Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
Damage to the tissue and the ruining of functions characterize autoimmune syndromes. This review centers around leaky gut syndromes and how they stimulate autoimmune pathogenesis. Lymphoid tissue commonly associated with the gut, together with the neuroendocrine network, collaborates with the intest...
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| Veröffentlicht in: | International journal of molecular sciences 2020-12, Vol.21 (24), p.9770, Article 9770 |
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| creator | Paray, Bilal Ahmad Albeshr, Mohammed Fahad Jan, Arif Tasleem Rather, Irfan A. |
| description | Damage to the tissue and the ruining of functions characterize autoimmune syndromes. This review centers around leaky gut syndromes and how they stimulate autoimmune pathogenesis. Lymphoid tissue commonly associated with the gut, together with the neuroendocrine network, collaborates with the intestinal epithelial wall, with its paracellular tight junctions, to maintain the balance, tolerance, and resistance to foreign/neo-antigens. The physiological regulator of paracellular tight junctions plays a vital role in transferring macromolecules across the intestinal barrier and thereby maintains immune response equilibrium. A new paradigm has explained the intricacies of disease development and proposed that the processes can be prevented if the interaction between the genetic factor and environmental causes is barred by re-instituting the intestinal wall function. The latest clinical evidence and animal models reinforce this current thought and offer the basis for innovative methodologies to thwart and treat autoimmune syndromes. |
| doi_str_mv | 10.3390/ijms21249770 |
| format | Article |
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This review centers around leaky gut syndromes and how they stimulate autoimmune pathogenesis. Lymphoid tissue commonly associated with the gut, together with the neuroendocrine network, collaborates with the intestinal epithelial wall, with its paracellular tight junctions, to maintain the balance, tolerance, and resistance to foreign/neo-antigens. The physiological regulator of paracellular tight junctions plays a vital role in transferring macromolecules across the intestinal barrier and thereby maintains immune response equilibrium. A new paradigm has explained the intricacies of disease development and proposed that the processes can be prevented if the interaction between the genetic factor and environmental causes is barred by re-instituting the intestinal wall function. 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| subjects | Animals Autoimmune Diseases - etiology Autoimmune Diseases - pathology autoimmune disorders Biochemistry & Molecular Biology Cell Membrane Permeability Chemistry Chemistry, Multidisciplinary Gastrointestinal Tract - immunology Gastrointestinal Tract - pathology Humans immune system intestinal wall Life Sciences & Biomedicine microbiota Physical Sciences Review Science & Technology |
| title | Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State |
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