INDUCTION OF CHRONIC KIDNEY FAILURE IN A LONG-TERM PERITONEAL EXPOSURE MODEL IN THE RAT: EFFECTS ON FUNCTIONAL AND STRUCTURAL PERITONEAL ALTERATIONS

A long-term peritoneal exposure model has been developed in Wistar rats. Chronic daily exposure to 3.86% glucose based, lactate buffered, conventional dialysis solutions is possible for up to 20 weeks and induces morphological abnormalities similar to those in long-term peritoneal dialysis (PD) pati...

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Veröffentlicht in:	Peritoneal dialysis international 2010-09, Vol.30 (5), p.558-569
Hauptverfasser:	VRTOVSNIK, François, COESTER, Annemieke M, LOPES-BARRETO, Deirisa, DE WAART, Dirk R, VAN DER WAL, Allard C, STRUIJK, Dirk G, KREDIET, Raymond T, ZWEERS, Machteld M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Biopsy, Needle Catheters, Indwelling Disease Models, Animal Emergency and intensive care: renal failure. Dialysis management Hemodialysis Solutions - metabolism Hemodialysis Solutions - pharmacology Immunohistochemistry Intensive care medicine Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Kidney Function Tests Linear Models Male Medical sciences Nephrectomy - methods Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Peritoneal Dialysis - adverse effects Peritoneal Dialysis - methods Peritoneal Diseases - etiology Peritoneal Diseases - pathology Peritoneum - drug effects Peritoneum - pathology Random Allocation Rats Rats, Wistar Reference Values Renal failure Risk Factors Time Factors
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