Olivetol's Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia
Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing,...
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| Veröffentlicht in: | Biomedicines 2025-01, Vol.13 (1), p.183 |
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| creator | Zabolotneva, Anastasia A Popruga, Katerina E Makarov, Valentin V Yudin, Sergei M Gaponov, Andrei M Roumiantsev, Sergei A Shestopalov, Aleksandr V |
| description | Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions.
In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.
According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in
(-/-) mice, decreased serum glucose levels in
/
mice, improved lipid metabolism in
(-/-) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as
and
and depleting the representation of pathobionts such as
, although olivetol supplementation did not influence the diversity or richness of the communities.
These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects. |
| doi_str_mv | 10.3390/biomedicines13010183 |
| format | Article |
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In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.
According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in
(-/-) mice, decreased serum glucose levels in
/
mice, improved lipid metabolism in
(-/-) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as
and
and depleting the representation of pathobionts such as
, although olivetol supplementation did not influence the diversity or richness of the communities.
These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects.</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><identifier>DOI: 10.3390/biomedicines13010183</identifier><identifier>PMID: 39857767</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>alkylresorcinols ; Animal models ; Body weight ; Cholesterol ; db/db mice ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diet ; Dietary supplements ; Experiments ; Glucose ; Glucose metabolism ; High fat diet ; Hypercholesterolemia ; Hyperglycemia ; Insulin resistance ; Insulin secretion ; Intestinal microflora ; Laboratory animals ; Lipid metabolism ; Lipids ; Medical research ; metabolic disorders ; Metabolism ; Microbiota ; mouse gut microbiota ; Obesity ; olivetol ; Overweight ; Probiotics ; Quality of life ; R&D ; Research & development</subject><ispartof>Biomedicines, 2025-01, Vol.13 (1), p.183</ispartof><rights>2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2025 by the authors. 2025</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2871-b2e6e7678efc5dfc4565a32ef8205fb53b08cce548b79136bdbcdfdc8760e6c33</cites><orcidid>0000-0001-5389-7833 ; 0000-0002-7942-8004</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761620/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761620/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39857767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zabolotneva, Anastasia A</creatorcontrib><creatorcontrib>Popruga, Katerina E</creatorcontrib><creatorcontrib>Makarov, Valentin V</creatorcontrib><creatorcontrib>Yudin, Sergei M</creatorcontrib><creatorcontrib>Gaponov, Andrei M</creatorcontrib><creatorcontrib>Roumiantsev, Sergei A</creatorcontrib><creatorcontrib>Shestopalov, Aleksandr V</creatorcontrib><title>Olivetol's Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia</title><title>Biomedicines</title><addtitle>Biomedicines</addtitle><description>Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions.
In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.
According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in
(-/-) mice, decreased serum glucose levels in
/
mice, improved lipid metabolism in
(-/-) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as
and
and depleting the representation of pathobionts such as
, although olivetol supplementation did not influence the diversity or richness of the communities.
These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects.</description><subject>alkylresorcinols</subject><subject>Animal models</subject><subject>Body weight</subject><subject>Cholesterol</subject><subject>db/db mice</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Experiments</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>High fat diet</subject><subject>Hypercholesterolemia</subject><subject>Hyperglycemia</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Intestinal microflora</subject><subject>Laboratory animals</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Medical research</subject><subject>metabolic disorders</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>mouse gut microbiota</subject><subject>Obesity</subject><subject>olivetol</subject><subject>Overweight</subject><subject>Probiotics</subject><subject>Quality of life</subject><subject>R&D</subject><subject>Research & development</subject><issn>2227-9059</issn><issn>2227-9059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUstOXDEMvaqKChr4g6qK1EW7YNo87iurClFeEmgWpesoyXUgo8zNNMlFmh_qd9bMUARVs4gj5_jYPnZVvWf0ixCSfjU-rmDw1o-QmaCMsl68qQ44591c0ka-ffHer45yXlI8kome1e-qfSH7puva7qD6vQj-AUoMnzI5cw5sySSO5AaKNjF4S34UXYDocSAXUyE33qaIyYsm59Noi4-jDr5siMeYOGXAe4CAHI6cBL-Csei0IQsDGVHH5LvXBgpkTBAwbsrkdrMGwrYJ-PHWXKIn2fsYIBdIaFZeH1Z7TocMR092Vv08P7s9vZxfLy6uTk-u55b3HZsbDi1gXz042wzO1k3baMHB9Zw2zjTC0N5aaOredChGawZjBzfYvmsptFaIWXW14x2iXqp18issX0Xt1dYR053SqXgbQInaCSktZUB1LcUggdd9XUOrO82c1cj1bce1ngwOy6IWSYdXpK9_Rn-v7uKDYqxrWcspMnx-Ykjx14RyqJXPFpXTI6DYSrBGdlLy-hH68R_oMk4Jh7NDCSFaXJFZVe9QOMWcE7jnahhVj4ul_rdYGPbhZSfPQX_XSPwBrV3Pig</recordid><startdate>20250113</startdate><enddate>20250113</enddate><creator>Zabolotneva, Anastasia A</creator><creator>Popruga, Katerina E</creator><creator>Makarov, Valentin V</creator><creator>Yudin, Sergei M</creator><creator>Gaponov, Andrei M</creator><creator>Roumiantsev, Sergei A</creator><creator>Shestopalov, Aleksandr V</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5389-7833</orcidid><orcidid>https://orcid.org/0000-0002-7942-8004</orcidid></search><sort><creationdate>20250113</creationdate><title>Olivetol's Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia</title><author>Zabolotneva, Anastasia A ; Popruga, Katerina E ; Makarov, Valentin V ; Yudin, Sergei M ; Gaponov, Andrei M ; Roumiantsev, Sergei A ; Shestopalov, Aleksandr V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2871-b2e6e7678efc5dfc4565a32ef8205fb53b08cce548b79136bdbcdfdc8760e6c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>alkylresorcinols</topic><topic>Animal models</topic><topic>Body weight</topic><topic>Cholesterol</topic><topic>db/db mice</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Experiments</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>High fat diet</topic><topic>Hypercholesterolemia</topic><topic>Hyperglycemia</topic><topic>Insulin resistance</topic><topic>Insulin secretion</topic><topic>Intestinal microflora</topic><topic>Laboratory animals</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Medical research</topic><topic>metabolic disorders</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>mouse gut microbiota</topic><topic>Obesity</topic><topic>olivetol</topic><topic>Overweight</topic><topic>Probiotics</topic><topic>Quality of life</topic><topic>R&D</topic><topic>Research & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zabolotneva, Anastasia A</creatorcontrib><creatorcontrib>Popruga, Katerina E</creatorcontrib><creatorcontrib>Makarov, Valentin V</creatorcontrib><creatorcontrib>Yudin, Sergei M</creatorcontrib><creatorcontrib>Gaponov, Andrei M</creatorcontrib><creatorcontrib>Roumiantsev, Sergei A</creatorcontrib><creatorcontrib>Shestopalov, Aleksandr V</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biomedicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zabolotneva, Anastasia A</au><au>Popruga, Katerina E</au><au>Makarov, Valentin V</au><au>Yudin, Sergei M</au><au>Gaponov, Andrei M</au><au>Roumiantsev, Sergei A</au><au>Shestopalov, Aleksandr V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olivetol's Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia</atitle><jtitle>Biomedicines</jtitle><addtitle>Biomedicines</addtitle><date>2025-01-13</date><risdate>2025</risdate><volume>13</volume><issue>1</issue><spage>183</spage><pages>183-</pages><issn>2227-9059</issn><eissn>2227-9059</eissn><abstract>Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions.
In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.
According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in
(-/-) mice, decreased serum glucose levels in
/
mice, improved lipid metabolism in
(-/-) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as
and
and depleting the representation of pathobionts such as
, although olivetol supplementation did not influence the diversity or richness of the communities.
These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39857767</pmid><doi>10.3390/biomedicines13010183</doi><orcidid>https://orcid.org/0000-0001-5389-7833</orcidid><orcidid>https://orcid.org/0000-0002-7942-8004</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | alkylresorcinols Animal models Body weight Cholesterol db/db mice Diabetes Diabetes mellitus (insulin dependent) Diet Dietary supplements Experiments Glucose Glucose metabolism High fat diet Hypercholesterolemia Hyperglycemia Insulin resistance Insulin secretion Intestinal microflora Laboratory animals Lipid metabolism Lipids Medical research metabolic disorders Metabolism Microbiota mouse gut microbiota Obesity olivetol Overweight Probiotics Quality of life R&D Research & development |
| title | Olivetol's Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia |
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