Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue

Adiponectin is secreted by adipocytes and is a key hormone responsible for insulin sensitization. Recent studies have shown that plasma adiponectin is decreased in patients with breast, endometrial and gastric cancer. However, the effect of adiponectin on colorectal carcinogenesis is controversial....

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Veröffentlicht in:Oncology reports 2008-09, Vol.20 (3), p.479-483
Hauptverfasser: YONEDA, Kyoko, TOMIMOTO, Ayako, INAMORI, Masahiko, NAKAJIMA, Noriko, WADA, Koichiro, NAGASHIMA, Yoji, NAKAGAMA, Hitoshi, UOZAKI, Hiroshi, FUKAYAMA, Masashi, NAKAJIMA, Atsushi, ENDO, Hiroki, IIDA, Hiroshi, SUGIYAMA, Michiko, TAKAHASHI, Hirokazu, MAWATARI, Hironori, NOZAKI, Yuichi, FUJITA, Koji, YONEDA, Masato
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container_end_page 483
container_issue 3
container_start_page 479
container_title Oncology reports
container_volume 20
creator YONEDA, Kyoko
TOMIMOTO, Ayako
INAMORI, Masahiko
NAKAJIMA, Noriko
WADA, Koichiro
NAGASHIMA, Yoji
NAKAGAMA, Hitoshi
UOZAKI, Hiroshi
FUKAYAMA, Masashi
NAKAJIMA, Atsushi
ENDO, Hiroki
IIDA, Hiroshi
SUGIYAMA, Michiko
TAKAHASHI, Hirokazu
MAWATARI, Hironori
NOZAKI, Yuichi
FUJITA, Koji
YONEDA, Masato
description Adiponectin is secreted by adipocytes and is a key hormone responsible for insulin sensitization. Recent studies have shown that plasma adiponectin is decreased in patients with breast, endometrial and gastric cancer. However, the effect of adiponectin on colorectal carcinogenesis is controversial. It is now well known that the adiponectin receptor exists in two isoforms, adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). We examined the expression of the adiponectin receptors on normal colon mucosa and colon cancer tissues in a human study using real-time RT-PCR, Western blotting and immunohistochemical staining. Adiponectin receptors, AdipoR1/AdipoR2, were expressed in normal colon epithelial and colon cancer cells. Furthermore, laser microdissection was performed to confirm our results. These results suggest that adiponectin may exert some effects on normal colon epithelium or colon cancer cells directly through adiponectin receptors. Further studies are required to elucidate the function of the AdipoRs activated by adiponectin and the downstream mechanisms of AdipoRs in colon cancer cells.
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Recent studies have shown that plasma adiponectin is decreased in patients with breast, endometrial and gastric cancer. However, the effect of adiponectin on colorectal carcinogenesis is controversial. It is now well known that the adiponectin receptor exists in two isoforms, adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). We examined the expression of the adiponectin receptors on normal colon mucosa and colon cancer tissues in a human study using real-time RT-PCR, Western blotting and immunohistochemical staining. Adiponectin receptors, AdipoR1/AdipoR2, were expressed in normal colon epithelial and colon cancer cells. Furthermore, laser microdissection was performed to confirm our results. These results suggest that adiponectin may exert some effects on normal colon epithelium or colon cancer cells directly through adiponectin receptors. 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identifier ISSN: 1021-335X
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Biological and medical sciences
Blotting, Western
Colon - metabolism
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Intestinal Mucosa - metabolism
Male
Medical sciences
Middle Aged
Receptors, Adiponectin - genetics
Receptors, Adiponectin - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
title Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue
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