Evaluation of variation of D-dimer levels in COVID-19 patients to predict the disease outcome in a hospital based study
Objectives: To determine the variation of d-dimers in COVID-19. To determine the contribution of demographic factors (age and gender) toward an elevated d-dimers values. To determine the probability of surviving in different age groups in COVID-19, with d-dimer > 0.5 µg/ml. Methodology: A total...
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| creator | Khan, Shahtaj Khan, Hamzullah Khan, Saba Akhtar, Mansoor |
| description | Objectives: To determine the variation of d-dimers in COVID-19.
To determine the contribution of demographic factors (age and gender) toward an elevated d-dimers values. To determine the probability of surviving in different age groups in COVID-19, with d-dimer > 0.5 µg/ml.
Methodology: A total of 193 patients were enrolled from COVID-19 isolation units, Hayatabad medical complex Peshawar, whose d-dimer levels were performed as per instructions of the treating physician and were followed. Relevant information’s were recorded on a pre-designed performa prepared in accordance with the objectives of the study.
Results: Out of total 193 patients 152(78.8%) were males and 41(21.2%) females. 94(48.7%) patients were in the age range 35-55 y while 76(39.4%) patients had age more than 55 y. Regarding d-dimer readings, 162(83.9%) had d-dimer levels more than 0.5 µg/ml. The mean with standard deviation of age of the patients was 52 ± 13 y. The mean with standard deviation of d-dimer values of the patients was 4.9 ± 13.3 µg/ml. It was observed that, the relative risk of deranged values of d-dimers was 1.18 (rr = 1.18) in patients with age > 55 y. Similarly in female gender the relative risk of higher values of d-dimers above normal was 1.26 (rr = 1.26) without reaching a statistically significant p-value (p = 0.48). The probability of worse outcome in term of death was 2.06 times more in patients with d dimers > 0.5 µg/ml (OR = 2.06). Furthermore the probability of surviving was 90-100% by age < 50 y, 80% in age range 51-60 y, 45% in age range 61-70 y and 30% at age > 80 y.
Conclusion: The deranged d-dimer levels were noted in 84% of the COVID-19 patients. Age > 55 y and female gender are at higher risk of deranged d-dimers and further consequences. Survival rate of patients with deranged d-dimers drops to 30% in patients with age > 80 y, 45% at age < 70 y.
Key word: COVID-19, D-dimers, survival rate, prognostic values
Anaesth. pain intensive care 2020;24(5):
Received: 20 June 2020, Reviewed: 24, 28 June 2020, Accepted: 1 July 2020 |
| doi_str_mv | 10.35975/apic.v24i5.1355 |
| format | Article |
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To determine the contribution of demographic factors (age and gender) toward an elevated d-dimers values. To determine the probability of surviving in different age groups in COVID-19, with d-dimer > 0.5 µg/ml.
Methodology: A total of 193 patients were enrolled from COVID-19 isolation units, Hayatabad medical complex Peshawar, whose d-dimer levels were performed as per instructions of the treating physician and were followed. Relevant information’s were recorded on a pre-designed performa prepared in accordance with the objectives of the study.
Results: Out of total 193 patients 152(78.8%) were males and 41(21.2%) females. 94(48.7%) patients were in the age range 35-55 y while 76(39.4%) patients had age more than 55 y. Regarding d-dimer readings, 162(83.9%) had d-dimer levels more than 0.5 µg/ml. The mean with standard deviation of age of the patients was 52 ± 13 y. The mean with standard deviation of d-dimer values of the patients was 4.9 ± 13.3 µg/ml. It was observed that, the relative risk of deranged values of d-dimers was 1.18 (rr = 1.18) in patients with age > 55 y. Similarly in female gender the relative risk of higher values of d-dimers above normal was 1.26 (rr = 1.26) without reaching a statistically significant p-value (p = 0.48). The probability of worse outcome in term of death was 2.06 times more in patients with d dimers > 0.5 µg/ml (OR = 2.06). Furthermore the probability of surviving was 90-100% by age < 50 y, 80% in age range 51-60 y, 45% in age range 61-70 y and 30% at age > 80 y.
Conclusion: The deranged d-dimer levels were noted in 84% of the COVID-19 patients. Age > 55 y and female gender are at higher risk of deranged d-dimers and further consequences. Survival rate of patients with deranged d-dimers drops to 30% in patients with age > 80 y, 45% at age < 70 y.
Key word: COVID-19, D-dimers, survival rate, prognostic values
Anaesth. pain intensive care 2020;24(5):
Received: 20 June 2020, Reviewed: 24, 28 June 2020, Accepted: 1 July 2020</description><identifier>ISSN: 1607-8322</identifier><identifier>EISSN: 2220-5799</identifier><identifier>DOI: 10.35975/apic.v24i5.1355</identifier><language>eng</language><ispartof>Anaesthesia, pain & intensive care, 2020-10, Vol.24 (5)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Khan, Shahtaj</creatorcontrib><creatorcontrib>Khan, Hamzullah</creatorcontrib><creatorcontrib>Khan, Saba</creatorcontrib><creatorcontrib>Akhtar, Mansoor</creatorcontrib><title>Evaluation of variation of D-dimer levels in COVID-19 patients to predict the disease outcome in a hospital based study</title><title>Anaesthesia, pain & intensive care</title><description>Objectives: To determine the variation of d-dimers in COVID-19.
To determine the contribution of demographic factors (age and gender) toward an elevated d-dimers values. To determine the probability of surviving in different age groups in COVID-19, with d-dimer > 0.5 µg/ml.
Methodology: A total of 193 patients were enrolled from COVID-19 isolation units, Hayatabad medical complex Peshawar, whose d-dimer levels were performed as per instructions of the treating physician and were followed. Relevant information’s were recorded on a pre-designed performa prepared in accordance with the objectives of the study.
Results: Out of total 193 patients 152(78.8%) were males and 41(21.2%) females. 94(48.7%) patients were in the age range 35-55 y while 76(39.4%) patients had age more than 55 y. Regarding d-dimer readings, 162(83.9%) had d-dimer levels more than 0.5 µg/ml. The mean with standard deviation of age of the patients was 52 ± 13 y. The mean with standard deviation of d-dimer values of the patients was 4.9 ± 13.3 µg/ml. It was observed that, the relative risk of deranged values of d-dimers was 1.18 (rr = 1.18) in patients with age > 55 y. Similarly in female gender the relative risk of higher values of d-dimers above normal was 1.26 (rr = 1.26) without reaching a statistically significant p-value (p = 0.48). The probability of worse outcome in term of death was 2.06 times more in patients with d dimers > 0.5 µg/ml (OR = 2.06). Furthermore the probability of surviving was 90-100% by age < 50 y, 80% in age range 51-60 y, 45% in age range 61-70 y and 30% at age > 80 y.
Conclusion: The deranged d-dimer levels were noted in 84% of the COVID-19 patients. Age > 55 y and female gender are at higher risk of deranged d-dimers and further consequences. Survival rate of patients with deranged d-dimers drops to 30% in patients with age > 80 y, 45% at age < 70 y.
Key word: COVID-19, D-dimers, survival rate, prognostic values
Anaesth. pain intensive care 2020;24(5):
Received: 20 June 2020, Reviewed: 24, 28 June 2020, Accepted: 1 July 2020</description><issn>1607-8322</issn><issn>2220-5799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNo9kE9rAjEQxUNpoWK995gvsDZ_N8mxqG0FwYv0usRkFlNWsyRxi9--qy2dy2PemxmYH0LPlMy5NEq-2D64-cBEkHPKpbxDE8YYqaQy5h5NaE1UpTljj2iW8xcZSwpNpZyg79Vgu7MtIZ5wbPFgU_hvlpUPR0i4gwG6jMMJL7af62VFDe7HITiVjEvEfQIfXMHlANiHDDYDjufi4hGuOxYfYu5DsR3ej5HHuZz95Qk9tLbLMPvTKdq9rXaLj2qzfV8vXjeVo6YulbV-r7UAw31NrDeUSKUFrUdftUxoreT4bqulE8A5WLKnTglWE-Fr5hSfIvJ71qWYc4K26VM42nRpKGlu6JoruuaGrrmi4z_QQ2ON</recordid><startdate>20201006</startdate><enddate>20201006</enddate><creator>Khan, Shahtaj</creator><creator>Khan, Hamzullah</creator><creator>Khan, Saba</creator><creator>Akhtar, Mansoor</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201006</creationdate><title>Evaluation of variation of D-dimer levels in COVID-19 patients to predict the disease outcome in a hospital based study</title><author>Khan, Shahtaj ; Khan, Hamzullah ; Khan, Saba ; Akhtar, Mansoor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c196t-aadb884e93d60ad910578416aad7f248875355f85c4e33ea0b1c742604d62c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Shahtaj</creatorcontrib><creatorcontrib>Khan, Hamzullah</creatorcontrib><creatorcontrib>Khan, Saba</creatorcontrib><creatorcontrib>Akhtar, Mansoor</creatorcontrib><collection>CrossRef</collection><jtitle>Anaesthesia, pain & intensive care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Shahtaj</au><au>Khan, Hamzullah</au><au>Khan, Saba</au><au>Akhtar, Mansoor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of variation of D-dimer levels in COVID-19 patients to predict the disease outcome in a hospital based study</atitle><jtitle>Anaesthesia, pain & intensive care</jtitle><date>2020-10-06</date><risdate>2020</risdate><volume>24</volume><issue>5</issue><issn>1607-8322</issn><eissn>2220-5799</eissn><abstract>Objectives: To determine the variation of d-dimers in COVID-19.
To determine the contribution of demographic factors (age and gender) toward an elevated d-dimers values. To determine the probability of surviving in different age groups in COVID-19, with d-dimer > 0.5 µg/ml.
Methodology: A total of 193 patients were enrolled from COVID-19 isolation units, Hayatabad medical complex Peshawar, whose d-dimer levels were performed as per instructions of the treating physician and were followed. Relevant information’s were recorded on a pre-designed performa prepared in accordance with the objectives of the study.
Results: Out of total 193 patients 152(78.8%) were males and 41(21.2%) females. 94(48.7%) patients were in the age range 35-55 y while 76(39.4%) patients had age more than 55 y. Regarding d-dimer readings, 162(83.9%) had d-dimer levels more than 0.5 µg/ml. The mean with standard deviation of age of the patients was 52 ± 13 y. The mean with standard deviation of d-dimer values of the patients was 4.9 ± 13.3 µg/ml. It was observed that, the relative risk of deranged values of d-dimers was 1.18 (rr = 1.18) in patients with age > 55 y. Similarly in female gender the relative risk of higher values of d-dimers above normal was 1.26 (rr = 1.26) without reaching a statistically significant p-value (p = 0.48). The probability of worse outcome in term of death was 2.06 times more in patients with d dimers > 0.5 µg/ml (OR = 2.06). Furthermore the probability of surviving was 90-100% by age < 50 y, 80% in age range 51-60 y, 45% in age range 61-70 y and 30% at age > 80 y.
Conclusion: The deranged d-dimer levels were noted in 84% of the COVID-19 patients. Age > 55 y and female gender are at higher risk of deranged d-dimers and further consequences. Survival rate of patients with deranged d-dimers drops to 30% in patients with age > 80 y, 45% at age < 70 y.
Key word: COVID-19, D-dimers, survival rate, prognostic values
Anaesth. pain intensive care 2020;24(5):
Received: 20 June 2020, Reviewed: 24, 28 June 2020, Accepted: 1 July 2020</abstract><doi>10.35975/apic.v24i5.1355</doi><oa>free_for_read</oa></addata></record> |
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| title | Evaluation of variation of D-dimer levels in COVID-19 patients to predict the disease outcome in a hospital based study |
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