Theragnostic Glycol Chitosan-Conjugated Gold Nanoparticles for Photoacoustic Imaging of Regional Lymph Nodes and Delivering Tumor Antigen to Lymph Nodes

Lymph node mapping is important in cancer immunotherapy because the morphology of lymph nodes is one of the crucial evaluation criteria of immune responses. We developed new theragnostic glycol-chitosan-coated gold nanoparticles (GC-AuNPs), which highlighted lymph nodes in ultrasound-guided photoaco...

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Veröffentlicht in:Nanomaterials (Basel, Switzerland) Switzerland), 2021-06, Vol.11 (7), p.1700
Hauptverfasser: Sun, In-Cheol, Jo, SeongHoon, Dumani, Diego, Yun, Wan Su, Yoon, Hong Yeol, Lim, Dong-Kwon, Ahn, Cheol-Hee, Emelianov, Stanislav, Kim, Kwangmeyung
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container_title Nanomaterials (Basel, Switzerland)
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creator Sun, In-Cheol
Jo, SeongHoon
Dumani, Diego
Yun, Wan Su
Yoon, Hong Yeol
Lim, Dong-Kwon
Ahn, Cheol-Hee
Emelianov, Stanislav
Kim, Kwangmeyung
description Lymph node mapping is important in cancer immunotherapy because the morphology of lymph nodes is one of the crucial evaluation criteria of immune responses. We developed new theragnostic glycol-chitosan-coated gold nanoparticles (GC-AuNPs), which highlighted lymph nodes in ultrasound-guided photoacoustic (US/PA) imaging. Moreover, the ovalbumin epitope was conjugated GC-AuNPs (OVA-GC-AuNPs) for delivering tumor antigen to lymph node resident macrophage. In vitro studies proved the vigorous endocytosis activity of J774A.1 macrophage and consequent strong photoacoustic signals from them. The macrophages also presented a tumor antigen when OVA-GC-AuNPs were used for cellular uptake. After the lingual injection of GC-AuNPs into healthy mice, cervical lymph nodes were visible in a US/PA imaging system with high contrast. Three-dimensional analysis of lymph nodes revealed that the accumulation of GC-AuNPs in the lymph node increased as the post-injection time passed. Histological analysis showed GC-AuNPs or OVA-GC-AuNPs located in subcapsular and medullar sinuses where macrophages are abundant. Our new theragnostic GC-AuNPs present a superior performance in US/PA imaging of lymph nodes without targeting moieties or complex surface modification. Simultaneously, GC-AuNPs were able to deliver tumor antigens to cause macrophages to present the OVA epitope at targeted lymph nodes, which would be valuable for cancer immunotherapy.
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subjects Antigen (tumor-associated)
Antigens
Biopsy
Cancer
Cancer immunotherapy
Chitosan
Contrast agents
Cytotoxicity
Dimensional analysis
Efficiency
Endocytosis
glycol chitosan
Gold
Imaging
Immune response
Immunotherapy
Injection
lymph node
Lymph nodes
Lymphatic system
Macrophages
Magnetic resonance imaging
Mathematical analysis
Medical research
Morphology
Nanoparticles
Ovalbumin
Peptides
photoacoustic imaging
Sinuses
theragnostic gold nanoparticle
Three dimensional analysis
tumor antigen delivery
Tumors
Ultrasonic imaging
title Theragnostic Glycol Chitosan-Conjugated Gold Nanoparticles for Photoacoustic Imaging of Regional Lymph Nodes and Delivering Tumor Antigen to Lymph Nodes
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