Effect of CYP3A4 Inhibitors and Inducers on Pharmacokinetics and Pharmacodynamics of Saxagliptin and Active Metabolite M2 in Humans Using Physiological-Based Pharmacokinetic Combined DPP-4 Occupancy

We aimed to develop a physiological-based pharmacokinetic and dipepidyl peptidase 4 (DPP-4) occupancy model (PBPK-DO) characterized by two simultaneous simulations to predict pharmacokinetic (PK) and pharmacodynamic changes of saxagliptin and metabolite M2 in humans when coadministered with CYP3A4 i...

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Veröffentlicht in:	Frontiers in pharmacology 2021-10, Vol.12, p.746594-746594, Article 746594
Hauptverfasser:	Li, Gang, Yi, Bowen, Liu, Jingtong, Jiang, Xiaoquan, Pan, Fulu, Yang, Wenning, Liu, Haibo, Liu, Yang, Wang, Guopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	CYP3A4 DDI prediction DPP-4 occupancy Life Sciences & Biomedicine PBPK-DO model Pharmacology Pharmacology & Pharmacy saxagliptin Science & Technology
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