Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration

Breast cancer resistance protein (BCRP), one of the ATP-binding cassette (ABC) transporters, was associated with the multidrug resistance (MDR) of chemotherapy. Magnolol (MN) and honokiol (HK) are major bioactive polyphenols of Magnolia officinalis. This study investigated the effects of MN and HK o...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-12, Vol.26 (23), p.7390, Article 7390
Hauptverfasser:	Yu, Chung-Ping, Li, Pei-Ying, Chen, Szu-Yu, Lin, Shiuan-Pey, Hou, Yu-Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase ABC transporters Angiogenesis Animals Apoptosis ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism BCRP Biochemistry & Molecular Biology Biphenyl Compounds - metabolism Biphenyl Compounds - pharmacology Breast cancer Cancer therapies Cell Survival - drug effects Chemistry Chemistry, Multidisciplinary Chemotherapy Dogs Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Drugs EGFR Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - metabolism Growth factors honokiol Investigations Life Sciences & Biomedicine Lignans - metabolism Lignans - pharmacology Madin Darby Canine Kidney Cells Magnolia - chemistry magnolol MDR Multidrug resistance Neoplasm Proteins - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Physical Sciences Plant Extracts - metabolism Plant Extracts - pharmacology Polyphenols Polyphenols - metabolism Polyphenols - pharmacology Proteins Science & Technology Signal transduction Signal Transduction - drug effects
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