Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure

The different effects of deoxynivalenol (DON) on intestinal barrier and stem cells by its route of exposure remain less known. We explored the toxic effects of DON on intestinal barrier functions and stem cells after DON microinjection (luminal exposure) or addition to a culture medium (basolateral...

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Veröffentlicht in:	Toxins 2020-09, Vol.12 (10), p.610, Article 610
Hauptverfasser:	Hanyu, Hikaru, Yokoi, Yuki, Nakamura, Kiminori, Ayabe, Tokiyoshi, Tanaka, Keisuke, Uno, Kinuko, Miyajima, Katsuhiro, Saito, Yuki, Iwatsuki, Ken, Shimizu, Makoto, Tadaishi, Miki, Kobayashi-Hattori, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	basolateral exposure Cell culture Cell growth Deoxynivalenol Dextran Dextrans E-cadherin enteroids Exposure Fluorescein Fluorescence Food Science & Technology G protein-coupled receptors Gene expression Gene sequencing Immunofluorescence intestinal barrier intestinal stem cells Intestine Kinases Leucine Life Sciences & Biomedicine luminal exposure Microinjection Mycotoxins Organoids Proteins Science & Technology Sequence analysis Small intestine Stem cell transplantation Stem cells Toxicology Transgenic mice Zonula occludens-1 protein
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