Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES)
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES)...
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| Veröffentlicht in: | Journal of clinical medicine 2025-01, Vol.14 (2), p.498 |
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| creator | Benito-Rodríguez, Carla María Bermejo-Pareja, Félix Berbel, Angel Lapeña-Motilva, José Benito-León, Julián |
| description | Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a comprehensive 23-year mortality analysis in a Spanish population.
In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994-1995) and follow-up (1997-1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables.
Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31-2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24-3.89). Early-onset PD ( |
| doi_str_mv | 10.3390/jcm14020498 |
| format | Article |
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In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994-1995) and follow-up (1997-1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables.
Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31-2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24-3.89). Early-onset PD (<65 years) showed heightened mortality risk (HR = 2.11; 95% CI = 1.22-3.64). Cardiovascular and cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD patients compared to the reference group (14.7% vs. 0.4%,
< 0.001).
PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings underscore the importance of a multidisciplinary approach to PD care, targeting both motor and non-motor symptoms to enhance long-term outcomes.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm14020498</identifier><identifier>PMID: 39860502</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aging ; Cognitive ability ; Dementia ; Disease ; Longitudinal studies ; Mental disorders ; Mortality ; Neurological disorders ; Population-based studies ; Questionnaires ; Tremor (Muscular contraction)</subject><ispartof>Journal of clinical medicine, 2025-01, Vol.14 (2), p.498</ispartof><rights>2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2025 by the authors. 2025</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2138-25aacf76b3ba56a217e478657e9fd1d83e7a33c616d81202490a0c661c29ee753</cites><orcidid>0000-0002-1769-4809 ; 0000-0001-6359-5097</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765759/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765759/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39860502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benito-Rodríguez, Carla María</creatorcontrib><creatorcontrib>Bermejo-Pareja, Félix</creatorcontrib><creatorcontrib>Berbel, Angel</creatorcontrib><creatorcontrib>Lapeña-Motilva, José</creatorcontrib><creatorcontrib>Benito-León, Julián</creatorcontrib><title>Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES)</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a comprehensive 23-year mortality analysis in a Spanish population.
In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994-1995) and follow-up (1997-1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables.
Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31-2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24-3.89). Early-onset PD (<65 years) showed heightened mortality risk (HR = 2.11; 95% CI = 1.22-3.64). Cardiovascular and cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD patients compared to the reference group (14.7% vs. 0.4%,
< 0.001).
PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings underscore the importance of a multidisciplinary approach to PD care, targeting both motor and non-motor symptoms to enhance long-term outcomes.</description><subject>Aging</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Disease</subject><subject>Longitudinal studies</subject><subject>Mental disorders</subject><subject>Mortality</subject><subject>Neurological disorders</subject><subject>Population-based studies</subject><subject>Questionnaires</subject><subject>Tremor (Muscular contraction)</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1P4zAQxS0EAgScuCNLHChCYf2R2A4XBKXsIrG7lSgHTpbrTMEljYudgPrfY5YPlfXF1vinN_PmIbRLyTHnJfkxtTOaE0byUq2gTUakzAhXfHXpvYF2YpySdJTKGZXraIOXSpCCsE00Hr1A0y6y0UMAyO7ABPzbh9bUrl1g1-ChCY-uib45iPjCRTARTvAZHvp5V5vW-SY7T6UKD4OPc7CtewZ803bVAvf-DC6u-oObw220NjF1hJ2PewvdXg5G_V_Z9d-fV_2z68wyylXGCmPsRIoxH5tCmDQo5FKJQkI5qWilOEjDuRVUVIoywvKSGGKFoJaVALLgW-j0XXfejWdQ2eQrmFrPg5uZsNDeOP39p3EP-t4_a0plalOUSaH3oRD8Uwex1TMXLdS1acB3UXNalIowRd-a7f-HTn0XmuTvH5ULViiVqKN3yqb1xACTr2ko0W_56aX8Er23bOCL_UyLvwK5NJRU</recordid><startdate>20250114</startdate><enddate>20250114</enddate><creator>Benito-Rodríguez, Carla María</creator><creator>Bermejo-Pareja, Félix</creator><creator>Berbel, Angel</creator><creator>Lapeña-Motilva, José</creator><creator>Benito-León, Julián</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1769-4809</orcidid><orcidid>https://orcid.org/0000-0001-6359-5097</orcidid></search><sort><creationdate>20250114</creationdate><title>Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES)</title><author>Benito-Rodríguez, Carla María ; Bermejo-Pareja, Félix ; Berbel, Angel ; Lapeña-Motilva, José ; Benito-León, Julián</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2138-25aacf76b3ba56a217e478657e9fd1d83e7a33c616d81202490a0c661c29ee753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Aging</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Disease</topic><topic>Longitudinal studies</topic><topic>Mental disorders</topic><topic>Mortality</topic><topic>Neurological disorders</topic><topic>Population-based studies</topic><topic>Questionnaires</topic><topic>Tremor (Muscular contraction)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benito-Rodríguez, Carla María</creatorcontrib><creatorcontrib>Bermejo-Pareja, Félix</creatorcontrib><creatorcontrib>Berbel, Angel</creatorcontrib><creatorcontrib>Lapeña-Motilva, José</creatorcontrib><creatorcontrib>Benito-León, Julián</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benito-Rodríguez, Carla María</au><au>Bermejo-Pareja, Félix</au><au>Berbel, Angel</au><au>Lapeña-Motilva, José</au><au>Benito-León, Julián</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES)</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2025-01-14</date><risdate>2025</risdate><volume>14</volume><issue>2</issue><spage>498</spage><pages>498-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a comprehensive 23-year mortality analysis in a Spanish population.
In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994-1995) and follow-up (1997-1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables.
Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31-2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24-3.89). Early-onset PD (<65 years) showed heightened mortality risk (HR = 2.11; 95% CI = 1.22-3.64). Cardiovascular and cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD patients compared to the reference group (14.7% vs. 0.4%,
< 0.001).
PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings underscore the importance of a multidisciplinary approach to PD care, targeting both motor and non-motor symptoms to enhance long-term outcomes.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39860502</pmid><doi>10.3390/jcm14020498</doi><orcidid>https://orcid.org/0000-0002-1769-4809</orcidid><orcidid>https://orcid.org/0000-0001-6359-5097</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical medicine, 2025-01, Vol.14 (2), p.498 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Aging Cognitive ability Dementia Disease Longitudinal studies Mental disorders Mortality Neurological disorders Population-based studies Questionnaires Tremor (Muscular contraction) |
| title | Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES) |
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