Repetition of microbiological tests in suspect of SARS-CoV-2 infection: utility of a score based on clinical probability

The diagnosis of SARS-CoV-2 infection presents some limitations. RT-PCR in nasopharyngeal swabs is considered the gold standard for the diagnosis, although it can have false negative results. We aimed to analyze the accuracy of repeating nasopharyngeal swabs based on different clinical probabilities...

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Veröffentlicht in:Revista española de quimioterapia 2020-12, Vol.33 (6), p.410-414
Hauptverfasser: Pardo Lledias, J, Ayarza, L, González-García, P, Salmón González, Z, Calvo Montes, J, Gozalo Marguello, M, Hernández Hernández, J L, Olmos Martínez, J M
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Sprache:eng ; spa
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Zusammenfassung:The diagnosis of SARS-CoV-2 infection presents some limitations. RT-PCR in nasopharyngeal swabs is considered the gold standard for the diagnosis, although it can have false negative results. We aimed to analyze the accuracy of repeating nasopharyngeal swabs based on different clinical probabilities. Retrospective observational study of the first patients admitted to a two COVID Internal Medicine wards at the University Hospital Marqués de Valdecilla, Santander, from March to April 2020. RT-PCR targering E, N, RdRP and ORFab1 genes and antibody tests detecting IgG. A total of 145 hospitalized patients with suspected SARS-Cov2 infection were admitted and in 98 (67.5%) diagnosis was confirmed. The independent predictive variables for SARS-CoV-2 infection were: epidemiological contact, clinical presentation as pneumonia, absence of pneumonia in the last year, onset of symptoms > 7 days, two or more of the following symptoms -dyspnea, cough or fever- and serum lactate dehydrogenase levels >350 U/L (p
ISSN:0214-3429
1988-9518
DOI:10.37201/req/080.2020