Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart

We present data showing that Iodotyrosine Deiodinase (IYD) is a dual-function enzyme acting as a catalyst in metabolism and a receptor for cooperative stem cell differentiation. IYD is present both in thyroid cells where it is critical for scavenging iodine from halogenated by-products of thyroid ho...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2020-01, Vol.9 (1), p.256, Article 256
Hauptverfasser:	Han, Kyung Ho, Arlian, Britni M., Lin, Chih-Wei, Jin, Hyun Yong, Kang, Geun-Hyung, Lee, Sahmin, Lee, Peter Chang-Whan, Lerner, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes, Brown - cytology Adipocytes, Brown - drug effects Adipocytes, Brown - ultrastructure Agonists Animals Antibodies Antibodies - pharmacology antibody Antibody libraries Bone marrow brown adipocyte-like cells Catalysts Cell Biology Cell differentiation Cell Differentiation - drug effects Cell migration Cell Movement - drug effects Enzymes Flow cytometry Gene expression Heart Hematopoietic stem cells Humans Iodide peroxidase Iodine iodotyrosine deiodinase (iyd) Laboratories Life Sciences & Biomedicine Ligands Mice Microscopy Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Myocardium Myocardium - cytology Myocardium - ultrastructure Physiology Proteins Science & Technology Stem cell transplantation Stem cells Stem Cells - cytology Stem Cells - drug effects Thermogenesis Thyroid Thyroid gland
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