The impact of conventional or hypofractionated radiotherapy on voice quality and oncological outcome in patients with early glottic cancer

The hypothesis being tested in this study is that hypofractionated radiotherapy is well tolerated and not lower in terms of oncological outcome than conventional radiotherapy. Forty patients with histologically proven glottic cancer were included in the analysis. Twenty-two were treated by hypofract...

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Veröffentlicht in:Oncology reports 2010-11, Vol.24 (5), p.1383-1388
Hauptverfasser: DI NICOLA, L, GRAVINA, G. L, MARAMPON, F, BONFILI, P, BUONOPANE, S, DI STASO, M, FESTUCCIA, C, FRANZESE, P, TOMBOLINI, M, TOMBOLINI, V
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container_issue 5
container_start_page 1383
container_title Oncology reports
container_volume 24
creator DI NICOLA, L
GRAVINA, G. L
MARAMPON, F
BONFILI, P
BUONOPANE, S
DI STASO, M
FESTUCCIA, C
FRANZESE, P
TOMBOLINI, M
TOMBOLINI, V
description The hypothesis being tested in this study is that hypofractionated radiotherapy is well tolerated and not lower in terms of oncological outcome than conventional radiotherapy. Forty patients with histologically proven glottic cancer were included in the analysis. Twenty-two were treated by hypofractionated radiotherapy (3D-HFRT) (25 fractions of 2.4 Gy delivered daily to a total dose of 60 Gy). This group was retrospectively compared to 18 subjects who met the same inclusion criteria and who were treated with conventional radiotherapy (3D-CRT) (33 fractions of 2 Gy delivered daily to a total dose of 66 Gy). One year after RT treatment in 10 patients (5 in the arm-1 and 5 in the arm-2) mild dysphonia persisted. The other patients achieved a complete recovery of the overall quality of voice with no significant difference documented between the two groups. At 3 years the local control rate was 100% for the patients treated with hypofractionated radiotherapy and 96% for the patients treated with conventional regimen. The statistical analysis did not show any significant difference in local control between the two groups (p=0.45). No significant acute and late toxicity was documented in both groups. Subjects with early glottic cancer seem to experience comparable levels of morbidity irrespective whether they were treated by hypofractionated or conventional conformal therapy without any worsening of the tumor local control. Thus, we provide clinical evidence to justify trends already emerging toward hypofractionated regimens in early glottic cancer.
doi_str_mv 10.3892/or_00000996
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L ; MARAMPON, F ; BONFILI, P ; BUONOPANE, S ; DI STASO, M ; FESTUCCIA, C ; FRANZESE, P ; TOMBOLINI, M ; TOMBOLINI, V</creator><creatorcontrib>DI NICOLA, L ; GRAVINA, G. L ; MARAMPON, F ; BONFILI, P ; BUONOPANE, S ; DI STASO, M ; FESTUCCIA, C ; FRANZESE, P ; TOMBOLINI, M ; TOMBOLINI, V</creatorcontrib><description>The hypothesis being tested in this study is that hypofractionated radiotherapy is well tolerated and not lower in terms of oncological outcome than conventional radiotherapy. Forty patients with histologically proven glottic cancer were included in the analysis. Twenty-two were treated by hypofractionated radiotherapy (3D-HFRT) (25 fractions of 2.4 Gy delivered daily to a total dose of 60 Gy). This group was retrospectively compared to 18 subjects who met the same inclusion criteria and who were treated with conventional radiotherapy (3D-CRT) (33 fractions of 2 Gy delivered daily to a total dose of 66 Gy). One year after RT treatment in 10 patients (5 in the arm-1 and 5 in the arm-2) mild dysphonia persisted. The other patients achieved a complete recovery of the overall quality of voice with no significant difference documented between the two groups. At 3 years the local control rate was 100% for the patients treated with hypofractionated radiotherapy and 96% for the patients treated with conventional regimen. The statistical analysis did not show any significant difference in local control between the two groups (p=0.45). No significant acute and late toxicity was documented in both groups. Subjects with early glottic cancer seem to experience comparable levels of morbidity irrespective whether they were treated by hypofractionated or conventional conformal therapy without any worsening of the tumor local control. 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Stomatology ; Radiotherapy, Adjuvant - adverse effects ; Radiotherapy, Adjuvant - methods ; Retrospective Studies ; Treatment Outcome ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Vocal Cords - physiopathology ; Vocal Cords - radiation effects ; Voice Quality - radiation effects</subject><ispartof>Oncology reports, 2010-11, Vol.24 (5), p.1383-1388</ispartof><rights>2015 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=23335683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20878134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DI NICOLA, L</creatorcontrib><creatorcontrib>GRAVINA, G. L</creatorcontrib><creatorcontrib>MARAMPON, F</creatorcontrib><creatorcontrib>BONFILI, P</creatorcontrib><creatorcontrib>BUONOPANE, S</creatorcontrib><creatorcontrib>DI STASO, M</creatorcontrib><creatorcontrib>FESTUCCIA, C</creatorcontrib><creatorcontrib>FRANZESE, P</creatorcontrib><creatorcontrib>TOMBOLINI, M</creatorcontrib><creatorcontrib>TOMBOLINI, V</creatorcontrib><title>The impact of conventional or hypofractionated radiotherapy on voice quality and oncological outcome in patients with early glottic cancer</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>The hypothesis being tested in this study is that hypofractionated radiotherapy is well tolerated and not lower in terms of oncological outcome than conventional radiotherapy. Forty patients with histologically proven glottic cancer were included in the analysis. Twenty-two were treated by hypofractionated radiotherapy (3D-HFRT) (25 fractions of 2.4 Gy delivered daily to a total dose of 60 Gy). 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Stomatology</subject><subject>Radiotherapy, Adjuvant - adverse effects</subject><subject>Radiotherapy, Adjuvant - methods</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Vocal Cords - physiopathology</subject><subject>Vocal Cords - radiation effects</subject><subject>Voice Quality - radiation effects</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMlOwzAQhi0EoqVw4o584YQCXlInPqKKTarEpQdukeOlMUrjYLtFeQWeGkctiy9jzXz6R_MBcInRLS05uXO-QuPjnB2BKS44zkhO8XH6I4IzSudvE3AWwjtCpECMn4IJQWVRYppPwdeq0dBueiEjdAZK1-10F63rRAudh83QO-PTcOxEraAXyrrYaC_6AboO7pyVGn5sRWvjAEWnUlO61q2tHBO2UbpNWtDBXkSbkgP8tLGBWvh2gOvWxWgllKKT2p-DEyPaoC8OdQZWjw-rxXO2fH16WdwvM5nOihk35VxQZIhGecE4rRU3hHLFDDaCUKY4rnNT1KXCRDGMcslFyXCha11KXNAZuNnHSu9C8NpUvbcb4YcKo2oUWv0TmuirPd1v641Wv-yPwQRcHwAR0slJVidt-ONo8s9KSr8BKJuBwA</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>DI NICOLA, L</creator><creator>GRAVINA, G. 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Stomatology</topic><topic>Radiotherapy, Adjuvant - adverse effects</topic><topic>Radiotherapy, Adjuvant - methods</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Vocal Cords - physiopathology</topic><topic>Vocal Cords - radiation effects</topic><topic>Voice Quality - radiation effects</topic><toplevel>online_resources</toplevel><creatorcontrib>DI NICOLA, L</creatorcontrib><creatorcontrib>GRAVINA, G. 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subjects Aged
Aged, 80 and over
Biological and medical sciences
Dose Fractionation, Radiation
Dysphonia - etiology
Female
Glottis - pathology
Glottis - radiation effects
Humans
Laryngeal Neoplasms - physiopathology
Laryngeal Neoplasms - radiotherapy
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Radiotherapy, Adjuvant - adverse effects
Radiotherapy, Adjuvant - methods
Retrospective Studies
Treatment Outcome
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Vocal Cords - physiopathology
Vocal Cords - radiation effects
Voice Quality - radiation effects
title The impact of conventional or hypofractionated radiotherapy on voice quality and oncological outcome in patients with early glottic cancer
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