NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective
Cancer increases the global disease burden substantially, but it remains a challenge to manage it. The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F...
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| Veröffentlicht in: | Cells (Basel, Switzerland) Switzerland), 2021-08, Vol.10 (9), p.2176 |
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| creator | Arshad, Maria Abdul Hamid, Nazefah Chan, Mun Chiang Ismail, Fuad Tan, Geok Chin Pezzella, Francesco Tan, Ka-Liong |
| description | Cancer increases the global disease burden substantially, but it remains a challenge to manage it. The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F-adjacent transcript 10 (FAT10) proteins as novel biomarkers in cancer. This literature review is based on the search of the electronic database, PubMed. NUB1 is an interferon-inducible protein that mediates apoptotic and anti-proliferative actions in cancer, while FAT10 is a ubiquitin-like modifier that promotes cancer. The upregulated expression of both NUB1 and FAT10 has been observed in various cancers. NUB1 protein binds to FAT10 non-covalently to promote FAT10 degradation. An overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest deficient 2 protein, causing chromosomal instability and breast tumourigenesis. FAT10 binds to the proliferating cell nuclear antigen protein and inhibits the DNA damage repair response. In addition, FAT10 involves epithelial-mesenchymal transition, invasion, apoptosis, and multiplication in hepatocellular carcinoma. Our knowledge about them is still limited. There is a need to further develop NUB1 and FAT10 as novel biomarkers. |
| doi_str_mv | 10.3390/cells10092176 |
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The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F-adjacent transcript 10 (FAT10) proteins as novel biomarkers in cancer. This literature review is based on the search of the electronic database, PubMed. NUB1 is an interferon-inducible protein that mediates apoptotic and anti-proliferative actions in cancer, while FAT10 is a ubiquitin-like modifier that promotes cancer. The upregulated expression of both NUB1 and FAT10 has been observed in various cancers. NUB1 protein binds to FAT10 non-covalently to promote FAT10 degradation. An overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest deficient 2 protein, causing chromosomal instability and breast tumourigenesis. FAT10 binds to the proliferating cell nuclear antigen protein and inhibits the DNA damage repair response. In addition, FAT10 involves epithelial-mesenchymal transition, invasion, apoptosis, and multiplication in hepatocellular carcinoma. Our knowledge about them is still limited. There is a need to further develop NUB1 and FAT10 as novel biomarkers.</description><identifier>ISSN: 2073-4409</identifier><identifier>EISSN: 2073-4409</identifier><identifier>DOI: 10.3390/cells10092176</identifier><identifier>PMID: 34571823</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Apoptosis ; B cells ; Biological markers ; Biological response modifiers ; biomarker ; Biomarkers ; Biomarkers, Tumor - metabolism ; Breast ; Breast cancer ; Cancer ; Cancer therapies ; Carcinogenesis - metabolism ; Carcinogenesis - pathology ; Cell cycle ; Cell Proliferation - physiology ; Chemical bonds ; Development and progression ; DNA damage ; DNA repair ; Enzymes ; FAT10 ; Gastric cancer ; Gene expression ; Genomic instability ; Hepatitis B ; Hepatocellular carcinoma ; Humans ; Inflammation ; Interferon ; Interferon-inducible protein ; Kinases ; Literature reviews ; Liver cancer ; Mesenchyme ; Molecular weight ; Neoplasms - metabolism ; Neoplasms - pathology ; NUB1 ; NUB1L ; Oncology, Experimental ; Phase transitions ; Proliferating cell nuclear antigen ; Protein binding ; Protein research ; Proteins ; Review ; Risk assessment ; Transcription ; Translational research ; Tumor necrosis factor-TNF ; Tumors ; Ubiquitin ; Ubiquitins - metabolism</subject><ispartof>Cells (Basel, Switzerland), 2021-08, Vol.10 (9), p.2176</ispartof><rights>COPYRIGHT 2021 MDPI AG</rights><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-dcced0518268006d028da24fae0148ec8b6b967c678ce85dc4f87d80f81a20aa3</citedby><cites>FETCH-LOGICAL-c548t-dcced0518268006d028da24fae0148ec8b6b967c678ce85dc4f87d80f81a20aa3</cites><orcidid>0000-0001-5811-8018 ; 0000-0002-2289-7619 ; 0000-0003-2779-8123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468723/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468723/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34571823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arshad, Maria</creatorcontrib><creatorcontrib>Abdul Hamid, Nazefah</creatorcontrib><creatorcontrib>Chan, Mun Chiang</creatorcontrib><creatorcontrib>Ismail, Fuad</creatorcontrib><creatorcontrib>Tan, Geok Chin</creatorcontrib><creatorcontrib>Pezzella, Francesco</creatorcontrib><creatorcontrib>Tan, Ka-Liong</creatorcontrib><title>NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective</title><title>Cells (Basel, Switzerland)</title><addtitle>Cells</addtitle><description>Cancer increases the global disease burden substantially, but it remains a challenge to manage it. The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F-adjacent transcript 10 (FAT10) proteins as novel biomarkers in cancer. This literature review is based on the search of the electronic database, PubMed. NUB1 is an interferon-inducible protein that mediates apoptotic and anti-proliferative actions in cancer, while FAT10 is a ubiquitin-like modifier that promotes cancer. The upregulated expression of both NUB1 and FAT10 has been observed in various cancers. NUB1 protein binds to FAT10 non-covalently to promote FAT10 degradation. An overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest deficient 2 protein, causing chromosomal instability and breast tumourigenesis. FAT10 binds to the proliferating cell nuclear antigen protein and inhibits the DNA damage repair response. In addition, FAT10 involves epithelial-mesenchymal transition, invasion, apoptosis, and multiplication in hepatocellular carcinoma. Our knowledge about them is still limited. There is a need to further develop NUB1 and FAT10 as novel biomarkers.</description><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>B cells</subject><subject>Biological markers</subject><subject>Biological response modifiers</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinogenesis - metabolism</subject><subject>Carcinogenesis - pathology</subject><subject>Cell cycle</subject><subject>Cell Proliferation - physiology</subject><subject>Chemical bonds</subject><subject>Development and progression</subject><subject>DNA damage</subject><subject>DNA repair</subject><subject>Enzymes</subject><subject>FAT10</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genomic instability</subject><subject>Hepatitis B</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Interferon-inducible protein</subject><subject>Kinases</subject><subject>Literature reviews</subject><subject>Liver cancer</subject><subject>Mesenchyme</subject><subject>Molecular weight</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>NUB1</subject><subject>NUB1L</subject><subject>Oncology, Experimental</subject><subject>Phase transitions</subject><subject>Proliferating cell nuclear antigen</subject><subject>Protein binding</subject><subject>Protein research</subject><subject>Proteins</subject><subject>Review</subject><subject>Risk assessment</subject><subject>Transcription</subject><subject>Translational research</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Ubiquitin</subject><subject>Ubiquitins - metabolism</subject><issn>2073-4409</issn><issn>2073-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1vEzEQhlcI1Falx16RJS5cttjrz-WAlEa0VKpKDukNyZq1vcFhYwd7E4l_X6cppUHYB4_Gz7yeGU9VnRN8QWmLPxo3DJlg3DZEilfVSYMlrRnD7esX9nF1lvMSl6WIIJgfVceUcUlUQ0-q73f3lwRBsOhqMicYzVIcnQ8ZQUazYobRw4Du4tYN6NLHFaSfLmXkA5pCMC59QhM0TxDyAKOPobCzcr92ZvRb97Z608OQ3dnTeVrdX32ZT7_Wt9-ub6aT29pwpsbaGuMs5iUhoTAWFjfKQsN6cJgw5YzqRNcKaYRUxiluDeuVtAr3ikCDAehpdbPXtRGWep18SfO3juD1oyOmhYY0ejM4TUEJJpW13CnWWd61tuh01hIDRkBXtD7vtdabbuWsKR1IMByIHt4E_0Mv4lYrJpRsaBH48CSQ4q-Ny6Ne-bz7KAgubrJuuJSMtxjzgr7_B13GTSpNfKQEbakk7V9qAaUAH_pY3jU7UT1RhCjGMWsKdfEfqmzrVt7E4Hpf_AcB9T7ApJhzcv1zjQTr3XTpg-kq_LuXjXmm_8wSfQApfMk_</recordid><startdate>20210824</startdate><enddate>20210824</enddate><creator>Arshad, Maria</creator><creator>Abdul Hamid, Nazefah</creator><creator>Chan, Mun Chiang</creator><creator>Ismail, Fuad</creator><creator>Tan, Geok Chin</creator><creator>Pezzella, Francesco</creator><creator>Tan, Ka-Liong</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5811-8018</orcidid><orcidid>https://orcid.org/0000-0002-2289-7619</orcidid><orcidid>https://orcid.org/0000-0003-2779-8123</orcidid></search><sort><creationdate>20210824</creationdate><title>NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective</title><author>Arshad, Maria ; Abdul Hamid, Nazefah ; Chan, Mun Chiang ; Ismail, Fuad ; Tan, Geok Chin ; Pezzella, Francesco ; Tan, Ka-Liong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-dcced0518268006d028da24fae0148ec8b6b967c678ce85dc4f87d80f81a20aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>B cells</topic><topic>Biological markers</topic><topic>Biological response modifiers</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinogenesis - metabolism</topic><topic>Carcinogenesis - pathology</topic><topic>Cell cycle</topic><topic>Cell Proliferation - physiology</topic><topic>Chemical bonds</topic><topic>Development and progression</topic><topic>DNA damage</topic><topic>DNA repair</topic><topic>Enzymes</topic><topic>FAT10</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genomic instability</topic><topic>Hepatitis B</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Interferon-inducible protein</topic><topic>Kinases</topic><topic>Literature reviews</topic><topic>Liver cancer</topic><topic>Mesenchyme</topic><topic>Molecular weight</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>NUB1</topic><topic>NUB1L</topic><topic>Oncology, Experimental</topic><topic>Phase transitions</topic><topic>Proliferating cell nuclear antigen</topic><topic>Protein binding</topic><topic>Protein research</topic><topic>Proteins</topic><topic>Review</topic><topic>Risk assessment</topic><topic>Transcription</topic><topic>Translational research</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><topic>Ubiquitin</topic><topic>Ubiquitins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arshad, Maria</creatorcontrib><creatorcontrib>Abdul Hamid, Nazefah</creatorcontrib><creatorcontrib>Chan, Mun Chiang</creatorcontrib><creatorcontrib>Ismail, Fuad</creatorcontrib><creatorcontrib>Tan, Geok Chin</creatorcontrib><creatorcontrib>Pezzella, Francesco</creatorcontrib><creatorcontrib>Tan, Ka-Liong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cells (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arshad, Maria</au><au>Abdul Hamid, Nazefah</au><au>Chan, Mun Chiang</au><au>Ismail, Fuad</au><au>Tan, Geok Chin</au><au>Pezzella, Francesco</au><au>Tan, Ka-Liong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective</atitle><jtitle>Cells (Basel, Switzerland)</jtitle><addtitle>Cells</addtitle><date>2021-08-24</date><risdate>2021</risdate><volume>10</volume><issue>9</issue><spage>2176</spage><pages>2176-</pages><issn>2073-4409</issn><eissn>2073-4409</eissn><abstract>Cancer increases the global disease burden substantially, but it remains a challenge to manage it. The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F-adjacent transcript 10 (FAT10) proteins as novel biomarkers in cancer. This literature review is based on the search of the electronic database, PubMed. NUB1 is an interferon-inducible protein that mediates apoptotic and anti-proliferative actions in cancer, while FAT10 is a ubiquitin-like modifier that promotes cancer. The upregulated expression of both NUB1 and FAT10 has been observed in various cancers. NUB1 protein binds to FAT10 non-covalently to promote FAT10 degradation. An overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest deficient 2 protein, causing chromosomal instability and breast tumourigenesis. FAT10 binds to the proliferating cell nuclear antigen protein and inhibits the DNA damage repair response. In addition, FAT10 involves epithelial-mesenchymal transition, invasion, apoptosis, and multiplication in hepatocellular carcinoma. Our knowledge about them is still limited. There is a need to further develop NUB1 and FAT10 as novel biomarkers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34571823</pmid><doi>10.3390/cells10092176</doi><orcidid>https://orcid.org/0000-0001-5811-8018</orcidid><orcidid>https://orcid.org/0000-0002-2289-7619</orcidid><orcidid>https://orcid.org/0000-0003-2779-8123</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cells (Basel, Switzerland), 2021-08, Vol.10 (9), p.2176 |
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| subjects | Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis B cells Biological markers Biological response modifiers biomarker Biomarkers Biomarkers, Tumor - metabolism Breast Breast cancer Cancer Cancer therapies Carcinogenesis - metabolism Carcinogenesis - pathology Cell cycle Cell Proliferation - physiology Chemical bonds Development and progression DNA damage DNA repair Enzymes FAT10 Gastric cancer Gene expression Genomic instability Hepatitis B Hepatocellular carcinoma Humans Inflammation Interferon Interferon-inducible protein Kinases Literature reviews Liver cancer Mesenchyme Molecular weight Neoplasms - metabolism Neoplasms - pathology NUB1 NUB1L Oncology, Experimental Phase transitions Proliferating cell nuclear antigen Protein binding Protein research Proteins Review Risk assessment Transcription Translational research Tumor necrosis factor-TNF Tumors Ubiquitin Ubiquitins - metabolism |
| title | NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective |
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