Advance in Drug Delivery for Ageing Skeletal Muscle
The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal mu...
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| Veröffentlicht in: | Frontiers in pharmacology 2020-07, Vol.11, p.1016-1016, Article 1016 |
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| container_title | Frontiers in pharmacology |
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| creator | Li, Yi Chen, Ming Zhao, Yanpeng Li, Ming Qin, Yong Cheng, Shi Yang, Yanyu Yin, Pengbin Zhang, Licheng Tang, Peifu |
| description | The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. However, the current clinical approaches to sarcopenia are limited. Recently, novel drug delivery systems offer new possibilities for treating aged muscle loss. Herein, we briefly recapitulate the potential therapeutic targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nano-carriers. Furthermore, we elaborately discuss the prospect of aged skeletal muscle treatment by nanotechnology approaches. |
| doi_str_mv | 10.3389/fphar.2020.01016 |
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It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. However, the current clinical approaches to sarcopenia are limited. Recently, novel drug delivery systems offer new possibilities for treating aged muscle loss. Herein, we briefly recapitulate the potential therapeutic targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nano-carriers. 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It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. However, the current clinical approaches to sarcopenia are limited. Recently, novel drug delivery systems offer new possibilities for treating aged muscle loss. Herein, we briefly recapitulate the potential therapeutic targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nano-carriers. Furthermore, we elaborately discuss the prospect of aged skeletal muscle treatment by nanotechnology approaches.</description><subject>ageing skeletal muscle</subject><subject>drug delivery</subject><subject>extracellular vesicle</subject><subject>Life Sciences & Biomedicine</subject><subject>Pharmacology</subject><subject>Pharmacology & Pharmacy</subject><subject>sarcopenia</subject><subject>Science & Technology</subject><subject>skeletal muscle regeneration</subject><issn>1663-9812</issn><issn>1663-9812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkcFvFCEUh4nR2Kb27nGOJmZX4LEMXEw226pNajyoZ8LAY0qdHVaYWdP_Xna3aexNLhB4v4_38hHyltElgNIfwu7O5iWnnC4po0y-IOdMSlhoxfjLf85n5LKUe1oXaA1SvCZnwFsALvQ5gbXf29FhE8fmKs99c4VD3GN-aELKzbrHOPbN91844GSH5utc3IBvyKtgh4KXj_sF-fnp-sfmy-L22-ebzfp24QToaeG9Vq2VnjsmHAPPJZPaWk9XGLrQAcfgvBCyY0CpkEE5jjowX2dRymsOF-TmxPXJ3ptdjlubH0yy0RwvUu6NzVOsHRkvhfPgkaqOCi3B-k4qK1ynWODShcr6eGLt5m6L3uE4ZTs8gz5_GeOd6dPetCCpErQC3j0Ccvo9Y5nMNhaHw2BHTHMxXHDdKtHqVS2lp1KXUykZw9M3jJqDOnNUZw7qzFFdjahT5A92KRQXsTp5ilV1q5WgXBwkUraJk51iGjdpHqcaff__UfgLqi6r6Q</recordid><startdate>20200708</startdate><enddate>20200708</enddate><creator>Li, Yi</creator><creator>Chen, Ming</creator><creator>Zhao, Yanpeng</creator><creator>Li, Ming</creator><creator>Qin, Yong</creator><creator>Cheng, Shi</creator><creator>Yang, Yanyu</creator><creator>Yin, Pengbin</creator><creator>Zhang, Licheng</creator><creator>Tang, Peifu</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5391-4477</orcidid><orcidid>https://orcid.org/0000-0002-6629-211X</orcidid></search><sort><creationdate>20200708</creationdate><title>Advance in Drug Delivery for Ageing Skeletal Muscle</title><author>Li, Yi ; Chen, Ming ; Zhao, Yanpeng ; Li, Ming ; Qin, Yong ; Cheng, Shi ; Yang, Yanyu ; Yin, Pengbin ; Zhang, Licheng ; Tang, Peifu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-dd987a6d2c14c13d26169aad05efbfb32efcd446b130046f8c2e9f1d10188d923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ageing skeletal muscle</topic><topic>drug delivery</topic><topic>extracellular vesicle</topic><topic>Life Sciences & Biomedicine</topic><topic>Pharmacology</topic><topic>Pharmacology & Pharmacy</topic><topic>sarcopenia</topic><topic>Science & Technology</topic><topic>skeletal muscle regeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Zhao, Yanpeng</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Qin, Yong</creatorcontrib><creatorcontrib>Cheng, Shi</creatorcontrib><creatorcontrib>Yang, Yanyu</creatorcontrib><creatorcontrib>Yin, Pengbin</creatorcontrib><creatorcontrib>Zhang, Licheng</creatorcontrib><creatorcontrib>Tang, Peifu</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yi</au><au>Chen, Ming</au><au>Zhao, Yanpeng</au><au>Li, Ming</au><au>Qin, Yong</au><au>Cheng, Shi</au><au>Yang, Yanyu</au><au>Yin, Pengbin</au><au>Zhang, Licheng</au><au>Tang, Peifu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advance in Drug Delivery for Ageing Skeletal Muscle</atitle><jtitle>Frontiers in pharmacology</jtitle><stitle>FRONT PHARMACOL</stitle><date>2020-07-08</date><risdate>2020</risdate><volume>11</volume><spage>1016</spage><epage>1016</epage><pages>1016-1016</pages><artnum>1016</artnum><issn>1663-9812</issn><eissn>1663-9812</eissn><abstract>The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. 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| subjects | ageing skeletal muscle drug delivery extracellular vesicle Life Sciences & Biomedicine Pharmacology Pharmacology & Pharmacy sarcopenia Science & Technology skeletal muscle regeneration |
| title | Advance in Drug Delivery for Ageing Skeletal Muscle |
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