Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound

Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypog...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Frontiers in pharmacology 2021-10, Vol.12, p.714586-714586, Article 714586
Hauptverfasser: Le, Jiamei, Ji, Houlin, Zhou, Xiaoxiao, Wei, Xindong, Chen, Yifan, Fu, Yi, Ma, Yujie, Han, Qiuqin, Sun, Yongning, Gao, Yueqiu, Wu, Hailong
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 714586
container_issue
container_start_page 714586
container_title Frontiers in pharmacology
container_volume 12
creator Le, Jiamei
Ji, Houlin
Zhou, Xiaoxiao
Wei, Xindong
Chen, Yifan
Fu, Yi
Ma, Yujie
Han, Qiuqin
Sun, Yongning
Gao, Yueqiu
Wu, Hailong
description Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.
doi_str_mv 10.3389/fphar.2021.714586
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3389_fphar_2021_714586</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_8245ef4318204cca8cfc0ac7955350b2</doaj_id><sourcerecordid>2597484250</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhiMEolXpD-CWIxLN4m87F6TVQqFSgUrs3Zr4Y-sqsZc4KfTf19uUit7wxaOZed_RzFNVbzFaUaraD35_DeOKIIJXEjOuxIvqGAtBm1Zh8vKf-Kg6zfkGlUfblgr2ujqiTAqmhDiuzFVxGcCkPu3uzupt-hP-xhBt_c1N0KU-5KFOvv7pYkw5WFevz-p1KdpgQoS-vuohTs0nN4ZbZ-vvMM1jyW7SsE9ztG-qVx767E4f_5Nqe_55u_naXP74crFZXzaGMTI1QDiSVlFOkTASQCplLFccPBWt78B3UhAsKbPIOs-5Vd5TyzgC2rUY6El1sdjaBDd6P4YBxjudIOiHRBp3GsYpmN5pRRh3nlGsCGLGgDLeIDCy5Zxy1JHi9XHx2s_d4KxxcSobPTN9XonhWu_SrVa8XBaJYvDu0WBMv2aXJz2EbFxfDuXSnDXhrWSKlZVLK15azZhyHp1_GoORPqDWD6j1AbVeUBeNWjS_XZd8NsFF4550BbUkBTbDB-p4EyaYQoqbAmMq0vf_L6X36gK9Cw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2597484250</pqid></control><display><type>article</type><title>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Web of Science - Science Citation Index Expanded - 2021&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Le, Jiamei ; Ji, Houlin ; Zhou, Xiaoxiao ; Wei, Xindong ; Chen, Yifan ; Fu, Yi ; Ma, Yujie ; Han, Qiuqin ; Sun, Yongning ; Gao, Yueqiu ; Wu, Hailong</creator><creatorcontrib>Le, Jiamei ; Ji, Houlin ; Zhou, Xiaoxiao ; Wei, Xindong ; Chen, Yifan ; Fu, Yi ; Ma, Yujie ; Han, Qiuqin ; Sun, Yongning ; Gao, Yueqiu ; Wu, Hailong</creatorcontrib><description>Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.</description><identifier>ISSN: 1663-9812</identifier><identifier>EISSN: 1663-9812</identifier><identifier>DOI: 10.3389/fphar.2021.714586</identifier><identifier>PMID: 34764866</identifier><language>eng</language><publisher>LAUSANNE: Frontiers Media Sa</publisher><subject>dianthrone glycoside ; Life Sciences &amp; Biomedicine ; metabolism ; Pharmacology ; Pharmacology &amp; Pharmacy ; Science &amp; Technology ; sennoside A ; toxicology</subject><ispartof>Frontiers in pharmacology, 2021-10, Vol.12, p.714586-714586, Article 714586</ispartof><rights>Copyright © 2021 Le, Ji, Zhou, Wei, Chen, Fu, Ma, Han, Sun, Gao and Wu. 2021 Le, Ji, Zhou, Wei, Chen, Fu, Ma, Han, Sun, Gao and Wu</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>28</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000723994100001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</citedby><cites>FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</cites><orcidid>0000-0002-4776-1347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576406/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576406/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,39265,53798,53800</link.rule.ids></links><search><creatorcontrib>Le, Jiamei</creatorcontrib><creatorcontrib>Ji, Houlin</creatorcontrib><creatorcontrib>Zhou, Xiaoxiao</creatorcontrib><creatorcontrib>Wei, Xindong</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Fu, Yi</creatorcontrib><creatorcontrib>Ma, Yujie</creatorcontrib><creatorcontrib>Han, Qiuqin</creatorcontrib><creatorcontrib>Sun, Yongning</creatorcontrib><creatorcontrib>Gao, Yueqiu</creatorcontrib><creatorcontrib>Wu, Hailong</creatorcontrib><title>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</title><title>Frontiers in pharmacology</title><addtitle>FRONT PHARMACOL</addtitle><description>Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.</description><subject>dianthrone glycoside</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>metabolism</subject><subject>Pharmacology</subject><subject>Pharmacology &amp; Pharmacy</subject><subject>Science &amp; Technology</subject><subject>sennoside A</subject><subject>toxicology</subject><issn>1663-9812</issn><issn>1663-9812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>DOA</sourceid><recordid>eNqNkU1v1DAQhiMEolXpD-CWIxLN4m87F6TVQqFSgUrs3Zr4Y-sqsZc4KfTf19uUit7wxaOZed_RzFNVbzFaUaraD35_DeOKIIJXEjOuxIvqGAtBm1Zh8vKf-Kg6zfkGlUfblgr2ujqiTAqmhDiuzFVxGcCkPu3uzupt-hP-xhBt_c1N0KU-5KFOvv7pYkw5WFevz-p1KdpgQoS-vuohTs0nN4ZbZ-vvMM1jyW7SsE9ztG-qVx767E4f_5Nqe_55u_naXP74crFZXzaGMTI1QDiSVlFOkTASQCplLFccPBWt78B3UhAsKbPIOs-5Vd5TyzgC2rUY6El1sdjaBDd6P4YBxjudIOiHRBp3GsYpmN5pRRh3nlGsCGLGgDLeIDCy5Zxy1JHi9XHx2s_d4KxxcSobPTN9XonhWu_SrVa8XBaJYvDu0WBMv2aXJz2EbFxfDuXSnDXhrWSKlZVLK15azZhyHp1_GoORPqDWD6j1AbVeUBeNWjS_XZd8NsFF4550BbUkBTbDB-p4EyaYQoqbAmMq0vf_L6X36gK9Cw</recordid><startdate>20211026</startdate><enddate>20211026</enddate><creator>Le, Jiamei</creator><creator>Ji, Houlin</creator><creator>Zhou, Xiaoxiao</creator><creator>Wei, Xindong</creator><creator>Chen, Yifan</creator><creator>Fu, Yi</creator><creator>Ma, Yujie</creator><creator>Han, Qiuqin</creator><creator>Sun, Yongning</creator><creator>Gao, Yueqiu</creator><creator>Wu, Hailong</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4776-1347</orcidid></search><sort><creationdate>20211026</creationdate><title>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</title><author>Le, Jiamei ; Ji, Houlin ; Zhou, Xiaoxiao ; Wei, Xindong ; Chen, Yifan ; Fu, Yi ; Ma, Yujie ; Han, Qiuqin ; Sun, Yongning ; Gao, Yueqiu ; Wu, Hailong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>dianthrone glycoside</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>metabolism</topic><topic>Pharmacology</topic><topic>Pharmacology &amp; Pharmacy</topic><topic>Science &amp; Technology</topic><topic>sennoside A</topic><topic>toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le, Jiamei</creatorcontrib><creatorcontrib>Ji, Houlin</creatorcontrib><creatorcontrib>Zhou, Xiaoxiao</creatorcontrib><creatorcontrib>Wei, Xindong</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Fu, Yi</creatorcontrib><creatorcontrib>Ma, Yujie</creatorcontrib><creatorcontrib>Han, Qiuqin</creatorcontrib><creatorcontrib>Sun, Yongning</creatorcontrib><creatorcontrib>Gao, Yueqiu</creatorcontrib><creatorcontrib>Wu, Hailong</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le, Jiamei</au><au>Ji, Houlin</au><au>Zhou, Xiaoxiao</au><au>Wei, Xindong</au><au>Chen, Yifan</au><au>Fu, Yi</au><au>Ma, Yujie</au><au>Han, Qiuqin</au><au>Sun, Yongning</au><au>Gao, Yueqiu</au><au>Wu, Hailong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</atitle><jtitle>Frontiers in pharmacology</jtitle><stitle>FRONT PHARMACOL</stitle><date>2021-10-26</date><risdate>2021</risdate><volume>12</volume><spage>714586</spage><epage>714586</epage><pages>714586-714586</pages><artnum>714586</artnum><issn>1663-9812</issn><eissn>1663-9812</eissn><abstract>Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.</abstract><cop>LAUSANNE</cop><pub>Frontiers Media Sa</pub><pmid>34764866</pmid><doi>10.3389/fphar.2021.714586</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-4776-1347</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1663-9812
ispartof Frontiers in pharmacology, 2021-10, Vol.12, p.714586-714586, Article 714586
issn 1663-9812
1663-9812
language eng
recordid cdi_crossref_primary_10_3389_fphar_2021_714586
source DOAJ Directory of Open Access Journals; PubMed Central Open Access; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects dianthrone glycoside
Life Sciences & Biomedicine
metabolism
Pharmacology
Pharmacology & Pharmacy
Science & Technology
sennoside A
toxicology
title Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-07T00%3A02%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacology,%20Toxicology,%20and%20Metabolism%20of%20Sennoside%20A,%20A%20Medicinal%20Plant-Derived%20Natural%20Compound&rft.jtitle=Frontiers%20in%20pharmacology&rft.au=Le,%20Jiamei&rft.date=2021-10-26&rft.volume=12&rft.spage=714586&rft.epage=714586&rft.pages=714586-714586&rft.artnum=714586&rft.issn=1663-9812&rft.eissn=1663-9812&rft_id=info:doi/10.3389/fphar.2021.714586&rft_dat=%3Cproquest_cross%3E2597484250%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2597484250&rft_id=info:pmid/34764866&rft_doaj_id=oai_doaj_org_article_8245ef4318204cca8cfc0ac7955350b2&rfr_iscdi=true