Magnetic Solid-Phase Extraction Based on Magnetic Sulfonated Reduced Graphene Oxide for HPLC-MS/MS Analysis of Illegal Basic Dyes in Foods
In this study, a magnetic solid-phase extraction (MSPE) method coupled with High-Performance Liquid Chromatography Mass Spectrometry (HPLC-MS/MS) for the determination of illegal basic dyes in food samples was developed and validated. This method was based on Magnetic sulfonated reduced graphene oxi...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2021-12, Vol.26 (24), p.7427 |
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| creator | Cui, Shibo Mao, Xinwu Zhang, Haijing Zeng, Haowei Lin, Zihao Zhang, Xuewu Qi, Ping |
| description | In this study, a magnetic solid-phase extraction (MSPE) method coupled with High-Performance Liquid Chromatography Mass Spectrometry (HPLC-MS/MS) for the determination of illegal basic dyes in food samples was developed and validated. This method was based on Magnetic sulfonated reduced graphene oxide (M-S-RGO), which was sensitive and selective to analytes with structure of multiaromatic rings and negatively charged ions. Several factors affecting MSPE efficiency such as pH and adsorption time were optimized. Under the optimum conditions, the calibration curves exhibited good linearity, ranging from 5 to 60 µg/g with correlation coefficients >0.9950. The limits of detection of 16 basic dyes were in the range of 0.01-0.2 µg/L. The recoveries ranged from 70% to 110% with RSD% < 10%. The results indicate that M-S-RGO is an efficient and selective adsorbent for the extraction and cleanup of basic dyes. Due to the MSPE procedures, matrix effect and interference were eliminated in the analysis of HPLC-MS/MS without the matrix-matched standards. Thus, validation data showed that the proposed MSPE-HPLC-MS/MS method was rapid, efficient, selective, and sensitive for the determination of illegal basic dyes in foods. |
| doi_str_mv | 10.3390/molecules26247427 |
| format | Article |
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This method was based on Magnetic sulfonated reduced graphene oxide (M-S-RGO), which was sensitive and selective to analytes with structure of multiaromatic rings and negatively charged ions. Several factors affecting MSPE efficiency such as pH and adsorption time were optimized. Under the optimum conditions, the calibration curves exhibited good linearity, ranging from 5 to 60 µg/g with correlation coefficients >0.9950. The limits of detection of 16 basic dyes were in the range of 0.01-0.2 µg/L. The recoveries ranged from 70% to 110% with RSD% < 10%. The results indicate that M-S-RGO is an efficient and selective adsorbent for the extraction and cleanup of basic dyes. Due to the MSPE procedures, matrix effect and interference were eliminated in the analysis of HPLC-MS/MS without the matrix-matched standards. Thus, validation data showed that the proposed MSPE-HPLC-MS/MS method was rapid, efficient, selective, and sensitive for the determination of illegal basic dyes in foods.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules26247427</identifier><identifier>PMID: 34946507</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adsorption ; Basic dyes ; Basic oxides ; Calibration ; Carbon ; Chemical bonds ; Chromatography ; Chromatography, High Pressure Liquid ; Composite materials ; Correlation coefficient ; Correlation coefficients ; Dyes ; Efficiency ; Food ; Food Analysis ; Food Coloring Agents - analysis ; Food Contamination - analysis ; Food dyes ; functionalized graphene oxide ; Graphene ; Graphite - chemistry ; High performance liquid chromatography ; HPLC–MS/MS ; illegal food dyes ; Liquid chromatography ; Magnetic fields ; Magnetic Phenomena ; Mass spectrometry ; Mass spectroscopy ; Methods ; MSPE method ; Nanomaterials ; Solid Phase Extraction ; Solid phases ; Solvents ; Sulfonic Acids - chemistry ; Sulfur content ; Tandem Mass Spectrometry</subject><ispartof>Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7427</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-77dba9dc955180054416ba541c6bdc0a5da86e3c53da5770a53ba9a9e9dd109c3</citedby><cites>FETCH-LOGICAL-c493t-77dba9dc955180054416ba541c6bdc0a5da86e3c53da5770a53ba9a9e9dd109c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708935/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708935/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34946507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Shibo</creatorcontrib><creatorcontrib>Mao, Xinwu</creatorcontrib><creatorcontrib>Zhang, Haijing</creatorcontrib><creatorcontrib>Zeng, Haowei</creatorcontrib><creatorcontrib>Lin, Zihao</creatorcontrib><creatorcontrib>Zhang, Xuewu</creatorcontrib><creatorcontrib>Qi, Ping</creatorcontrib><title>Magnetic Solid-Phase Extraction Based on Magnetic Sulfonated Reduced Graphene Oxide for HPLC-MS/MS Analysis of Illegal Basic Dyes in Foods</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>In this study, a magnetic solid-phase extraction (MSPE) method coupled with High-Performance Liquid Chromatography Mass Spectrometry (HPLC-MS/MS) for the determination of illegal basic dyes in food samples was developed and validated. This method was based on Magnetic sulfonated reduced graphene oxide (M-S-RGO), which was sensitive and selective to analytes with structure of multiaromatic rings and negatively charged ions. Several factors affecting MSPE efficiency such as pH and adsorption time were optimized. Under the optimum conditions, the calibration curves exhibited good linearity, ranging from 5 to 60 µg/g with correlation coefficients >0.9950. The limits of detection of 16 basic dyes were in the range of 0.01-0.2 µg/L. The recoveries ranged from 70% to 110% with RSD% < 10%. The results indicate that M-S-RGO is an efficient and selective adsorbent for the extraction and cleanup of basic dyes. Due to the MSPE procedures, matrix effect and interference were eliminated in the analysis of HPLC-MS/MS without the matrix-matched standards. Thus, validation data showed that the proposed MSPE-HPLC-MS/MS method was rapid, efficient, selective, and sensitive for the determination of illegal basic dyes in foods.</description><subject>Adsorption</subject><subject>Basic dyes</subject><subject>Basic oxides</subject><subject>Calibration</subject><subject>Carbon</subject><subject>Chemical bonds</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Composite materials</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Dyes</subject><subject>Efficiency</subject><subject>Food</subject><subject>Food Analysis</subject><subject>Food Coloring Agents - analysis</subject><subject>Food Contamination - analysis</subject><subject>Food dyes</subject><subject>functionalized graphene oxide</subject><subject>Graphene</subject><subject>Graphite - chemistry</subject><subject>High performance liquid chromatography</subject><subject>HPLC–MS/MS</subject><subject>illegal food dyes</subject><subject>Liquid chromatography</subject><subject>Magnetic fields</subject><subject>Magnetic Phenomena</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Methods</subject><subject>MSPE method</subject><subject>Nanomaterials</subject><subject>Solid Phase Extraction</subject><subject>Solid phases</subject><subject>Solvents</subject><subject>Sulfonic Acids - chemistry</subject><subject>Sulfur content</subject><subject>Tandem Mass Spectrometry</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNplkktvEzEQx1eIipbCB-CCLHHhstTP9fqCVEIfkRK1InC2Zm1vspGzDvYuar4Cnxq3KX3AacYz__lpZjxF8Y7gT4wpfLIJ3pnRu0QryiWn8kVxRDjFJcNcvXziHxavU1pjTAkn4lVxyLjilcDyqPg9h2Xvhs6gRfCdLa9XkBw6uxkimKELPfqS3xZl51E4-jb0MOTwN2dHk-1FhO3K9Q5d3XTWoTZEdHk9m5Tzxcl8gU578LvUJRRaNPXeLcHfYjPq684l1PXoPASb3hQHLfjk3t7b4-LH-dn3yWU5u7qYTk5npeGKDaWUtgFljRKC1BgLzknVgODEVI01GISFunLMCGZBSJkDLOtBOWUtwcqw42K659oAa72N3QbiTgfo9F0gxKWGmAf1TvOWGwHSspZgzkijlATCq4qY3APnkFmf96zt2GycNa7Pi_PPoM8zfbfSy_BL1xLXiokM-HgPiOHn6NKgN10yznvoXRiTplX-REYVZln64R_pOowx7_ZORWuKa0yziuxVJoaUomsfmiFY316N_u9qcs37p1M8VPw9E_YHWmzAJQ</recordid><startdate>20211207</startdate><enddate>20211207</enddate><creator>Cui, Shibo</creator><creator>Mao, Xinwu</creator><creator>Zhang, Haijing</creator><creator>Zeng, Haowei</creator><creator>Lin, Zihao</creator><creator>Zhang, Xuewu</creator><creator>Qi, Ping</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211207</creationdate><title>Magnetic Solid-Phase Extraction Based on Magnetic Sulfonated Reduced Graphene Oxide for HPLC-MS/MS Analysis of Illegal Basic Dyes in Foods</title><author>Cui, Shibo ; Mao, Xinwu ; Zhang, Haijing ; Zeng, Haowei ; Lin, Zihao ; Zhang, Xuewu ; Qi, Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-77dba9dc955180054416ba541c6bdc0a5da86e3c53da5770a53ba9a9e9dd109c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adsorption</topic><topic>Basic dyes</topic><topic>Basic oxides</topic><topic>Calibration</topic><topic>Carbon</topic><topic>Chemical bonds</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Composite materials</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Dyes</topic><topic>Efficiency</topic><topic>Food</topic><topic>Food Analysis</topic><topic>Food Coloring Agents - analysis</topic><topic>Food Contamination - analysis</topic><topic>Food dyes</topic><topic>functionalized graphene oxide</topic><topic>Graphene</topic><topic>Graphite - chemistry</topic><topic>High performance liquid chromatography</topic><topic>HPLC–MS/MS</topic><topic>illegal food dyes</topic><topic>Liquid chromatography</topic><topic>Magnetic fields</topic><topic>Magnetic Phenomena</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Methods</topic><topic>MSPE method</topic><topic>Nanomaterials</topic><topic>Solid Phase Extraction</topic><topic>Solid phases</topic><topic>Solvents</topic><topic>Sulfonic Acids - chemistry</topic><topic>Sulfur content</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Shibo</creatorcontrib><creatorcontrib>Mao, Xinwu</creatorcontrib><creatorcontrib>Zhang, Haijing</creatorcontrib><creatorcontrib>Zeng, Haowei</creatorcontrib><creatorcontrib>Lin, Zihao</creatorcontrib><creatorcontrib>Zhang, Xuewu</creatorcontrib><creatorcontrib>Qi, Ping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Shibo</au><au>Mao, Xinwu</au><au>Zhang, Haijing</au><au>Zeng, Haowei</au><au>Lin, Zihao</au><au>Zhang, Xuewu</au><au>Qi, Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Solid-Phase Extraction Based on Magnetic Sulfonated Reduced Graphene Oxide for HPLC-MS/MS Analysis of Illegal Basic Dyes in Foods</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2021-12-07</date><risdate>2021</risdate><volume>26</volume><issue>24</issue><spage>7427</spage><pages>7427-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>In this study, a magnetic solid-phase extraction (MSPE) method coupled with High-Performance Liquid Chromatography Mass Spectrometry (HPLC-MS/MS) for the determination of illegal basic dyes in food samples was developed and validated. This method was based on Magnetic sulfonated reduced graphene oxide (M-S-RGO), which was sensitive and selective to analytes with structure of multiaromatic rings and negatively charged ions. Several factors affecting MSPE efficiency such as pH and adsorption time were optimized. Under the optimum conditions, the calibration curves exhibited good linearity, ranging from 5 to 60 µg/g with correlation coefficients >0.9950. The limits of detection of 16 basic dyes were in the range of 0.01-0.2 µg/L. The recoveries ranged from 70% to 110% with RSD% < 10%. The results indicate that M-S-RGO is an efficient and selective adsorbent for the extraction and cleanup of basic dyes. Due to the MSPE procedures, matrix effect and interference were eliminated in the analysis of HPLC-MS/MS without the matrix-matched standards. Thus, validation data showed that the proposed MSPE-HPLC-MS/MS method was rapid, efficient, selective, and sensitive for the determination of illegal basic dyes in foods.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34946507</pmid><doi>10.3390/molecules26247427</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adsorption Basic dyes Basic oxides Calibration Carbon Chemical bonds Chromatography Chromatography, High Pressure Liquid Composite materials Correlation coefficient Correlation coefficients Dyes Efficiency Food Food Analysis Food Coloring Agents - analysis Food Contamination - analysis Food dyes functionalized graphene oxide Graphene Graphite - chemistry High performance liquid chromatography HPLC–MS/MS illegal food dyes Liquid chromatography Magnetic fields Magnetic Phenomena Mass spectrometry Mass spectroscopy Methods MSPE method Nanomaterials Solid Phase Extraction Solid phases Solvents Sulfonic Acids - chemistry Sulfur content Tandem Mass Spectrometry |
| title | Magnetic Solid-Phase Extraction Based on Magnetic Sulfonated Reduced Graphene Oxide for HPLC-MS/MS Analysis of Illegal Basic Dyes in Foods |
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