Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies
Formulation of promising anticancer herbal drug curcumin as a nanoscale-sized curcumin (nanocurcumin) improved its delivery to cells and organisms both in vitro and in vivo. We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endo...
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| Veröffentlicht in: | Nanomaterials (Basel, Switzerland) Switzerland), 2021-08, Vol.11 (9), p.2234, Article 2234 |
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| creator | Lakshmanan, Anbharasi Akasov, Roman A. Sholina, Natalya V. Demina, Polina A. Generalova, Alla N. Gangadharan, Ajithkumar Sardar, Dhiraj K. Lankamsetty, Krishna Bharat Khochenkov, Dmitry A. Khaydukov, Evgeny V. Gudkov, Sergey V. Jayaraman, Manonmani Jayaraman, Senthilselvan |
| description | Formulation of promising anticancer herbal drug curcumin as a nanoscale-sized curcumin (nanocurcumin) improved its delivery to cells and organisms both in vitro and in vivo. We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endow visualisation in the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) and NaYF4:Yb,Tm (UCNP2) nanoparticles were synthesised by reverse microemulsion method and then functionalized it with PLGA to form UCNP-PLGA nanocarrier followed up by loading with the solvent-antisolvent process synthesized herbal nanocurcumin. The UCNP samples were extensively characterised with XRD, Raman, FTIR, DSC, TGA, UV-VIS-NIR spectrophotometer, Upconversion spectrofluorometer, HRSEM, EDAX and Zeta Potential analyses. UCNP1-PLGA-nanocurcumin exhibited emission at 520, 540, 660 nm and UCNP2-PLGA-nanocurmin showed emission at 480 and 800 nm spectral bands. UCNP-PLGA-nanocurcumin incubated with rat glioblastoma cells demonstrated moderate cytotoxicity, 60-80% cell viability at 0.12-0.02 mg/mL marginally suitable for therapeutic applications. The cytotoxicity of UCNPs evaluated in tumour spheroids models confirmed UCNP-PLGA-nanocurcumin therapeutic potential. As-synthesised curcumin-loaded nanocomplexes were administered in tumour-bearing laboratory animals (Lewis lung cancer model) and showed adequate contrast to enable in vivo and ex vivo study of UCNP-PLGA-nanocurcumin bio distribution in organs, with dominant distribution in the liver and lungs. Our studies demonstrate promise of nanocurcumin-loaded upconversion nanoparticles for theranostics applications. |
| doi_str_mv | 10.3390/nano11092234 |
| format | Article |
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We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endow visualisation in the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) and NaYF4:Yb,Tm (UCNP2) nanoparticles were synthesised by reverse microemulsion method and then functionalized it with PLGA to form UCNP-PLGA nanocarrier followed up by loading with the solvent-antisolvent process synthesized herbal nanocurcumin. The UCNP samples were extensively characterised with XRD, Raman, FTIR, DSC, TGA, UV-VIS-NIR spectrophotometer, Upconversion spectrofluorometer, HRSEM, EDAX and Zeta Potential analyses. UCNP1-PLGA-nanocurcumin exhibited emission at 520, 540, 660 nm and UCNP2-PLGA-nanocurmin showed emission at 480 and 800 nm spectral bands. UCNP-PLGA-nanocurcumin incubated with rat glioblastoma cells demonstrated moderate cytotoxicity, 60-80% cell viability at 0.12-0.02 mg/mL marginally suitable for therapeutic applications. The cytotoxicity of UCNPs evaluated in tumour spheroids models confirmed UCNP-PLGA-nanocurcumin therapeutic potential. As-synthesised curcumin-loaded nanocomplexes were administered in tumour-bearing laboratory animals (Lewis lung cancer model) and showed adequate contrast to enable in vivo and ex vivo study of UCNP-PLGA-nanocurcumin bio distribution in organs, with dominant distribution in the liver and lungs. Our studies demonstrate promise of nanocurcumin-loaded upconversion nanoparticles for theranostics applications.</description><identifier>ISSN: 2079-4991</identifier><identifier>EISSN: 2079-4991</identifier><identifier>DOI: 10.3390/nano11092234</identifier><identifier>PMID: 34578550</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Bioavailability ; Biocompatibility ; Brain cancer ; Cancer therapies ; Cell viability ; Chemistry ; Chemistry, Multidisciplinary ; Curcumin ; Cytotoxicity ; Emission analysis ; Emissions ; Erbium ; Fluorides ; Glioblastoma ; Glioblastoma cells ; Glycolic acid ; herbal drugs ; Herbal medicine ; In vivo methods and tests ; intravital imaging ; Laboratories ; Laboratory animals ; Lung cancer ; Materials Science ; Materials Science, Multidisciplinary ; Metabolism ; Microemulsions ; Morphology ; nanocurcumin ; Nanomaterials ; Nanoparticles ; Nanoscience & Nanotechnology ; Nitrates ; Nuclear physics ; Organs ; Physical Sciences ; Physicochemical properties ; Physics ; Physics, Applied ; Polylactide-co-glycolide ; Polymers ; Precision medicine ; Quantum dots ; Science & Technology ; Science & Technology - Other Topics ; Sodium compounds ; Software ; Solvents ; Spectral bands ; Spheroids ; Technology ; theranostics ; Therapeutic applications ; Toxicity ; Tumors ; Upconversion ; upconversion nanoparticles ; Ytterbium ; Zeta potential</subject><ispartof>Nanomaterials (Basel, Switzerland), 2021-08, Vol.11 (9), p.2234, Article 2234</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endow visualisation in the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) and NaYF4:Yb,Tm (UCNP2) nanoparticles were synthesised by reverse microemulsion method and then functionalized it with PLGA to form UCNP-PLGA nanocarrier followed up by loading with the solvent-antisolvent process synthesized herbal nanocurcumin. The UCNP samples were extensively characterised with XRD, Raman, FTIR, DSC, TGA, UV-VIS-NIR spectrophotometer, Upconversion spectrofluorometer, HRSEM, EDAX and Zeta Potential analyses. UCNP1-PLGA-nanocurcumin exhibited emission at 520, 540, 660 nm and UCNP2-PLGA-nanocurmin showed emission at 480 and 800 nm spectral bands. UCNP-PLGA-nanocurcumin incubated with rat glioblastoma cells demonstrated moderate cytotoxicity, 60-80% cell viability at 0.12-0.02 mg/mL marginally suitable for therapeutic applications. The cytotoxicity of UCNPs evaluated in tumour spheroids models confirmed UCNP-PLGA-nanocurcumin therapeutic potential. As-synthesised curcumin-loaded nanocomplexes were administered in tumour-bearing laboratory animals (Lewis lung cancer model) and showed adequate contrast to enable in vivo and ex vivo study of UCNP-PLGA-nanocurcumin bio distribution in organs, with dominant distribution in the liver and lungs. Our studies demonstrate promise of nanocurcumin-loaded upconversion nanoparticles for theranostics applications.</description><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>Brain cancer</subject><subject>Cancer therapies</subject><subject>Cell viability</subject><subject>Chemistry</subject><subject>Chemistry, Multidisciplinary</subject><subject>Curcumin</subject><subject>Cytotoxicity</subject><subject>Emission analysis</subject><subject>Emissions</subject><subject>Erbium</subject><subject>Fluorides</subject><subject>Glioblastoma</subject><subject>Glioblastoma cells</subject><subject>Glycolic acid</subject><subject>herbal drugs</subject><subject>Herbal medicine</subject><subject>In vivo methods and tests</subject><subject>intravital imaging</subject><subject>Laboratories</subject><subject>Laboratory animals</subject><subject>Lung cancer</subject><subject>Materials Science</subject><subject>Materials Science, Multidisciplinary</subject><subject>Metabolism</subject><subject>Microemulsions</subject><subject>Morphology</subject><subject>nanocurcumin</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanoscience & Nanotechnology</subject><subject>Nitrates</subject><subject>Nuclear physics</subject><subject>Organs</subject><subject>Physical Sciences</subject><subject>Physicochemical properties</subject><subject>Physics</subject><subject>Physics, Applied</subject><subject>Polylactide-co-glycolide</subject><subject>Polymers</subject><subject>Precision medicine</subject><subject>Quantum dots</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Sodium compounds</subject><subject>Software</subject><subject>Solvents</subject><subject>Spectral bands</subject><subject>Spheroids</subject><subject>Technology</subject><subject>theranostics</subject><subject>Therapeutic applications</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>Upconversion</subject><subject>upconversion nanoparticles</subject><subject>Ytterbium</subject><subject>Zeta 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Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nanomaterials (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakshmanan, Anbharasi</au><au>Akasov, Roman A.</au><au>Sholina, Natalya V.</au><au>Demina, Polina A.</au><au>Generalova, Alla N.</au><au>Gangadharan, Ajithkumar</au><au>Sardar, Dhiraj K.</au><au>Lankamsetty, Krishna Bharat</au><au>Khochenkov, Dmitry A.</au><au>Khaydukov, Evgeny V.</au><au>Gudkov, Sergey V.</au><au>Jayaraman, Manonmani</au><au>Jayaraman, Senthilselvan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies</atitle><jtitle>Nanomaterials (Basel, Switzerland)</jtitle><stitle>NANOMATERIALS-BASEL</stitle><addtitle>Nanomaterials (Basel)</addtitle><date>2021-08-29</date><risdate>2021</risdate><volume>11</volume><issue>9</issue><spage>2234</spage><pages>2234-</pages><artnum>2234</artnum><issn>2079-4991</issn><eissn>2079-4991</eissn><abstract>Formulation of promising anticancer herbal drug curcumin as a nanoscale-sized curcumin (nanocurcumin) improved its delivery to cells and organisms both in vitro and in vivo. We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endow visualisation in the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) and NaYF4:Yb,Tm (UCNP2) nanoparticles were synthesised by reverse microemulsion method and then functionalized it with PLGA to form UCNP-PLGA nanocarrier followed up by loading with the solvent-antisolvent process synthesized herbal nanocurcumin. The UCNP samples were extensively characterised with XRD, Raman, FTIR, DSC, TGA, UV-VIS-NIR spectrophotometer, Upconversion spectrofluorometer, HRSEM, EDAX and Zeta Potential analyses. UCNP1-PLGA-nanocurcumin exhibited emission at 520, 540, 660 nm and UCNP2-PLGA-nanocurmin showed emission at 480 and 800 nm spectral bands. UCNP-PLGA-nanocurcumin incubated with rat glioblastoma cells demonstrated moderate cytotoxicity, 60-80% cell viability at 0.12-0.02 mg/mL marginally suitable for therapeutic applications. The cytotoxicity of UCNPs evaluated in tumour spheroids models confirmed UCNP-PLGA-nanocurcumin therapeutic potential. As-synthesised curcumin-loaded nanocomplexes were administered in tumour-bearing laboratory animals (Lewis lung cancer model) and showed adequate contrast to enable in vivo and ex vivo study of UCNP-PLGA-nanocurcumin bio distribution in organs, with dominant distribution in the liver and lungs. Our studies demonstrate promise of nanocurcumin-loaded upconversion nanoparticles for theranostics applications.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>34578550</pmid><doi>10.3390/nano11092234</doi><tpages>25</tpages><orcidid>https://orcid.org/0000-0002-8814-6906</orcidid><orcidid>https://orcid.org/0000-0002-3900-2949</orcidid><orcidid>https://orcid.org/0000-0001-9680-1301</orcidid><orcidid>https://orcid.org/0000-0001-9646-1693</orcidid><orcidid>https://orcid.org/0000-0002-5694-3492</orcidid><orcidid>https://orcid.org/0000-0001-6486-8114</orcidid><orcidid>https://orcid.org/0000-0001-6349-2979</orcidid><orcidid>https://orcid.org/0000-0002-8028-0887</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2079-4991 |
| ispartof | Nanomaterials (Basel, Switzerland), 2021-08, Vol.11 (9), p.2234, Article 2234 |
| issn | 2079-4991 2079-4991 |
| language | eng |
| recordid | cdi_crossref_primary_10_3390_nano11092234 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central |
| subjects | Bioavailability Biocompatibility Brain cancer Cancer therapies Cell viability Chemistry Chemistry, Multidisciplinary Curcumin Cytotoxicity Emission analysis Emissions Erbium Fluorides Glioblastoma Glioblastoma cells Glycolic acid herbal drugs Herbal medicine In vivo methods and tests intravital imaging Laboratories Laboratory animals Lung cancer Materials Science Materials Science, Multidisciplinary Metabolism Microemulsions Morphology nanocurcumin Nanomaterials Nanoparticles Nanoscience & Nanotechnology Nitrates Nuclear physics Organs Physical Sciences Physicochemical properties Physics Physics, Applied Polylactide-co-glycolide Polymers Precision medicine Quantum dots Science & Technology Science & Technology - Other Topics Sodium compounds Software Solvents Spectral bands Spheroids Technology theranostics Therapeutic applications Toxicity Tumors Upconversion upconversion nanoparticles Ytterbium Zeta potential |
| title | Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T03%3A24%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nanocurcumin-Loaded%20UCNPs%20for%20Cancer%20Theranostics:%20Physicochemical%20Properties,%20In%20Vitro%20Toxicity,%20and%20In%20Vivo%20Imaging%20Studies&rft.jtitle=Nanomaterials%20(Basel,%20Switzerland)&rft.au=Lakshmanan,%20Anbharasi&rft.date=2021-08-29&rft.volume=11&rft.issue=9&rft.spage=2234&rft.pages=2234-&rft.artnum=2234&rft.issn=2079-4991&rft.eissn=2079-4991&rft_id=info:doi/10.3390/nano11092234&rft_dat=%3Cproquest_cross%3E2576481026%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2576481026&rft_id=info:pmid/34578550&rft_doaj_id=oai_doaj_org_article_55e56183a18f4a1da8df0c4e24e37622&rfr_iscdi=true |