Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

In solid malignant tumors, lactate has been identified as a prognostic parameter for metastasis and overall survival of patients. To investigate the effects of lactate on tumor cell migration, Boyden chamber assays were applied. We could show here that lactate enhances tumor cell motility of head an...

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Veröffentlicht in:	International journal of oncology 2011-08, Vol.39 (2), p.453-463
Hauptverfasser:	GOETZE, Kristina, WALENTA, Stefan, KSLAZKIEWICZ, Magdalena, KUNZ-SCHUGHART, Leoni A, MUELLER-KLIESER, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Cell Movement - drug effects Cytokines - secretion Humans Integrin beta Chains - metabolism Lactic Acid - pharmacology Medical sciences Monocytes - drug effects Monocytes - metabolism Neoplasms - metabolism Tumors
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