Mechanistic studies of cytotoxic activity of the mesoionic compound MIH 2.4Bl in MCF‑7 breast cancer cells

In the present study, the cytotoxic effects of a 1,3-thiazolium-5-thiolate derivative of a mesoionic compound, MIH 2.4Bl, were assessed in the MCF-7 breast cancer cell line. The cytotoxic effects of MIH 2.4Bl were determined using a crystal violet assay. Using a dose-response curve, the IC50 value o...

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Veröffentlicht in:	Oncology letters 2020-09, Vol.20 (3), p.2291-2301
Hauptverfasser:	de Mascena Costa, Luciana, Debnath, Dipti, Harmon, Ashlyn, de Sousa Araújo, Silvany, da Silva Souza, Helivaldo, de Athayde Filho, Petrônio, Wischral, Aurea, Adrião Gomes Filho, Manoel, Mathis, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Apoptosis Breast cancer Cell cycle Cytotoxicity Investigations Melanoma Mitochondria NMR Nuclear magnetic resonance Oncology Spectrum analysis
Online-Zugang:	Volltext
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