Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound
Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypog...
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| Veröffentlicht in: | Frontiers in pharmacology 2021-10, Vol.12, p.714586-714586, Article 714586 |
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| container_title | Frontiers in pharmacology |
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| creator | Le, Jiamei Ji, Houlin Zhou, Xiaoxiao Wei, Xindong Chen, Yifan Fu, Yi Ma, Yujie Han, Qiuqin Sun, Yongning Gao, Yueqiu Wu, Hailong |
| description | Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism. |
| doi_str_mv | 10.3389/fphar.2021.714586 |
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Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.</description><identifier>ISSN: 1663-9812</identifier><identifier>EISSN: 1663-9812</identifier><identifier>DOI: 10.3389/fphar.2021.714586</identifier><identifier>PMID: 34764866</identifier><language>eng</language><publisher>LAUSANNE: Frontiers Media Sa</publisher><subject>dianthrone glycoside ; Life Sciences & Biomedicine ; metabolism ; Pharmacology ; Pharmacology & Pharmacy ; Science & Technology ; sennoside A ; toxicology</subject><ispartof>Frontiers in pharmacology, 2021-10, Vol.12, p.714586-714586, Article 714586</ispartof><rights>Copyright © 2021 Le, Ji, Zhou, Wei, Chen, Fu, Ma, Han, Sun, Gao and Wu. 2021 Le, Ji, Zhou, Wei, Chen, Fu, Ma, Han, Sun, Gao and Wu</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>29</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000723994100001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</citedby><cites>FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</cites><orcidid>0000-0002-4776-1347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576406/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576406/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids></links><search><creatorcontrib>Le, Jiamei</creatorcontrib><creatorcontrib>Ji, Houlin</creatorcontrib><creatorcontrib>Zhou, Xiaoxiao</creatorcontrib><creatorcontrib>Wei, Xindong</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Fu, Yi</creatorcontrib><creatorcontrib>Ma, Yujie</creatorcontrib><creatorcontrib>Han, Qiuqin</creatorcontrib><creatorcontrib>Sun, Yongning</creatorcontrib><creatorcontrib>Gao, Yueqiu</creatorcontrib><creatorcontrib>Wu, Hailong</creatorcontrib><title>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</title><title>Frontiers in pharmacology</title><addtitle>FRONT PHARMACOL</addtitle><description>Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. 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In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.</description><subject>dianthrone glycoside</subject><subject>Life Sciences & Biomedicine</subject><subject>metabolism</subject><subject>Pharmacology</subject><subject>Pharmacology & Pharmacy</subject><subject>Science & Technology</subject><subject>sennoside A</subject><subject>toxicology</subject><issn>1663-9812</issn><issn>1663-9812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>DOA</sourceid><recordid>eNqNkU1v1DAQhiMEolXpD-CWIxLN4m87F6TVQqFSgUrs3Zr4Y-sqsZc4KfTf19uUit7wxaOZed_RzFNVbzFaUaraD35_DeOKIIJXEjOuxIvqGAtBm1Zh8vKf-Kg6zfkGlUfblgr2ujqiTAqmhDiuzFVxGcCkPu3uzupt-hP-xhBt_c1N0KU-5KFOvv7pYkw5WFevz-p1KdpgQoS-vuohTs0nN4ZbZ-vvMM1jyW7SsE9ztG-qVx767E4f_5Nqe_55u_naXP74crFZXzaGMTI1QDiSVlFOkTASQCplLFccPBWt78B3UhAsKbPIOs-5Vd5TyzgC2rUY6El1sdjaBDd6P4YBxjudIOiHRBp3GsYpmN5pRRh3nlGsCGLGgDLeIDCy5Zxy1JHi9XHx2s_d4KxxcSobPTN9XonhWu_SrVa8XBaJYvDu0WBMv2aXJz2EbFxfDuXSnDXhrWSKlZVLK15azZhyHp1_GoORPqDWD6j1AbVeUBeNWjS_XZd8NsFF4550BbUkBTbDB-p4EyaYQoqbAmMq0vf_L6X36gK9Cw</recordid><startdate>20211026</startdate><enddate>20211026</enddate><creator>Le, Jiamei</creator><creator>Ji, Houlin</creator><creator>Zhou, Xiaoxiao</creator><creator>Wei, Xindong</creator><creator>Chen, Yifan</creator><creator>Fu, Yi</creator><creator>Ma, Yujie</creator><creator>Han, Qiuqin</creator><creator>Sun, Yongning</creator><creator>Gao, Yueqiu</creator><creator>Wu, Hailong</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4776-1347</orcidid></search><sort><creationdate>20211026</creationdate><title>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</title><author>Le, Jiamei ; Ji, Houlin ; Zhou, Xiaoxiao ; Wei, Xindong ; Chen, Yifan ; Fu, Yi ; Ma, Yujie ; Han, Qiuqin ; Sun, Yongning ; Gao, Yueqiu ; Wu, Hailong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-a2507d835306c7aa788cd585af369fbafb7621734d0def55d8ff3d450a3b91a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>dianthrone glycoside</topic><topic>Life Sciences & Biomedicine</topic><topic>metabolism</topic><topic>Pharmacology</topic><topic>Pharmacology & Pharmacy</topic><topic>Science & Technology</topic><topic>sennoside A</topic><topic>toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le, Jiamei</creatorcontrib><creatorcontrib>Ji, Houlin</creatorcontrib><creatorcontrib>Zhou, Xiaoxiao</creatorcontrib><creatorcontrib>Wei, Xindong</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Fu, Yi</creatorcontrib><creatorcontrib>Ma, Yujie</creatorcontrib><creatorcontrib>Han, Qiuqin</creatorcontrib><creatorcontrib>Sun, Yongning</creatorcontrib><creatorcontrib>Gao, Yueqiu</creatorcontrib><creatorcontrib>Wu, Hailong</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le, Jiamei</au><au>Ji, Houlin</au><au>Zhou, Xiaoxiao</au><au>Wei, Xindong</au><au>Chen, Yifan</au><au>Fu, Yi</au><au>Ma, Yujie</au><au>Han, Qiuqin</au><au>Sun, Yongning</au><au>Gao, Yueqiu</au><au>Wu, Hailong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound</atitle><jtitle>Frontiers in pharmacology</jtitle><stitle>FRONT PHARMACOL</stitle><date>2021-10-26</date><risdate>2021</risdate><volume>12</volume><spage>714586</spage><epage>714586</epage><pages>714586-714586</pages><artnum>714586</artnum><issn>1663-9812</issn><eissn>1663-9812</eissn><abstract>Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. 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| subjects | dianthrone glycoside Life Sciences & Biomedicine metabolism Pharmacology Pharmacology & Pharmacy Science & Technology sennoside A toxicology |
| title | Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound |
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