CHANGES OF HEMOSTATIC MOLECULAR MARKERS DURING DONOR PLATELETPHERESES USING CELL SEPARATORS

The changes of hemostatic molecular markers such as beta-thromboglobulin, platelet factor 4, fibrinopeptide A, soluble fibrin monomer complex, fibrinopeptide B beta 15-42, fibrin degradation product and fibrinogen are measured during donor plateltphereses using cell separators. They are most sensitive markers of platelet, coagulation system, and fibrinolysis. Plateletphereses were performed using Phenwall CS3000 in 13 cases and IBM2997 in 8 cases. Platelet and coagulation system were activated during plateletpheresis, although any side effect was not recognized. From the results we perform that processed volume of whole blood should be limited 2, 000ml, approximately half of ordinary apheresis, in cases of donors from the age of 45 to 54. In addition donors who are considered to have any risk factor for thrombosis also should be omitted for plateletpheresis.