Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats
The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period. In order to determine the behavioral and neurochemical effects of MSG, the ex...
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| Veröffentlicht in: | Turkish journal of medical sciences 2017-01, Vol.47 (3), p.1002-1011 |
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| container_title | Turkish journal of medical sciences |
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| creator | Çetin Kardeşler, Ayşen Başkale, Eyüp |
| description | The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period.
In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.
Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values.
MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats. |
| doi_str_mv | 10.3906/sag-1511-92 |
| format | Article |
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In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.
Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values.
MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats.</description><identifier>ISSN: 1300-0144</identifier><identifier>EISSN: 1303-6165</identifier><identifier>DOI: 10.3906/sag-1511-92</identifier><identifier>PMID: 28618758</identifier><language>eng</language><publisher>Turkey</publisher><subject>Animals ; Animals, Newborn ; Behavior, Animal - drug effects ; Brain Chemistry - drug effects ; Catecholamines - analysis ; Dopamine - analysis ; gamma-Aminobutyric Acid - analysis ; Glutamic Acid - analysis ; Male ; Maze Learning - drug effects ; Rats ; Rats, Wistar ; Sodium Glutamate - pharmacology</subject><ispartof>Turkish journal of medical sciences, 2017-01, Vol.47 (3), p.1002-1011</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-ea2774cdfc898231497964aa3ac8cca48a43213143a14ab32907b9061f4b84083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28618758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çetin Kardeşler, Ayşen</creatorcontrib><creatorcontrib>Başkale, Eyüp</creatorcontrib><title>Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats</title><title>Turkish journal of medical sciences</title><addtitle>Turk J Med Sci</addtitle><description>The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period.
In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.
Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values.
MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Catecholamines - analysis</subject><subject>Dopamine - analysis</subject><subject>gamma-Aminobutyric Acid - analysis</subject><subject>Glutamic Acid - analysis</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium Glutamate - pharmacology</subject><issn>1300-0144</issn><issn>1303-6165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMoVqsr95K9RPOamWQpxUeh4EbXw51M0o50kpJkCv57U6uu7uHwceB-CN0wei80rR8SrAmrGCOan6ALJqggNaur059MCWVSztBlSp-UciErfY5mXNVMNZW6QN3S723KwxryEDwODueNxZ3dwH4IEbYYfI-9nWIwGzsOpjTWOWtyOrBj8CGFfphGvN5OGUbIFpcZb4OHXNgIOV2hMwfbZK9_7xx9PD-9L17J6u1luXhcEcO1yMQCbxppemeUVlwwqRtdSwABRhkDUoEUnJVeAJPQCa5p05X_mZOdklSJObo77poYUorWtbs4jBC_Wkbbg6m2mGoPplrNC317pHdTN9r-n_1TI74BpkBlVQ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Çetin Kardeşler, Ayşen</creator><creator>Başkale, Eyüp</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170101</creationdate><title>Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats</title><author>Çetin Kardeşler, Ayşen ; Başkale, Eyüp</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-ea2774cdfc898231497964aa3ac8cca48a43213143a14ab32907b9061f4b84083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain Chemistry - drug effects</topic><topic>Catecholamines - analysis</topic><topic>Dopamine - analysis</topic><topic>gamma-Aminobutyric Acid - analysis</topic><topic>Glutamic Acid - analysis</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium Glutamate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çetin Kardeşler, Ayşen</creatorcontrib><creatorcontrib>Başkale, Eyüp</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Turkish journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çetin Kardeşler, Ayşen</au><au>Başkale, Eyüp</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats</atitle><jtitle>Turkish journal of medical sciences</jtitle><addtitle>Turk J Med Sci</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>47</volume><issue>3</issue><spage>1002</spage><epage>1011</epage><pages>1002-1011</pages><issn>1300-0144</issn><eissn>1303-6165</eissn><abstract>The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period.
In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.
Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values.
MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats.</abstract><cop>Turkey</cop><pmid>28618758</pmid><doi>10.3906/sag-1511-92</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1300-0144 |
| ispartof | Turkish journal of medical sciences, 2017-01, Vol.47 (3), p.1002-1011 |
| issn | 1300-0144 1303-6165 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; TÜBİTAK Scientific Journals |
| subjects | Animals Animals, Newborn Behavior, Animal - drug effects Brain Chemistry - drug effects Catecholamines - analysis Dopamine - analysis gamma-Aminobutyric Acid - analysis Glutamic Acid - analysis Male Maze Learning - drug effects Rats Rats, Wistar Sodium Glutamate - pharmacology |
| title | Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats |
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