Exposure of Triclosan in Porcine Oocyte Leads to Superoxide Production and Mitochondrial-Mediated Apoptosis during In Vitro Maturation

While triclosan (TCS) exerts detrimental effects on female reproduction, the effect of TCS-derived toxins on porcine oocytes during in vitro maturation (IVM) is unclear. This study investigated the effects of TCS on mitochondrion-derived reactive oxygen species (ROS) production and apoptosis pathway...

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Veröffentlicht in:	International journal of molecular sciences 2020-04, Vol.21 (9), p.3050, Article 3050
Hauptverfasser:	Park, Hyo-Jin, Song, Bong-Seok, Kim, Jin-Woo, Yang, Seul-Gi, Kim, Sun-Uk, Koo, Deog-Bon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary cumulus cell expansion Cumulus Cells - cytology Cumulus Cells - drug effects Cumulus Cells - metabolism Female Gene Expression Regulation - drug effects In Vitro Oocyte Maturation Techniques Life Sciences & Biomedicine Mito-TEMPO Mitochondria - metabolism Oocytes - cytology Oocytes - drug effects Oocytes - metabolism Organophosphorus Compounds - pharmacology Organophosphorus Compounds - toxicity Oxidative Stress - drug effects Physical Sciences Piperidines - toxicity porcine oocyte maturation Science & Technology superoxide Superoxides - metabolism Swine triclosan Triclosan - toxicity
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