Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution
The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for s...
Gespeichert in:
| Veröffentlicht in: | Processes 2021-03, Vol.9 (3), p.457, Article 457 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 457 |
| container_title | Processes |
| container_volume | 9 |
| creator | Sarkis, Miriam Bernardi, Andrea Shah, Nilay Papathanasiou, Maria M. |
| description | The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations. |
| doi_str_mv | 10.3390/pr9030457 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3390_pr9030457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2497910990</sourcerecordid><originalsourceid>FETCH-LOGICAL-c292t-19c65ca497eb12376f4cfcbf54d1ef06ec546e7cbf145b3da6cebe865d5eccd93</originalsourceid><addsrcrecordid>eNqNkEtLAzEUhYMoWGoX_oMBVyLVZPKYZinjEyp1oW6HTOamTZlmxiSD-O_NUCkuzSbh5JxzuR9C5wRfUyrxTe8lppjx4ghN8jwv5rIgxfGf9ymahbDF6UhCF1xM0Mf9DvzaunVWblTbgltDyJRrslXfdz4OzkabFOuy143yO6VhiFarNntRbjBKx8GP4TFxZ0P0tk7_nTtDJ0a1AWa_9xS9P9y_lU_z5erxubxdznUu8zgnUguuFZMF1CSnhTBMG10bzhoCBgvQnAkokkIYr2mjhIYaFoI3HLRuJJ2ii31v77vPAUKstt3gXRpZ5alVEiwTkim63Lu070LwYKre253y3xXB1UiuOpBL3sXe-wV1Z4K24DQc_ImcoCxVsxEiKW1U47plN7iYolf_j9Ifd8WDNQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2497910990</pqid></control><display><type>article</type><title>Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Sarkis, Miriam ; Bernardi, Andrea ; Shah, Nilay ; Papathanasiou, Maria M.</creator><creatorcontrib>Sarkis, Miriam ; Bernardi, Andrea ; Shah, Nilay ; Papathanasiou, Maria M.</creatorcontrib><description>The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations.</description><identifier>ISSN: 2227-9717</identifier><identifier>EISSN: 2227-9717</identifier><identifier>DOI: 10.3390/pr9030457</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Agile manufacturing ; Biological products ; Decision making ; Design ; Engineering ; Engineering, Chemical ; Manufacturers ; Manufacturing ; Mathematical models ; Pharmaceutical industry ; Pharmaceuticals ; Product quality ; Science & Technology ; Supply chains ; Systems engineering ; Technology ; Vaccines</subject><ispartof>Processes, 2021-03, Vol.9 (3), p.457, Article 457</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>22</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000634249400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c292t-19c65ca497eb12376f4cfcbf54d1ef06ec546e7cbf145b3da6cebe865d5eccd93</citedby><cites>FETCH-LOGICAL-c292t-19c65ca497eb12376f4cfcbf54d1ef06ec546e7cbf145b3da6cebe865d5eccd93</cites><orcidid>0000-0002-8102-2759 ; 0000-0002-8575-8544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930,39263</link.rule.ids></links><search><creatorcontrib>Sarkis, Miriam</creatorcontrib><creatorcontrib>Bernardi, Andrea</creatorcontrib><creatorcontrib>Shah, Nilay</creatorcontrib><creatorcontrib>Papathanasiou, Maria M.</creatorcontrib><title>Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution</title><title>Processes</title><addtitle>PROCESSES</addtitle><description>The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations.</description><subject>Agile manufacturing</subject><subject>Biological products</subject><subject>Decision making</subject><subject>Design</subject><subject>Engineering</subject><subject>Engineering, Chemical</subject><subject>Manufacturers</subject><subject>Manufacturing</subject><subject>Mathematical models</subject><subject>Pharmaceutical industry</subject><subject>Pharmaceuticals</subject><subject>Product quality</subject><subject>Science & Technology</subject><subject>Supply chains</subject><subject>Systems engineering</subject><subject>Technology</subject><subject>Vaccines</subject><issn>2227-9717</issn><issn>2227-9717</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkEtLAzEUhYMoWGoX_oMBVyLVZPKYZinjEyp1oW6HTOamTZlmxiSD-O_NUCkuzSbh5JxzuR9C5wRfUyrxTe8lppjx4ghN8jwv5rIgxfGf9ymahbDF6UhCF1xM0Mf9DvzaunVWblTbgltDyJRrslXfdz4OzkabFOuy143yO6VhiFarNntRbjBKx8GP4TFxZ0P0tk7_nTtDJ0a1AWa_9xS9P9y_lU_z5erxubxdznUu8zgnUguuFZMF1CSnhTBMG10bzhoCBgvQnAkokkIYr2mjhIYaFoI3HLRuJJ2ii31v77vPAUKstt3gXRpZ5alVEiwTkim63Lu070LwYKre253y3xXB1UiuOpBL3sXe-wV1Z4K24DQc_ImcoCxVsxEiKW1U47plN7iYolf_j9Ifd8WDNQ</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Sarkis, Miriam</creator><creator>Bernardi, Andrea</creator><creator>Shah, Nilay</creator><creator>Papathanasiou, Maria M.</creator><general>Mdpi</general><general>MDPI AG</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>LK8</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-8102-2759</orcidid><orcidid>https://orcid.org/0000-0002-8575-8544</orcidid></search><sort><creationdate>20210301</creationdate><title>Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution</title><author>Sarkis, Miriam ; Bernardi, Andrea ; Shah, Nilay ; Papathanasiou, Maria M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-19c65ca497eb12376f4cfcbf54d1ef06ec546e7cbf145b3da6cebe865d5eccd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Agile manufacturing</topic><topic>Biological products</topic><topic>Decision making</topic><topic>Design</topic><topic>Engineering</topic><topic>Engineering, Chemical</topic><topic>Manufacturers</topic><topic>Manufacturing</topic><topic>Mathematical models</topic><topic>Pharmaceutical industry</topic><topic>Pharmaceuticals</topic><topic>Product quality</topic><topic>Science & Technology</topic><topic>Supply chains</topic><topic>Systems engineering</topic><topic>Technology</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarkis, Miriam</creatorcontrib><creatorcontrib>Bernardi, Andrea</creatorcontrib><creatorcontrib>Shah, Nilay</creatorcontrib><creatorcontrib>Papathanasiou, Maria M.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Processes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarkis, Miriam</au><au>Bernardi, Andrea</au><au>Shah, Nilay</au><au>Papathanasiou, Maria M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution</atitle><jtitle>Processes</jtitle><stitle>PROCESSES</stitle><date>2021-03-01</date><risdate>2021</risdate><volume>9</volume><issue>3</issue><spage>457</spage><pages>457-</pages><artnum>457</artnum><issn>2227-9717</issn><eissn>2227-9717</eissn><abstract>The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations.</abstract><cop>BASEL</cop><pub>Mdpi</pub><doi>10.3390/pr9030457</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-8102-2759</orcidid><orcidid>https://orcid.org/0000-0002-8575-8544</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2227-9717 |
| ispartof | Processes, 2021-03, Vol.9 (3), p.457, Article 457 |
| issn | 2227-9717 2227-9717 |
| language | eng |
| recordid | cdi_crossref_primary_10_3390_pr9030457 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Agile manufacturing Biological products Decision making Design Engineering Engineering, Chemical Manufacturers Manufacturing Mathematical models Pharmaceutical industry Pharmaceuticals Product quality Science & Technology Supply chains Systems engineering Technology Vaccines |
| title | Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T02%3A19%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Emerging%20Challenges%20and%20Opportunities%20in%20Pharmaceutical%20Manufacturing%20and%20Distribution&rft.jtitle=Processes&rft.au=Sarkis,%20Miriam&rft.date=2021-03-01&rft.volume=9&rft.issue=3&rft.spage=457&rft.pages=457-&rft.artnum=457&rft.issn=2227-9717&rft.eissn=2227-9717&rft_id=info:doi/10.3390/pr9030457&rft_dat=%3Cproquest_cross%3E2497910990%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2497910990&rft_id=info:pmid/&rfr_iscdi=true |