P-glycoprotein and survivin simultaneously regulate vincristine-induced apoptosis in chronic myeloid leukemia cells

Overexpression of P-glycoprotein (Pgp/ABCB1) in tumor cells is associated with a classic phenotype of multidrug resistance (MDR). Moreover, some members of the inhibitor of apoptosis protein (IAP) family, such as survivin, contribute to an apoptosis-resistant phenotype, by inhibiting chemotherapy-in...

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Veröffentlicht in:	International journal of oncology 2011-10, Vol.39 (4), p.925-933
Hauptverfasser:	DE SOUZA, Paloma Silva, DA CUNHA VASCONCELOS, Flavia, DE SOUZA REIS, Flaviana Ruade, DE MORAES, Gabriela Nestal, CIUVALSCHI MAIA, Raquel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Cell Division - drug effects Cell Line, Tumor Cell Survival - drug effects Drug Resistance, Multiple Drug Resistance, Neoplasm G2 Phase - drug effects Hematologic and hematopoietic diseases Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Tumors Vincristine - pharmacology X-Linked Inhibitor of Apoptosis Protein - genetics
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