Calcium Signaling Silencing in Atrial Fibrillation: Implications for Atrial Sodium Homeostasis

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, affecting more than 33 million people worldwide. Despite important advances in therapy, AF's incidence remains high, and treatment often results in recurrence of the arrhythmia. A better understanding of the cellular and mo...

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Veröffentlicht in:	International journal of molecular sciences 2021-09, Vol.22 (19), p.10513, Article 10513
Hauptverfasser:	Kaplan, Aaron D., Joca, Humberto C., Boyman, Liron, Greiser, Maura
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmia atrial fibrillation Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology atrial myocytes Biochemistry & Molecular Biology Ca2+ handling Calcium (intracellular) Calcium - metabolism Calcium ions Calcium Signaling - physiology calcium signaling silencing Calcium signalling Cardiac arrhythmia Cardiomyocytes Chemistry Chemistry, Multidisciplinary Clinical trials Fibrillation Handling Heart Heart failure Homeostasis Homeostasis - physiology Humans Intracellular Intracellular signalling Life Sciences & Biomedicine Myocytes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Na+ concentration Na+ currents Pharmacology Physical Sciences Review Sarcolemma - metabolism Science & Technology Sodium Sodium - metabolism Sodium-Calcium Exchanger - metabolism Therapeutic targets
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