State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma
Heat shock factor 1 (HSF1) is responsible for expres-- sion of a large class of heat shock proteins that have been implicated in the malignant phenotype of human cancers. Little is known about the effect of a high level of HSF1 on the behavior of oral squamous cell carcinoma (OSCC). In this study, w...
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| Veröffentlicht in: | International journal of oncology 2012-01, Vol.40 (1), p.47-52 |
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| creator | ISHIWATA, Junya KASAMATSU, Atsushi SHIIBA, Masashi TANZAWA, Hideki UZAWA, Katsuhiro SAKUMA, Kentaro IYODA, Manabu YAMATOJI, Masanobu USUKURA, Katsuya ISHIGE, Shunsaku SHIMIZU, Toshihiro YAMANO, Yukio OGAWARA, Katsunori |
| description | Heat shock factor 1 (HSF1) is responsible for expres-- sion of a large class of heat shock proteins that have been implicated in the malignant phenotype of human cancers. Little is known about the effect of a high level of HSF1 on the behavior of oral squamous cell carcinoma (OSCC). In this study, we assessed the value of HSF1 for predicting clinical outcomes in OSCC. Quantitative reverse transcriptase-polymerase chain reaction and Western blotting showed that the expressions of HSF1 mRNA and protein in OSCC-derived cell lines (HSC-2, HSC-3, HSC-4, Sa3, Ca9-22, KON and Ho-1-u-1) were elevated compared with those in human normal oral keratinocytes (P |
| doi_str_mv | 10.3892/ijo.2011.1178 |
| format | Article |
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Little is known about the effect of a high level of HSF1 on the behavior of oral squamous cell carcinoma (OSCC). In this study, we assessed the value of HSF1 for predicting clinical outcomes in OSCC. Quantitative reverse transcriptase-polymerase chain reaction and Western blotting showed that the expressions of HSF1 mRNA and protein in OSCC-derived cell lines (HSC-2, HSC-3, HSC-4, Sa3, Ca9-22, KON and Ho-1-u-1) were elevated compared with those in human normal oral keratinocytes (P<0.05). Similar to in vitro data, HSF1 mRNA expression in primary OSCCs (n=50) was significantly greater than in normal counterparts (P<0.05). Since HSF1 was observed in the nucleus and cytoplasm by immu-- nohistochemistry, we investigated the correlation between the HSF1 expression status at each subcellular location and the clinical behavior of OSCCs. Among the clinical classifications, higher nuclear HSF1 expression was closely related to tumor size and histopathologic types (P<0.05). These results showed for the first time that nuclear HSF1 expression may contribute to cancer progression and that HSF1 might be a potential diagnostic biomarker and a therapeutic target for OSCCs.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2011.1178</identifier><identifier>PMID: 21879256</identifier><language>eng</language><publisher>Athens: Editorial Academy of the International Journal of Oncology</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Blotting, Western ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Cell Line, Tumor ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - genetics ; Heat Shock Transcription Factors ; Humans ; Immunohistochemistry ; Keratinocytes - metabolism ; Medical sciences ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - genetics ; Mouth Neoplasms - metabolism ; Otorhinolaryngology. Stomatology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Transcription Factors - biosynthesis ; Transcription Factors - genetics ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>International journal of oncology, 2012-01, Vol.40 (1), p.47-52</ispartof><rights>2015 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-d985b3e997de5efa2869c2aea3413bfa6cb947c8fd1135de134795e0ed036f223</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25517821$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21879256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISHIWATA, Junya</creatorcontrib><creatorcontrib>KASAMATSU, Atsushi</creatorcontrib><creatorcontrib>SHIIBA, Masashi</creatorcontrib><creatorcontrib>TANZAWA, Hideki</creatorcontrib><creatorcontrib>UZAWA, Katsuhiro</creatorcontrib><creatorcontrib>SAKUMA, Kentaro</creatorcontrib><creatorcontrib>IYODA, Manabu</creatorcontrib><creatorcontrib>YAMATOJI, Masanobu</creatorcontrib><creatorcontrib>USUKURA, Katsuya</creatorcontrib><creatorcontrib>ISHIGE, Shunsaku</creatorcontrib><creatorcontrib>SHIMIZU, Toshihiro</creatorcontrib><creatorcontrib>YAMANO, Yukio</creatorcontrib><creatorcontrib>OGAWARA, Katsunori</creatorcontrib><title>State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Heat shock factor 1 (HSF1) is responsible for expres-- sion of a large class of heat shock proteins that have been implicated in the malignant phenotype of human cancers. Little is known about the effect of a high level of HSF1 on the behavior of oral squamous cell carcinoma (OSCC). In this study, we assessed the value of HSF1 for predicting clinical outcomes in OSCC. Quantitative reverse transcriptase-polymerase chain reaction and Western blotting showed that the expressions of HSF1 mRNA and protein in OSCC-derived cell lines (HSC-2, HSC-3, HSC-4, Sa3, Ca9-22, KON and Ho-1-u-1) were elevated compared with those in human normal oral keratinocytes (P<0.05). Similar to in vitro data, HSF1 mRNA expression in primary OSCCs (n=50) was significantly greater than in normal counterparts (P<0.05). Since HSF1 was observed in the nucleus and cytoplasm by immu-- nohistochemistry, we investigated the correlation between the HSF1 expression status at each subcellular location and the clinical behavior of OSCCs. Among the clinical classifications, higher nuclear HSF1 expression was closely related to tumor size and histopathologic types (P<0.05). These results showed for the first time that nuclear HSF1 expression may contribute to cancer progression and that HSF1 might be a potential diagnostic biomarker and a therapeutic target for OSCCs.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Blotting, Western</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Cell Line, Tumor</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Heat Shock Transcription Factors</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratinocytes - metabolism</subject><subject>Medical sciences</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcription Factors - genetics</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1PwzAQgGELgWgpjKzIC2OKz46TeEQVX1IlBmCOrs6Zpk3iYqcI_j2pWmA6D49Pp5exSxBTVRh5U6_8VAqAKUBeHLEx5AYSmUp1PLwFmCRLlRmxsxhXQkitBZyykYQiN1JnY7Z86bEn7h1fEvY8Lr1dc4e294EDp69NoBhr33GMHPlmO-j6k3hV43vnY19b3mJYU-Bu-OADNjx-bLH128gtNQ23GGzd-RbP2YnDJtLFYU7Y2_3d6-wxmT8_PM1u54lVGfRJZQq9UGRMXpEmh7LIjJVIqFJQC4eZXZg0t4WrAJSuCFSaG02CKqEyJ6WasGS_1wYfYyBXbkI93Phdgih3xcqhWLkrVu6KDf5q7zfbRUvVn_5NNIDrA8BosXEBO1vHf6f1sEaC-gHZF3V0</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>ISHIWATA, Junya</creator><creator>KASAMATSU, Atsushi</creator><creator>SHIIBA, Masashi</creator><creator>TANZAWA, Hideki</creator><creator>UZAWA, Katsuhiro</creator><creator>SAKUMA, Kentaro</creator><creator>IYODA, Manabu</creator><creator>YAMATOJI, Masanobu</creator><creator>USUKURA, Katsuya</creator><creator>ISHIGE, Shunsaku</creator><creator>SHIMIZU, Toshihiro</creator><creator>YAMANO, Yukio</creator><creator>OGAWARA, Katsunori</creator><general>Editorial Academy of the International Journal of Oncology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20120101</creationdate><title>State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma</title><author>ISHIWATA, Junya ; KASAMATSU, Atsushi ; SHIIBA, Masashi ; TANZAWA, Hideki ; UZAWA, Katsuhiro ; SAKUMA, Kentaro ; IYODA, Manabu ; YAMATOJI, Masanobu ; USUKURA, Katsuya ; ISHIGE, Shunsaku ; SHIMIZU, Toshihiro ; YAMANO, Yukio ; OGAWARA, Katsunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-d985b3e997de5efa2869c2aea3413bfa6cb947c8fd1135de134795e0ed036f223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Blotting, Western</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Cell Line, Tumor</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Heat Shock Transcription Factors</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratinocytes - metabolism</topic><topic>Medical sciences</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - genetics</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>online_resources</toplevel><creatorcontrib>ISHIWATA, Junya</creatorcontrib><creatorcontrib>KASAMATSU, Atsushi</creatorcontrib><creatorcontrib>SHIIBA, Masashi</creatorcontrib><creatorcontrib>TANZAWA, Hideki</creatorcontrib><creatorcontrib>UZAWA, Katsuhiro</creatorcontrib><creatorcontrib>SAKUMA, Kentaro</creatorcontrib><creatorcontrib>IYODA, Manabu</creatorcontrib><creatorcontrib>YAMATOJI, Masanobu</creatorcontrib><creatorcontrib>USUKURA, Katsuya</creatorcontrib><creatorcontrib>ISHIGE, Shunsaku</creatorcontrib><creatorcontrib>SHIMIZU, Toshihiro</creatorcontrib><creatorcontrib>YAMANO, Yukio</creatorcontrib><creatorcontrib>OGAWARA, Katsunori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHIWATA, Junya</au><au>KASAMATSU, Atsushi</au><au>SHIIBA, Masashi</au><au>TANZAWA, Hideki</au><au>UZAWA, Katsuhiro</au><au>SAKUMA, Kentaro</au><au>IYODA, Manabu</au><au>YAMATOJI, Masanobu</au><au>USUKURA, Katsuya</au><au>ISHIGE, Shunsaku</au><au>SHIMIZU, Toshihiro</au><au>YAMANO, Yukio</au><au>OGAWARA, Katsunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>40</volume><issue>1</issue><spage>47</spage><epage>52</epage><pages>47-52</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Heat shock factor 1 (HSF1) is responsible for expres-- sion of a large class of heat shock proteins that have been implicated in the malignant phenotype of human cancers. Little is known about the effect of a high level of HSF1 on the behavior of oral squamous cell carcinoma (OSCC). In this study, we assessed the value of HSF1 for predicting clinical outcomes in OSCC. Quantitative reverse transcriptase-polymerase chain reaction and Western blotting showed that the expressions of HSF1 mRNA and protein in OSCC-derived cell lines (HSC-2, HSC-3, HSC-4, Sa3, Ca9-22, KON and Ho-1-u-1) were elevated compared with those in human normal oral keratinocytes (P<0.05). Similar to in vitro data, HSF1 mRNA expression in primary OSCCs (n=50) was significantly greater than in normal counterparts (P<0.05). Since HSF1 was observed in the nucleus and cytoplasm by immu-- nohistochemistry, we investigated the correlation between the HSF1 expression status at each subcellular location and the clinical behavior of OSCCs. Among the clinical classifications, higher nuclear HSF1 expression was closely related to tumor size and histopathologic types (P<0.05). These results showed for the first time that nuclear HSF1 expression may contribute to cancer progression and that HSF1 might be a potential diagnostic biomarker and a therapeutic target for OSCCs.</abstract><cop>Athens</cop><pub>Editorial Academy of the International Journal of Oncology</pub><pmid>21879256</pmid><doi>10.3892/ijo.2011.1178</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1019-6439 |
| ispartof | International journal of oncology, 2012-01, Vol.40 (1), p.47-52 |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Blotting, Western Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Line, Tumor DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Heat Shock Transcription Factors Humans Immunohistochemistry Keratinocytes - metabolism Medical sciences Mouth Neoplasms - diagnosis Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Otorhinolaryngology. Stomatology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma |
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