Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR)....
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| Veröffentlicht in: | Materials 2020-10, Vol.13 (21), p.4770, Article 4770 |
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| creator | Okamura, Tomoharu Chen, Liji Tsumano, Nobuhito Ikeda, Chihoko Komasa, Satoshi Tominaga, Kazuya Hashimoto, Yoshiya |
| description | The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs' teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients. |
| doi_str_mv | 10.3390/ma13214770 |
| format | Article |
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In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs' teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma13214770</identifier><identifier>PMID: 33114595</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Biocompatibility ; Calcium silicate hydrate ; Calcium silicates ; Chemical elements ; Chemistry ; Chemistry, Physical ; Cytotoxicity ; Dogs ; Endodontics ; Fibroblasts ; Fourier transforms ; Hydraulics ; Infrared spectroscopy ; Materials Science ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering ; Physical Sciences ; Physics ; Physics, Applied ; Physics, Condensed Matter ; Plastic properties ; Polyethylene glycol ; Roots ; Scanning electron microscopy ; Science & Technology ; Sealing compounds ; Silica ; Slaked lime ; Technology ; Teeth ; Toxicity ; Water chemistry ; X-ray diffraction</subject><ispartof>Materials, 2020-10, Vol.13 (21), p.4770, Article 4770</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>15</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000589330000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c449t-818b2fc09960001707dc84e4b0e7687ce6044317d8d60e373480912c123c83633</citedby><cites>FETCH-LOGICAL-c449t-818b2fc09960001707dc84e4b0e7687ce6044317d8d60e373480912c123c83633</cites><orcidid>0000-0002-7082-5804 ; 0000-0001-5400-8479</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663406/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663406/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids></links><search><creatorcontrib>Okamura, Tomoharu</creatorcontrib><creatorcontrib>Chen, Liji</creatorcontrib><creatorcontrib>Tsumano, Nobuhito</creatorcontrib><creatorcontrib>Ikeda, Chihoko</creatorcontrib><creatorcontrib>Komasa, Satoshi</creatorcontrib><creatorcontrib>Tominaga, Kazuya</creatorcontrib><creatorcontrib>Hashimoto, Yoshiya</creatorcontrib><title>Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material</title><title>Materials</title><addtitle>MATERIALS</addtitle><description>The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs' teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients.</description><subject>Biocompatibility</subject><subject>Calcium silicate hydrate</subject><subject>Calcium silicates</subject><subject>Chemical elements</subject><subject>Chemistry</subject><subject>Chemistry, Physical</subject><subject>Cytotoxicity</subject><subject>Dogs</subject><subject>Endodontics</subject><subject>Fibroblasts</subject><subject>Fourier transforms</subject><subject>Hydraulics</subject><subject>Infrared spectroscopy</subject><subject>Materials Science</subject><subject>Materials Science, Multidisciplinary</subject><subject>Metallurgy & Metallurgical Engineering</subject><subject>Physical Sciences</subject><subject>Physics</subject><subject>Physics, Applied</subject><subject>Physics, Condensed Matter</subject><subject>Plastic properties</subject><subject>Polyethylene glycol</subject><subject>Roots</subject><subject>Scanning electron microscopy</subject><subject>Science & Technology</subject><subject>Sealing compounds</subject><subject>Silica</subject><subject>Slaked lime</subject><subject>Technology</subject><subject>Teeth</subject><subject>Toxicity</subject><subject>Water chemistry</subject><subject>X-ray diffraction</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkUtP3TAQhS3UqiDKpr8gEpuqJcUTO35sKpWIlkqgVjzWluNMwCiJL7HT6v57TC8C2lVn49HM56NjH0LeAf3EmKaHowVWAZeSbpEd0FqUoDl_9aLfJnsx3tJcjIGq9BuynRvgta53yOWRDy6MK5t86wef1kXoC1uc-Oub8udgY_IuDw-Kxg7OL2NxkSFnE5ZHNmJ3UJyj7dZlCuVVxOIsL2Zvh7fkdW-HiHuP5y65-np82ZyUpz--fW--nJaOc51KBaqtekez0WwOJJWdUxx5S1EKJR0KyjkD2alOUGSScUU1VA4q5hQTjO2Szxvd1dKO2Dmc0mwHs5r9aOe1CdabvzeTvzHX4ZeRQjBORRZ4_ygwh7sFYzKjjw6HwU4YlmgqXteKAQWd0f1_0NuwzFN-nqlqrmQloH4Q_LCh3BxinLF_MgPUPORlnvPK8McN_Bvb0EfncXL4dCF_Sa00Y_RPQabV_9ONTznRMDVhmRK7B3L6pF0</recordid><startdate>20201026</startdate><enddate>20201026</enddate><creator>Okamura, Tomoharu</creator><creator>Chen, Liji</creator><creator>Tsumano, Nobuhito</creator><creator>Ikeda, Chihoko</creator><creator>Komasa, Satoshi</creator><creator>Tominaga, Kazuya</creator><creator>Hashimoto, Yoshiya</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7082-5804</orcidid><orcidid>https://orcid.org/0000-0001-5400-8479</orcidid></search><sort><creationdate>20201026</creationdate><title>Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material</title><author>Okamura, Tomoharu ; 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In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs' teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>33114595</pmid><doi>10.3390/ma13214770</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7082-5804</orcidid><orcidid>https://orcid.org/0000-0001-5400-8479</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Calcium silicate hydrate Calcium silicates Chemical elements Chemistry Chemistry, Physical Cytotoxicity Dogs Endodontics Fibroblasts Fourier transforms Hydraulics Infrared spectroscopy Materials Science Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Physical Sciences Physics Physics, Applied Physics, Condensed Matter Plastic properties Polyethylene glycol Roots Scanning electron microscopy Science & Technology Sealing compounds Silica Slaked lime Technology Teeth Toxicity Water chemistry X-ray diffraction |
| title | Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material |
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