The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention
The present study aims to examine the effects of three different high-fat diet (HFD) on mice gut microbiota in order to analyse whether they create the microenvironmental conditions that either promote or prevent colorectal cancer (CRC). We evaluated colonic mucosa-associated microbiota in CD1 mice...
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| Veröffentlicht in: | Nutrients 2020-06, Vol.12 (6), p.1705, Article 1705 |
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| description | The present study aims to examine the effects of three different high-fat diet (HFD) on mice gut microbiota in order to analyse whether they create the microenvironmental conditions that either promote or prevent colorectal cancer (CRC). We evaluated colonic mucosa-associated microbiota in CD1 mice fed with HFD, based on 60% kcal from fat-containing coconut, sunflower or extra-virgin olive oil as the only source of fat. The main findings were as follows: (a) All HFD produced a decrease in the richness and diversity of the intestinal microbiota that was independent of mouse weight, (b) HFD switchedLactobacillustoLactococcus. In general, the results showed that both sunflower- and coconut-HFD generated a pro-inflammatory intestinal microenvironment. In brief, coconut-HFD decreasedAkkermansiaand increasedStaphylococcus, Prevotella and Bacteroidesspp. abundance. Sunflower-HFD reducedAkkermansiaandBifidobacterium, while enhancingSphingomonasandNeisseriaspp. abundance. In contrast, EVOO-HFD produced an anti-inflammatory microenvironment characterised by a decreasedEnterococcus,Staphylococcus,NeisseriaandPseudomonasspp. abundance. At the same time, it increased the Firmicutes/Bacteroidetes ratio and maintained theAkkermansiapopulation. To conclude, EVOO-HFD produced changes in the gut microbiota that are associated with the prevention of CRC, while coconut and sunflower-HFD caused changes associated with an increased risk of CRC. |
| doi_str_mv | 10.3390/nu12061705 |
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We evaluated colonic mucosa-associated microbiota in CD1 mice fed with HFD, based on 60% kcal from fat-containing coconut, sunflower or extra-virgin olive oil as the only source of fat. The main findings were as follows: (a) All HFD produced a decrease in the richness and diversity of the intestinal microbiota that was independent of mouse weight, (b) HFD switchedLactobacillustoLactococcus. In general, the results showed that both sunflower- and coconut-HFD generated a pro-inflammatory intestinal microenvironment. In brief, coconut-HFD decreasedAkkermansiaand increasedStaphylococcus, Prevotella and Bacteroidesspp. abundance. Sunflower-HFD reducedAkkermansiaandBifidobacterium, while enhancingSphingomonasandNeisseriaspp. abundance. In contrast, EVOO-HFD produced an anti-inflammatory microenvironment characterised by a decreasedEnterococcus,Staphylococcus,NeisseriaandPseudomonasspp. abundance. At the same time, it increased the Firmicutes/Bacteroidetes ratio and maintained theAkkermansiapopulation. To conclude, EVOO-HFD produced changes in the gut microbiota that are associated with the prevention of CRC, while coconut and sunflower-HFD caused changes associated with an increased risk of CRC.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12061705</identifier><identifier>PMID: 32517306</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Abundance ; Akkermansia ; Animals ; Bacteria ; Bacteroidetes ; coconut oil ; Coconut Oil - adverse effects ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - etiology ; Colorectal Neoplasms - microbiology ; Colorectal Neoplasms - prevention & control ; Deoxyribonucleic acid ; Diet ; Diet, High-Fat - adverse effects ; Digestive system ; DNA ; Dysbacteriosis ; Dysbiosis - etiology ; Enterococcus ; Firmicutes ; Gastrointestinal Microbiome ; gut microbiome ; Helianthus ; High fat diet ; Inflammation ; Intestinal microflora ; Intestinal Mucosa - microbiology ; Intestine ; Laboratory animals ; Life Sciences & Biomedicine ; Mice ; Microbiota ; Mucosa ; Neisseria ; Nutrition & Dietetics ; Oils & fats ; Olive Oil ; Prevention ; Risk ; Science & Technology ; Staphylococcus ; sunflower oil ; Sunflower Oil - adverse effects ; Sunflowers ; Tumor Microenvironment ; Values ; Vegetable oils</subject><ispartof>Nutrients, 2020-06, Vol.12 (6), p.1705, Article 1705</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>25</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000549276200001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c472t-32188344e883cd0a4c793ce905db4452397a35cbbbb3a2b127a08d7803a4bf263</citedby><cites>FETCH-LOGICAL-c472t-32188344e883cd0a4c793ce905db4452397a35cbbbb3a2b127a08d7803a4bf263</cites><orcidid>0000-0003-2996-9301 ; 0000-0002-4531-3188 ; 0000-0003-2997-8515</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352482/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352482/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32517306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez-Garcia, Carmen</creatorcontrib><creatorcontrib>Sanchez-Quesada, Cristina</creatorcontrib><creatorcontrib>Algarra, Ignacio</creatorcontrib><creatorcontrib>Gaforio, Jose J.</creatorcontrib><title>The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention</title><title>Nutrients</title><addtitle>NUTRIENTS</addtitle><addtitle>Nutrients</addtitle><description>The present study aims to examine the effects of three different high-fat diet (HFD) on mice gut microbiota in order to analyse whether they create the microenvironmental conditions that either promote or prevent colorectal cancer (CRC). We evaluated colonic mucosa-associated microbiota in CD1 mice fed with HFD, based on 60% kcal from fat-containing coconut, sunflower or extra-virgin olive oil as the only source of fat. The main findings were as follows: (a) All HFD produced a decrease in the richness and diversity of the intestinal microbiota that was independent of mouse weight, (b) HFD switchedLactobacillustoLactococcus. In general, the results showed that both sunflower- and coconut-HFD generated a pro-inflammatory intestinal microenvironment. In brief, coconut-HFD decreasedAkkermansiaand increasedStaphylococcus, Prevotella and Bacteroidesspp. abundance. Sunflower-HFD reducedAkkermansiaandBifidobacterium, while enhancingSphingomonasandNeisseriaspp. abundance. In contrast, EVOO-HFD produced an anti-inflammatory microenvironment characterised by a decreasedEnterococcus,Staphylococcus,NeisseriaandPseudomonasspp. abundance. At the same time, it increased the Firmicutes/Bacteroidetes ratio and maintained theAkkermansiapopulation. To conclude, EVOO-HFD produced changes in the gut microbiota that are associated with the prevention of CRC, while coconut and sunflower-HFD caused changes associated with an increased risk of CRC.</description><subject>Abundance</subject><subject>Akkermansia</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Bacteroidetes</subject><subject>coconut oil</subject><subject>Coconut Oil - adverse effects</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Colorectal Neoplasms - microbiology</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Digestive system</subject><subject>DNA</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis - etiology</subject><subject>Enterococcus</subject><subject>Firmicutes</subject><subject>Gastrointestinal Microbiome</subject><subject>gut microbiome</subject><subject>Helianthus</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestine</subject><subject>Laboratory animals</subject><subject>Life Sciences & Biomedicine</subject><subject>Mice</subject><subject>Microbiota</subject><subject>Mucosa</subject><subject>Neisseria</subject><subject>Nutrition & Dietetics</subject><subject>Oils & fats</subject><subject>Olive Oil</subject><subject>Prevention</subject><subject>Risk</subject><subject>Science & Technology</subject><subject>Staphylococcus</subject><subject>sunflower oil</subject><subject>Sunflower Oil - adverse effects</subject><subject>Sunflowers</subject><subject>Tumor Microenvironment</subject><subject>Values</subject><subject>Vegetable oils</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEolXphR-ALHEDBfyV2LkgQdrSSisth8LVmtjOrpc0Lrazbf89Dlu27a1zsC378Tsev1MUbwn-xFiDP48TobgmAlcvikOKBS3rmrOXj9YHxXGMGzyHwKJmr4sDRisiGK4PC3e5tujcrdblGSR04mxC3yBag_yITm9TgPKXCys3ouXgthYt3YBamKKN6OQuds5HF9HCjb_zjeRR6wcfrE4wU6O2Af0IdmvH5Pz4pnjVwxDt8f18VPw8O71sz8vF8vtF-3VRai5oKhklUjLObR61wcC1aJi2Da5Mx3lFWSOAVbrLwYB2hArA0giJGfCupzU7Ki52usbDRl0HdwXhTnlw6t-GDysFITk9WIWJAKO5NH0veSctNB0Yk79M5hwYqqz1Zad1PXVX1uhcSYDhiejTk9Gt1cpvlWAV5ZJmgff3AsH_mWxMauOnMOb6FeWENBWRYk7zYUfp4GMMtt9nIFjNLqsHlzP87vGb9uh_TzPwcQfc2M73UTubndhjuQsq3lBR07khSKbl8-nWJZi9bP00JvYXxrLCRQ</recordid><startdate>20200607</startdate><enddate>20200607</enddate><creator>Rodriguez-Garcia, Carmen</creator><creator>Sanchez-Quesada, Cristina</creator><creator>Algarra, Ignacio</creator><creator>Gaforio, Jose J.</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2996-9301</orcidid><orcidid>https://orcid.org/0000-0002-4531-3188</orcidid><orcidid>https://orcid.org/0000-0003-2997-8515</orcidid></search><sort><creationdate>20200607</creationdate><title>The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention</title><author>Rodriguez-Garcia, Carmen ; Sanchez-Quesada, Cristina ; Algarra, Ignacio ; Gaforio, Jose J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-32188344e883cd0a4c793ce905db4452397a35cbbbb3a2b127a08d7803a4bf263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abundance</topic><topic>Akkermansia</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Bacteroidetes</topic><topic>coconut oil</topic><topic>Coconut Oil - adverse effects</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - etiology</topic><topic>Colorectal Neoplasms - microbiology</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Deoxyribonucleic acid</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Digestive system</topic><topic>DNA</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis - etiology</topic><topic>Enterococcus</topic><topic>Firmicutes</topic><topic>Gastrointestinal Microbiome</topic><topic>gut microbiome</topic><topic>Helianthus</topic><topic>High fat diet</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestine</topic><topic>Laboratory animals</topic><topic>Life Sciences & Biomedicine</topic><topic>Mice</topic><topic>Microbiota</topic><topic>Mucosa</topic><topic>Neisseria</topic><topic>Nutrition & Dietetics</topic><topic>Oils & fats</topic><topic>Olive Oil</topic><topic>Prevention</topic><topic>Risk</topic><topic>Science & Technology</topic><topic>Staphylococcus</topic><topic>sunflower oil</topic><topic>Sunflower Oil - adverse effects</topic><topic>Sunflowers</topic><topic>Tumor Microenvironment</topic><topic>Values</topic><topic>Vegetable oils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez-Garcia, Carmen</creatorcontrib><creatorcontrib>Sanchez-Quesada, Cristina</creatorcontrib><creatorcontrib>Algarra, Ignacio</creatorcontrib><creatorcontrib>Gaforio, Jose J.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez-Garcia, Carmen</au><au>Sanchez-Quesada, Cristina</au><au>Algarra, Ignacio</au><au>Gaforio, Jose J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention</atitle><jtitle>Nutrients</jtitle><stitle>NUTRIENTS</stitle><addtitle>Nutrients</addtitle><date>2020-06-07</date><risdate>2020</risdate><volume>12</volume><issue>6</issue><spage>1705</spage><pages>1705-</pages><artnum>1705</artnum><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>The present study aims to examine the effects of three different high-fat diet (HFD) on mice gut microbiota in order to analyse whether they create the microenvironmental conditions that either promote or prevent colorectal cancer (CRC). We evaluated colonic mucosa-associated microbiota in CD1 mice fed with HFD, based on 60% kcal from fat-containing coconut, sunflower or extra-virgin olive oil as the only source of fat. The main findings were as follows: (a) All HFD produced a decrease in the richness and diversity of the intestinal microbiota that was independent of mouse weight, (b) HFD switchedLactobacillustoLactococcus. In general, the results showed that both sunflower- and coconut-HFD generated a pro-inflammatory intestinal microenvironment. In brief, coconut-HFD decreasedAkkermansiaand increasedStaphylococcus, Prevotella and Bacteroidesspp. abundance. Sunflower-HFD reducedAkkermansiaandBifidobacterium, while enhancingSphingomonasandNeisseriaspp. abundance. In contrast, EVOO-HFD produced an anti-inflammatory microenvironment characterised by a decreasedEnterococcus,Staphylococcus,NeisseriaandPseudomonasspp. abundance. At the same time, it increased the Firmicutes/Bacteroidetes ratio and maintained theAkkermansiapopulation. To conclude, EVOO-HFD produced changes in the gut microbiota that are associated with the prevention of CRC, while coconut and sunflower-HFD caused changes associated with an increased risk of CRC.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>32517306</pmid><doi>10.3390/nu12061705</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-2996-9301</orcidid><orcidid>https://orcid.org/0000-0002-4531-3188</orcidid><orcidid>https://orcid.org/0000-0003-2997-8515</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abundance Akkermansia Animals Bacteria Bacteroidetes coconut oil Coconut Oil - adverse effects Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - etiology Colorectal Neoplasms - microbiology Colorectal Neoplasms - prevention & control Deoxyribonucleic acid Diet Diet, High-Fat - adverse effects Digestive system DNA Dysbacteriosis Dysbiosis - etiology Enterococcus Firmicutes Gastrointestinal Microbiome gut microbiome Helianthus High fat diet Inflammation Intestinal microflora Intestinal Mucosa - microbiology Intestine Laboratory animals Life Sciences & Biomedicine Mice Microbiota Mucosa Neisseria Nutrition & Dietetics Oils & fats Olive Oil Prevention Risk Science & Technology Staphylococcus sunflower oil Sunflower Oil - adverse effects Sunflowers Tumor Microenvironment Values Vegetable oils |
| title | The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention |
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