The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue
Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, ther...
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| Veröffentlicht in: | Biomedicines 2025-01, Vol.13 (1), p.186 |
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| creator | Johansson, Angelica Kalliara, Eirini Belfrage, Emma Alling, Teodor Pyl, Paul Theodor Gerdtsson, Anna Sandström Gullberg, Urban Porwit, Anna Drott, Kristina Ek, Sara |
| description | Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, there is a lack of specific markers for the progression from early to advanced stages of the disease. To address these challenges, the non-interventional BIO-MUSE trial was initiated. Here, we report on a case study involving one patient, where combined omics analysis of tissue and blood was used to reveal the unique molecular features associated with the progression of the disease.
We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. In addition, GeoMx-based digital spatial profiling of T-helper (CD3+/CD8-), T-cytotoxic (CD3+/CD8+), and CD163+ cells was performed on skin biopsies.
The results pinpoint targets, such as transforming growth factor β1, as some of the mechanisms underlying disease progression, which may have the potential to improve patient prognostication and the development of precision medicine efforts.
We propose that in patients with MF, the evolution of the malignant clone and the associated immune response need to be studied jointly to define relevant strategies for intervention. |
| doi_str_mv | 10.3390/biomedicines13010186 |
| format | Article |
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We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. In addition, GeoMx-based digital spatial profiling of T-helper (CD3+/CD8-), T-cytotoxic (CD3+/CD8+), and CD163+ cells was performed on skin biopsies.
The results pinpoint targets, such as transforming growth factor β1, as some of the mechanisms underlying disease progression, which may have the potential to improve patient prognostication and the development of precision medicine efforts.
We propose that in patients with MF, the evolution of the malignant clone and the associated immune response need to be studied jointly to define relevant strategies for intervention.</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><identifier>DOI: 10.3390/biomedicines13010186</identifier><identifier>PMID: 39857770</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibodies ; biomarker discovery ; Biomarkers ; Biopsy ; Case studies ; CD163 antigen ; CD3 antigen ; CD8 antigen ; Cells ; Clinical Medicine ; Clinical trials ; cutaneous T-cell lymphoma ; Cytotoxicity ; Disease ; Fungal infections ; Genomic analysis ; Genomics ; Immune response ; Klinisk medicin ; Life span ; Lymphocytes T ; Malignancy ; Medical and Health Sciences ; Medical prognosis ; Medical treatment ; Medicin och hälsovetenskap ; Mycosis ; Mycosis fungoides ; patient prognostication ; Patients ; Peripheral blood ; personalized medicine ; Precision medicine ; Reumatologi och inflammation ; Rheumatology and Autoimmunity ; Skin ; spatially resolved transcriptomics ; T cell receptors</subject><ispartof>Biomedicines, 2025-01, Vol.13 (1), p.186</ispartof><rights>2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2025 by the authors. 2025</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3666-1de2104b60b7314738dad27b842618ae469a1f5d5f2041f22fa1c9a4ae9cdb7d3</cites><orcidid>0000-0003-1717-0842 ; 0000-0003-1932-0365 ; 0000-0002-9350-7016 ; 0000-0002-1388-4912 ; 0000-0001-8772-0729 ; 0000-0002-7651-883X ; 0000-0003-1680-5666</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39857770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/59f8169a-5ba1-4373-91d9-1cf71a1ee12f$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Johansson, Angelica</creatorcontrib><creatorcontrib>Kalliara, Eirini</creatorcontrib><creatorcontrib>Belfrage, Emma</creatorcontrib><creatorcontrib>Alling, Teodor</creatorcontrib><creatorcontrib>Pyl, Paul Theodor</creatorcontrib><creatorcontrib>Gerdtsson, Anna Sandström</creatorcontrib><creatorcontrib>Gullberg, Urban</creatorcontrib><creatorcontrib>Porwit, Anna</creatorcontrib><creatorcontrib>Drott, Kristina</creatorcontrib><creatorcontrib>Ek, Sara</creatorcontrib><title>The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue</title><title>Biomedicines</title><addtitle>Biomedicines</addtitle><description>Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, there is a lack of specific markers for the progression from early to advanced stages of the disease. To address these challenges, the non-interventional BIO-MUSE trial was initiated. Here, we report on a case study involving one patient, where combined omics analysis of tissue and blood was used to reveal the unique molecular features associated with the progression of the disease.
We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. In addition, GeoMx-based digital spatial profiling of T-helper (CD3+/CD8-), T-cytotoxic (CD3+/CD8+), and CD163+ cells was performed on skin biopsies.
The results pinpoint targets, such as transforming growth factor β1, as some of the mechanisms underlying disease progression, which may have the potential to improve patient prognostication and the development of precision medicine efforts.
We propose that in patients with MF, the evolution of the malignant clone and the associated immune response need to be studied jointly to define relevant strategies for intervention.</description><subject>Antibodies</subject><subject>biomarker discovery</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Case studies</subject><subject>CD163 antigen</subject><subject>CD3 antigen</subject><subject>CD8 antigen</subject><subject>Cells</subject><subject>Clinical Medicine</subject><subject>Clinical trials</subject><subject>cutaneous T-cell lymphoma</subject><subject>Cytotoxicity</subject><subject>Disease</subject><subject>Fungal infections</subject><subject>Genomic analysis</subject><subject>Genomics</subject><subject>Immune response</subject><subject>Klinisk medicin</subject><subject>Life span</subject><subject>Lymphocytes T</subject><subject>Malignancy</subject><subject>Medical and Health Sciences</subject><subject>Medical prognosis</subject><subject>Medical treatment</subject><subject>Medicin och hälsovetenskap</subject><subject>Mycosis</subject><subject>Mycosis fungoides</subject><subject>patient prognostication</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>personalized medicine</subject><subject>Precision medicine</subject><subject>Reumatologi och inflammation</subject><subject>Rheumatology and Autoimmunity</subject><subject>Skin</subject><subject>spatially resolved transcriptomics</subject><subject>T cell receptors</subject><issn>2227-9059</issn><issn>2227-9059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNptkt9PFDEQxzdGIwT5D4xp4osvp522-6O-GDhBL-ECkeO56W5n93rZ3R7tVoL_jP-qhUMCxiaTTtrvfGY6nSx7C_Qj55J-qq0b0NjGjhiAU6BQFS-yfcZYOZM0ly-f-HvZYQgbmpYEXoF4ne1xWeVlWdL97PdqjeTCu85jCNaNxLVkedu4YAM5jWPnrMFAvkZvx46sPOppwHEiN3Zak6Xr9BB7-ysOuv5Mjsjx4ny2vLo8IXMdkFxO0dze8aaUYhUH54keDVkMQxyR_MCwdWOS2ZFcoLfbNXrdk-PeOXOvW9kQIr7JXrW6D3j4sB9kV6cnq_n32dn5t8X86GzW8KIoZmCQARV1QeuSgyh5ZbRhZV0JVkClURRSQ5ubvGVUQMtYq6GRWmiUjalLww-yxY5rnN6orbeD9rfKaavuD5zvlPaTbXpUWpRNTiXSO3xbMClTFlozxjUVlEJine1Y4Qa3sX5G6-M2WZ1MBVS5bCtIpam81qAEL7mSYKSCpi1BAyKwNuG-7HCJlT69Sf1PnXpGfX4z2rXq3E8FUBZQQJ4IHx4I3l1HDJMabGiw7_WILgbFIZcVpYLJJH3_j3Tjoh9T6-9VglY850kldqrGuxA8to_VAFV3A6r-N6Ap7N3TlzwG_R1H_gcboORn</recordid><startdate>20250114</startdate><enddate>20250114</enddate><creator>Johansson, Angelica</creator><creator>Kalliara, Eirini</creator><creator>Belfrage, Emma</creator><creator>Alling, Teodor</creator><creator>Pyl, Paul Theodor</creator><creator>Gerdtsson, Anna Sandström</creator><creator>Gullberg, Urban</creator><creator>Porwit, Anna</creator><creator>Drott, Kristina</creator><creator>Ek, Sara</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1717-0842</orcidid><orcidid>https://orcid.org/0000-0003-1932-0365</orcidid><orcidid>https://orcid.org/0000-0002-9350-7016</orcidid><orcidid>https://orcid.org/0000-0002-1388-4912</orcidid><orcidid>https://orcid.org/0000-0001-8772-0729</orcidid><orcidid>https://orcid.org/0000-0002-7651-883X</orcidid><orcidid>https://orcid.org/0000-0003-1680-5666</orcidid></search><sort><creationdate>20250114</creationdate><title>The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue</title><author>Johansson, Angelica ; 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However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, there is a lack of specific markers for the progression from early to advanced stages of the disease. To address these challenges, the non-interventional BIO-MUSE trial was initiated. Here, we report on a case study involving one patient, where combined omics analysis of tissue and blood was used to reveal the unique molecular features associated with the progression of the disease.
We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. In addition, GeoMx-based digital spatial profiling of T-helper (CD3+/CD8-), T-cytotoxic (CD3+/CD8+), and CD163+ cells was performed on skin biopsies.
The results pinpoint targets, such as transforming growth factor β1, as some of the mechanisms underlying disease progression, which may have the potential to improve patient prognostication and the development of precision medicine efforts.
We propose that in patients with MF, the evolution of the malignant clone and the associated immune response need to be studied jointly to define relevant strategies for intervention.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39857770</pmid><doi>10.3390/biomedicines13010186</doi><orcidid>https://orcid.org/0000-0003-1717-0842</orcidid><orcidid>https://orcid.org/0000-0003-1932-0365</orcidid><orcidid>https://orcid.org/0000-0002-9350-7016</orcidid><orcidid>https://orcid.org/0000-0002-1388-4912</orcidid><orcidid>https://orcid.org/0000-0001-8772-0729</orcidid><orcidid>https://orcid.org/0000-0002-7651-883X</orcidid><orcidid>https://orcid.org/0000-0003-1680-5666</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Antibodies biomarker discovery Biomarkers Biopsy Case studies CD163 antigen CD3 antigen CD8 antigen Cells Clinical Medicine Clinical trials cutaneous T-cell lymphoma Cytotoxicity Disease Fungal infections Genomic analysis Genomics Immune response Klinisk medicin Life span Lymphocytes T Malignancy Medical and Health Sciences Medical prognosis Medical treatment Medicin och hälsovetenskap Mycosis Mycosis fungoides patient prognostication Patients Peripheral blood personalized medicine Precision medicine Reumatologi och inflammation Rheumatology and Autoimmunity Skin spatially resolved transcriptomics T cell receptors |
| title | The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue |
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