What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model

What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model

This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (...

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Veröffentlicht in:TURKISH JOURNAL OF MEDICAL SCIENCES 2021-01, Vol.51 (5), p.2698-2704
Hauptverfasser: Demİrcİ, Adnan YalÇin, GÜvenÇ, Yahya, Özeren, Ersİn, Akyol, Çetİn, Bayram, Pinar, Bİllur, Denİz, Aydin, Sevİm, SeÇkİn, Hakan, YİĞİtkanli, Kazim
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creator Demİrcİ, Adnan YalÇin
GÜvenÇ, Yahya
Özeren, Ersİn
Akyol, Çetİn
Bayram, Pinar
Bİllur, Denİz
Aydin, Sevİm
SeÇkİn, Hakan
YİĞİtkanli, Kazim
description This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n=6), SAH group (n=6), and SAH+BVZ group (n=6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ 2 days after the SAH. Basilar artery diameters were measured with magnetic resonance angiography (MRA) 72 hours after the SAH in all groups. After 72 hours the animals? whole brains, including the upper cervical region, were obtained from all the animals after perfusion and fixation of the animal. The wall thickness, luminal area, and the apoptosis at the basilar arteries were evaluated in all groups. BVZ significantly prevented SAH induced vasospasm confirmed in-vivo with MRA imaging with additional suppression of apoptosis on basilar artery wall. VEGF inhibition with BVZ has shown to have a vasospasm and apoptosis attenuating effect on basilar artery in a SAH model.
doi_str_mv 10.3906/sag-2001-230
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title What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model
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