-1448</issn><eissn>1883-8383</eissn><abstract>Sera from some multiple blood or platelet transfused patients inhibited the proliferation of alloreactive T cell clones which were stimulated and proliferated with the stimuli of allo major histocompatibility antigens (allo-MHC). The serum factors which were responsible for the inhibition appeared to bind to T cell clones, but not to stimulator cells. Further analysis revealed that one factor was included in immunoglobulin G fraction of the sera. From the competitive experiment with various monoclonal antibodies to membrane antigens of T cell clones, it was appeared that some sera contained antibody to T cell receptor (TCR) of some T cell clones. With the view of clone specific binding of anti-TCR antibody, it was proved that the antibody was anti-idiotypic antibody.</abstract><pub>The Japan Society of Transfusion Medicine and Cell Therapy</pub><doi>10.3925/jjtc1958.38.385</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0546-1448
ispartof Journal of the Japan Society of Blood Transfusion, 1992/06/15, Vol.38(3), pp.385-391
issn 0546-1448
1883-8383
language jpn
recordid cdi_crossref_primary_10_3925_jjtc1958_38_385
source J-STAGE
title INHIBITION OF PROLIFERATION OF ALLOREACTIVE T CELL CLONES BY SERA FROM MULTIPLE BLOOD OR PLATELET TRANSFUSED PATIENTS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A37%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=INHIBITION%20OF%20PROLIFERATION%20OF%20ALLOREACTIVE%20T%20CELL%20CLONES%20BY%20SERA%20FROM%20MULTIPLE%20BLOOD%20OR%20PLATELET%20TRANSFUSED%20PATIENTS&rft.jtitle=Journal%20of%20the%20Japan%20Society%20of%20Blood%20Transfusion&rft.au=Nishimura,%20Motoko&rft.date=1992&rft.volume=38&rft.issue=3&rft.spage=385&rft.epage=391&rft.pages=385-391&rft.issn=0546-1448&rft.eissn=1883-8383&rft_id=info:doi/10.3925/jjtc1958.38.385&rft_dat=%3Cjstage_cross%3Earticle_jjtc1958_38_3_38_3_385_article_char_en%3C/jstage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true