1,2,3-Triazoles as leaving groups: S N Ar reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles
A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in S Ar reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The products were isolated in yields up to 87%. T...
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| Veröffentlicht in: | Beilstein journal of organic chemistry 2021-02, Vol.17, p.410-419 |
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| container_title | Beilstein journal of organic chemistry |
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| creator | Cīrule, Dace Novosjolova, Irina Bizdēna, Ērika Turks, Māris |
| description | A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in S
Ar reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The products were isolated in yields up to 87%. The developed C-O and C-C bond forming reactions clearly show the ability of the 1,2,3-triazolyl ring at the C6 position of purine to act as leaving group. |
| doi_str_mv | 10.3762/bjoc.17.37 |
| format | Article |
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| title | 1,2,3-Triazoles as leaving groups: S N Ar reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles |
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