Investigation of damage in vascular endothelial cells caused by lipid bubbles under ultrasound irradiation to verify the protective effect on cells
We investigated the viability of vascular endothelial cells engrafted on the basement membrane of a flow channel to verify the protective effect from cell damage under ultrasound exposure with a frequency of 3 MHz and a maximum sound pressure of 400 kPa-pp. We used two types of lipid bubbles (LBs),...
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| Veröffentlicht in: | Japanese Journal of Applied Physics 2024-04, Vol.63 (4), p.4 |
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| container_title | Japanese Journal of Applied Physics |
| container_volume | 63 |
| creator | Ogawa, Narumi Ito, Yoshiki Watanabe, Shunya Araki, Shinnnosuke Yoshida, Naoya Konishi, Kota Noguchi, Ayako Miyamoto, Yoshitaka Omata, Daiki Suzuki, Ryo Masuda, Kohji |
| description | We investigated the viability of vascular endothelial cells engrafted on the basement membrane of a flow channel to verify the protective effect from cell damage under ultrasound exposure with a frequency of 3 MHz and a maximum sound pressure of 400 kPa-pp. We used two types of lipid bubbles (LBs), namely LBs (+) attached to the cells and LBs (–) not attached to the cells. We confirmed that the engrafted cells on the basement remained after ultrasound exposure and were resistant to flow. We found significant cell damage using LBs (–) regardless of the flow condition, whereas cell damage was not observed with LBs (+). A difference in irradiation direction of ultrasound was not detected. By making use of the adhesion of LBs (+) on the cells, since there was a significant increase in cell survival rate, we prove the potential for the adhesion of LBs (+) to protect cells from cell damage. |
| doi_str_mv | 10.35848/1347-4065/ad2c66 |
| format | Article |
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We confirmed that the engrafted cells on the basement remained after ultrasound exposure and were resistant to flow. We found significant cell damage using LBs (–) regardless of the flow condition, whereas cell damage was not observed with LBs (+). A difference in irradiation direction of ultrasound was not detected. By making use of the adhesion of LBs (+) on the cells, since there was a significant increase in cell survival rate, we prove the potential for the adhesion of LBs (+) to protect cells from cell damage.</description><identifier>ISSN: 0021-4922</identifier><identifier>EISSN: 1347-4065</identifier><identifier>DOI: 10.35848/1347-4065/ad2c66</identifier><identifier>CODEN: JJAPB6</identifier><language>eng</language><publisher>Tokyo: IOP Publishing</publisher><subject>Adhesion ; Basements ; Bubbles ; Endothelial cells ; Flow resistance ; Lipids ; Radiation damage ; Sound pressure ; Ultrasonic imaging</subject><ispartof>Japanese Journal of Applied Physics, 2024-04, Vol.63 (4), p.4</ispartof><rights>2024 The Japan Society of Applied Physics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-ef1c60bc84f029212a4a51668d3605ba775f7113e4b4a7ed5ec38de35b409583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.35848/1347-4065/ad2c66/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,777,781,27905,27906,53827,53874</link.rule.ids></links><search><creatorcontrib>Ogawa, Narumi</creatorcontrib><creatorcontrib>Ito, Yoshiki</creatorcontrib><creatorcontrib>Watanabe, Shunya</creatorcontrib><creatorcontrib>Araki, Shinnnosuke</creatorcontrib><creatorcontrib>Yoshida, Naoya</creatorcontrib><creatorcontrib>Konishi, Kota</creatorcontrib><creatorcontrib>Noguchi, Ayako</creatorcontrib><creatorcontrib>Miyamoto, Yoshitaka</creatorcontrib><creatorcontrib>Omata, Daiki</creatorcontrib><creatorcontrib>Suzuki, Ryo</creatorcontrib><creatorcontrib>Masuda, Kohji</creatorcontrib><title>Investigation of damage in vascular endothelial cells caused by lipid bubbles under ultrasound irradiation to verify the protective effect on cells</title><title>Japanese Journal of Applied Physics</title><addtitle>Jpn. J. Appl. Phys</addtitle><description>We investigated the viability of vascular endothelial cells engrafted on the basement membrane of a flow channel to verify the protective effect from cell damage under ultrasound exposure with a frequency of 3 MHz and a maximum sound pressure of 400 kPa-pp. We used two types of lipid bubbles (LBs), namely LBs (+) attached to the cells and LBs (–) not attached to the cells. We confirmed that the engrafted cells on the basement remained after ultrasound exposure and were resistant to flow. We found significant cell damage using LBs (–) regardless of the flow condition, whereas cell damage was not observed with LBs (+). A difference in irradiation direction of ultrasound was not detected. By making use of the adhesion of LBs (+) on the cells, since there was a significant increase in cell survival rate, we prove the potential for the adhesion of LBs (+) to protect cells from cell damage.</description><subject>Adhesion</subject><subject>Basements</subject><subject>Bubbles</subject><subject>Endothelial cells</subject><subject>Flow resistance</subject><subject>Lipids</subject><subject>Radiation damage</subject><subject>Sound pressure</subject><subject>Ultrasonic imaging</subject><issn>0021-4922</issn><issn>1347-4065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEtq3TAUhkVpIbdpF5CZoJNM3OhtexhCH4FAAslcyNJRqotiuZJ94e4jC8hasrLqxqWZlIzOg-_8Eh9CJ5R85bIT3Rnlom0EUfLMOGaVeoc2_1bv0YYQRhvRM3aEPpayraOSgm7Q4-W4gzKHezOHNOLksTMP5h5wGPHOFLtEkzGMLs2_IAYTsYUYC7ZmKeDwsH9-imEKtVuGIULBy-gg4yXO2ZRUBxxyNi6s6XPCO8jB73FNw1NOM9g57ACD97XDFXmJ_4Q-eBMLfP5bj9Hd9293Fz-bq-sflxfnV41lvZob8NQqMthOeMJ6RpkRRlKlOscVkYNpW-lbSjmIQZgWnATLOwdcDoL0suPH6MsaW3_ye6kW9DYteawvata3XIjq7EDRlbI5lZLB6ymHB5P3mhL94l4fROuDaL26rzfNehPS9Br6Fn_6H367NZNWXAtNxO0Nk3pynv8BmiqXVw</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Ogawa, Narumi</creator><creator>Ito, Yoshiki</creator><creator>Watanabe, Shunya</creator><creator>Araki, Shinnnosuke</creator><creator>Yoshida, Naoya</creator><creator>Konishi, Kota</creator><creator>Noguchi, Ayako</creator><creator>Miyamoto, Yoshitaka</creator><creator>Omata, Daiki</creator><creator>Suzuki, Ryo</creator><creator>Masuda, Kohji</creator><general>IOP Publishing</general><general>Japanese Journal of Applied Physics</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20240401</creationdate><title>Investigation of damage in vascular endothelial cells caused by lipid bubbles under ultrasound irradiation to verify the protective effect on cells</title><author>Ogawa, Narumi ; Ito, Yoshiki ; Watanabe, Shunya ; Araki, Shinnnosuke ; Yoshida, Naoya ; Konishi, Kota ; Noguchi, Ayako ; Miyamoto, Yoshitaka ; Omata, Daiki ; Suzuki, Ryo ; Masuda, Kohji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-ef1c60bc84f029212a4a51668d3605ba775f7113e4b4a7ed5ec38de35b409583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adhesion</topic><topic>Basements</topic><topic>Bubbles</topic><topic>Endothelial cells</topic><topic>Flow resistance</topic><topic>Lipids</topic><topic>Radiation damage</topic><topic>Sound pressure</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogawa, Narumi</creatorcontrib><creatorcontrib>Ito, Yoshiki</creatorcontrib><creatorcontrib>Watanabe, Shunya</creatorcontrib><creatorcontrib>Araki, Shinnnosuke</creatorcontrib><creatorcontrib>Yoshida, Naoya</creatorcontrib><creatorcontrib>Konishi, Kota</creatorcontrib><creatorcontrib>Noguchi, Ayako</creatorcontrib><creatorcontrib>Miyamoto, Yoshitaka</creatorcontrib><creatorcontrib>Omata, Daiki</creatorcontrib><creatorcontrib>Suzuki, Ryo</creatorcontrib><creatorcontrib>Masuda, Kohji</creatorcontrib><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Japanese Journal of Applied Physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogawa, Narumi</au><au>Ito, Yoshiki</au><au>Watanabe, Shunya</au><au>Araki, Shinnnosuke</au><au>Yoshida, Naoya</au><au>Konishi, Kota</au><au>Noguchi, Ayako</au><au>Miyamoto, Yoshitaka</au><au>Omata, Daiki</au><au>Suzuki, Ryo</au><au>Masuda, Kohji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of damage in vascular endothelial cells caused by lipid bubbles under ultrasound irradiation to verify the protective effect on cells</atitle><jtitle>Japanese Journal of Applied Physics</jtitle><addtitle>Jpn. J. Appl. Phys</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>63</volume><issue>4</issue><spage>4</spage><pages>4-</pages><issn>0021-4922</issn><eissn>1347-4065</eissn><coden>JJAPB6</coden><abstract>We investigated the viability of vascular endothelial cells engrafted on the basement membrane of a flow channel to verify the protective effect from cell damage under ultrasound exposure with a frequency of 3 MHz and a maximum sound pressure of 400 kPa-pp. We used two types of lipid bubbles (LBs), namely LBs (+) attached to the cells and LBs (–) not attached to the cells. We confirmed that the engrafted cells on the basement remained after ultrasound exposure and were resistant to flow. We found significant cell damage using LBs (–) regardless of the flow condition, whereas cell damage was not observed with LBs (+). A difference in irradiation direction of ultrasound was not detected. By making use of the adhesion of LBs (+) on the cells, since there was a significant increase in cell survival rate, we prove the potential for the adhesion of LBs (+) to protect cells from cell damage.</abstract><cop>Tokyo</cop><pub>IOP Publishing</pub><doi>10.35848/1347-4065/ad2c66</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0021-4922 |
| ispartof | Japanese Journal of Applied Physics, 2024-04, Vol.63 (4), p.4 |
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| language | eng |
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| source | IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Adhesion Basements Bubbles Endothelial cells Flow resistance Lipids Radiation damage Sound pressure Ultrasonic imaging |
| title | Investigation of damage in vascular endothelial cells caused by lipid bubbles under ultrasound irradiation to verify the protective effect on cells |
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