Predictive Value of the AMH Level and Serum Estradiol for Ovarian Hyperstimulation Syndrome in the Assisted Human Reproduction

The ovarian hyperstimulation syndrome (OHSS) is one of the major complications which occurs as a result of controlled ovarian stimulation (COS) in the assisted human reproduction. There are several factors including age, body mass index (BMI), plasma estradiol level, the anti-mullerian hormone (AMH) level and the antral follicle count (AFC), which can be used to identify the cases with high risk for this complication. The purpose of the study is to establish the predictive value of AMH for the development of OHSS before COS as well as its association with the plasma estradiol level during stimulation. The study group included 155 COS cycles using gonadotropin-releasing hormone (GnRH) agonist protocols, and analyzed the predictive value of the mentioned parameters for OHSS. The serum AMH level is superior to age and BMI for identification of patients with high risk for OHSS before starting the ovulation stimulation, and the cut-off level is 3.78ng/mlLwith 91.1% sensibility and 85.2% specificity.