FLT-PET may not be a reliable indicator of therapeutic response in p53-null malignancy

FDG (18F-deoxy-glucose) is the current gold standard for PET imaging. FLT (3'-deoxy-3'-(18F-fluorothymidine), a PET imaging marker of proliferation, has been proposed as an alternative to FDG for the assessment of therapeutic response. We examined the therapeutic predictive value of FLT-PE...

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Veröffentlicht in:	International journal of oncology 2011-07, Vol.39 (1), p.91-100
Hauptverfasser:	KATZ, Sharyn I, LANLAN ZHOU, FERRARA, Thomas A, WENGE WANG, MAYES, Patrick A, SMITH, Charles D, EL-DEIRY, Wafik S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Apoptosis - genetics Benzenesulfonates - pharmacology Benzenesulfonates - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cisplatin - pharmacology Disease Models, Animal Fluorine Radioisotopes - metabolism Fluorine Radioisotopes - standards Fluorodeoxyglucose F18 - metabolism Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Mice Niacinamide - analogs & derivatives Pharmacology. Drug treatments Phenylurea Compounds Positron-Emission Tomography - standards Pyridines - pharmacology Pyridines - therapeutic use Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use TNF-Related Apoptosis-Inducing Ligand - pharmacology TNF-Related Apoptosis-Inducing Ligand - therapeutic use Tumor Suppressor Protein p53 - genetics Tumors Xenograft Model Antitumor Assays
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