MicroRNA miR-125b is a prognostic marker in human colorectal cancer
MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investig...
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| Veröffentlicht in: | International journal of oncology 2011-05, Vol.38 (5), p.1437-1443 |
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| container_title | International journal of oncology |
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| creator | NISHIDA, Naohiro YOKOBORI, Takehiko MIMORI, Koshi SUDO, Tomoya TANAKA, Fumiaki SHIBATA, Kohei ISHII, Hideshi DOKI, Yuichiro KUWANO, Hiroyuki MORI, Masaki |
| description | MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 colorectal cancer cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced tumor size and tumor invasion compared to the low miR-125b expression group (P |
| doi_str_mv | 10.3892/ijo.2011.969 |
| format | Article |
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Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 colorectal cancer cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced tumor size and tumor invasion compared to the low miR-125b expression group (P<0.05). In addition, the high miR-125b expression group had a significantly poorer prognosis compared to the low expression group (P<0.05). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. Our analysis of miR-125b focused on the miR-125b/p53 pathway. In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells. These data show that miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2011.969</identifier><identifier>PMID: 21399871</identifier><language>eng</language><publisher>Athens: Editorial Academy of the International Journal of Oncology</publisher><subject>Aged ; Biological and medical sciences ; Cell Line, Tumor ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Cyclin-Dependent Kinase Inhibitor p21 - genetics ; Disease Progression ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genes, p53 ; Humans ; Male ; Medical sciences ; MicroRNAs - genetics ; MicroRNAs - physiology ; Middle Aged ; Prognosis ; RNA, Messenger - analysis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>International journal of oncology, 2011-05, Vol.38 (5), p.1437-1443</ispartof><rights>2015 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-5c1a351a0aa4cbd0e0b28616d1e9cc3478ce34f42e5f152a0d46978246b1d6863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24066262$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21399871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NISHIDA, Naohiro</creatorcontrib><creatorcontrib>YOKOBORI, Takehiko</creatorcontrib><creatorcontrib>MIMORI, Koshi</creatorcontrib><creatorcontrib>SUDO, Tomoya</creatorcontrib><creatorcontrib>TANAKA, Fumiaki</creatorcontrib><creatorcontrib>SHIBATA, Kohei</creatorcontrib><creatorcontrib>ISHII, Hideshi</creatorcontrib><creatorcontrib>DOKI, Yuichiro</creatorcontrib><creatorcontrib>KUWANO, Hiroyuki</creatorcontrib><creatorcontrib>MORI, Masaki</creatorcontrib><title>MicroRNA miR-125b is a prognostic marker in human colorectal cancer</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 colorectal cancer cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced tumor size and tumor invasion compared to the low miR-125b expression group (P<0.05). In addition, the high miR-125b expression group had a significantly poorer prognosis compared to the low expression group (P<0.05). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. Our analysis of miR-125b focused on the miR-125b/p53 pathway. In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells. These data show that miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - genetics</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genes, p53</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - physiology</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>RNA, Messenger - analysis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Genes, p53</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - physiology</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>RNA, Messenger - analysis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>NISHIDA, Naohiro</creatorcontrib><creatorcontrib>YOKOBORI, Takehiko</creatorcontrib><creatorcontrib>MIMORI, Koshi</creatorcontrib><creatorcontrib>SUDO, Tomoya</creatorcontrib><creatorcontrib>TANAKA, Fumiaki</creatorcontrib><creatorcontrib>SHIBATA, Kohei</creatorcontrib><creatorcontrib>ISHII, Hideshi</creatorcontrib><creatorcontrib>DOKI, Yuichiro</creatorcontrib><creatorcontrib>KUWANO, Hiroyuki</creatorcontrib><creatorcontrib>MORI, Masaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NISHIDA, Naohiro</au><au>YOKOBORI, Takehiko</au><au>MIMORI, Koshi</au><au>SUDO, Tomoya</au><au>TANAKA, Fumiaki</au><au>SHIBATA, Kohei</au><au>ISHII, Hideshi</au><au>DOKI, Yuichiro</au><au>KUWANO, Hiroyuki</au><au>MORI, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA miR-125b is a prognostic marker in human colorectal cancer</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>38</volume><issue>5</issue><spage>1437</spage><epage>1443</epage><pages>1437-1443</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 colorectal cancer cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced tumor size and tumor invasion compared to the low miR-125b expression group (P<0.05). In addition, the high miR-125b expression group had a significantly poorer prognosis compared to the low expression group (P<0.05). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. Our analysis of miR-125b focused on the miR-125b/p53 pathway. In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells. These data show that miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients.</abstract><cop>Athens</cop><pub>Editorial Academy of the International Journal of Oncology</pub><pmid>21399871</pmid><doi>10.3892/ijo.2011.969</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Cell Line, Tumor Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Cyclin-Dependent Kinase Inhibitor p21 - genetics Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen Genes, p53 Humans Male Medical sciences MicroRNAs - genetics MicroRNAs - physiology Middle Aged Prognosis RNA, Messenger - analysis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | MicroRNA miR-125b is a prognostic marker in human colorectal cancer |
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