Low rates of nucleoside reverse transcriptase inhibitor resistance in a well―monitored cohort in South Africa on antiretroviral therapy

The emergence of complex HIV-1 drug resistance mutations has been linked to the duration of time patients are on a failing antiretroviral drug regimen. This study reports on resistance profiles in a closely monitored subtype C infected cohort. A total of 812 participants were enrolled into the CIPRA...

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Veröffentlicht in:	Antiviral therapy 2012-01, Vol.17 (2), p.313-320
Hauptverfasser:	WALLIS, Carole L, PAPATHANASOPOLOUS, Maria A, STEVENS, Wendy, FOX, Matthew, CONRADIE, Francesca, IVE, Prudence, ORRELL, Catherine, ZEINECKER, Jennifer, SANNE, Ian, WOOD, Robin, MCLNTYRE, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Benzoxazines - pharmacology Benzoxazines - therapeutic use Biological and medical sciences CD4 Lymphocyte Count Drug Resistance, Viral - genetics Female Genotype HIV Infections - drug therapy HIV Infections - genetics HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lamivudine - pharmacology Lamivudine - therapeutic use Male Medical sciences Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - pharmacology Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - genetics South Africa Stavudine - pharmacology Stavudine - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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