CuZnSOD and MnSOD inhibit metabolic stress-induced necrosis and multicellular tumour spheroid growth

CuZnSOD and MnSOD have been shown to exert tumour suppressive activities; however, their exact molecular mechanism is still unclear. We investigated the molecular mechanism underlying the tumour suppressive activities of CuZnSOD and MnSOD using multicellular tumour spheroid (MTS), an in vitro tumour...

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Veröffentlicht in:	International journal of oncology 2010-07, Vol.37 (1), p.195-202
Hauptverfasser:	SU YEON LEE, HYUN MIN JEON, HO SUNG KANG, CHO HEE KIM, EUI KYONG JEONG, MIN KYUNG JU, SONG YI PARK, SEUNG YOUN JUNG, YUNG JIN KIM, LIM, Sung-Chul, SONG IY HAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Culture Techniques Cell Proliferation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HMGB1 Protein - metabolism Humans Medical sciences Mitochondria - metabolism Mitochondria - pathology Necrosis - genetics Necrosis - metabolism Necrosis - pathology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Reactive Oxygen Species - metabolism Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stress, Physiological - genetics Stress, Physiological - physiology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase - physiology Transfection Tumor Cells, Cultured Tumors Up-Regulation - physiology
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