Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor

Daclatasvir (BMS-790052) is an investigational molecule that inhibits the HCV NS5A protein and shows potent antiviral activity apparently across all HCV genotypes. Selection of drug resistance mutations has been reported only for HCV genotype 1, and no information exists for other HCV variants and/o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antiviral therapy 2012-01, Vol.17 (5), p.921-926
Hauptverfasser:	PLAZA, Zulema, SORIANO, Vincent, VISPO, Eugenia, MAR GONZALEZ, Maria Del, BARREIRO, Pablo, SECLEN, Eduardo, POVEDA, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Carbamates Coinfection Drug Resistance, Viral - genetics Female Genotype Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - virology HIV Infections - virology Human viral diseases Humans Imidazoles - pharmacology Imidazoles - therapeutic use Infectious diseases Inhibitory Concentration 50 Male Medical sciences Middle Aged Mutation Pharmacology. Drug treatments Polymorphism, Single Nucleotide Prevalence Pyrrolidines Valine - analogs & derivatives Viral diseases Viral hepatitis Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!