Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer
Background: Alzheimer's disease (AD) manifests differently in males and females. However, the neuro-mechanism and influence factors are still unknown. Objective: To explore sex differences in brain network topology during AD disease progression and its association with cognition and possible in...
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| Veröffentlicht in: | Frontiers in aging neuroscience 2021-06, Vol.13, p.639529-639529, Article 639529 |
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| container_title | Frontiers in aging neuroscience |
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| creator | Li, Xiaoshu Zhou, ShanShan Zhu, Wanqiu Li, Xiaohu Gao, Ziwen Li, Meiqin Luo, Shilei Wu, Xingqi Tian, Yanghua Yu, Yongqiang |
| description | Background: Alzheimer's disease (AD) manifests differently in males and females. However, the neuro-mechanism and influence factors are still unknown.
Objective: To explore sex differences in brain network topology during AD disease progression and its association with cognition and possible influencing factors.
Methods: Resting-state functional magnetic resonance imaging (MRI) data and cognitive scores were collected from 82 AD patients (50 females), 56 amnestic mildly cognitive impaired patients (29 females), and 63 healthy controls (38 females). Global and regional topological network metrics and modular architecture were calculated. Two-way ANOVA was performed to explore group and sex interactions and their main effects. Mediation analysis was used to explore the relationship among education, inter/intra-network connectivity, and the Mini-Mental State Examination (MMSE) score.
Results: Lower levels of education, lower MMSE scores, and a positive correlation between the level of education and MMSE scores were found in female AD patients (p = 0.024, r = 0.319). Significantly lower connectivity strength within the sensorimotor network, dorsal attention network, ventral attention network (VAN), and between the sensorimotor and VAN were observed in male AD patients (p = 0.006, 0.028, 0.046, and 0.013, respectively). Group and sex interactions were also found in nodal properties, mainly in the frontal lobe, temporal lobe, middle cingulum, precuneus, and postcentral gyrus. Several of the altered brain network properties were associated with cognitive behavior in male AD patients. Education regulated the MMSE score through the mediation of connection strength between the default mode and limbic networks (LN) in the patient group (aMCI and AD combined).
Conclusion: Our results demonstrate that sex differences exist at the brain network level in AD. Sex differences in network topology and education are correlated with sex differences in cognition during AD progression. |
| doi_str_mv | 10.3389/fnagi.2021.639529 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3389_fnagi_2021_639529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e272e2296c8644d7a16948fb5eaad3df</doaj_id><sourcerecordid>2543706311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-5ae011fecb6549f9e3a127ae4000899a47b9990384370e6457da3309121db4e03</originalsourceid><addsrcrecordid>eNqNks1u1DAUhSMEolXpA7DzEgnN4L848QapSgtUqlokilhajnOdccnYg-20lDUPTjKpKio2eGPLPuezr-8pitcErxmr5Tvrde_WFFOyFkyWVD4rDokQbMWZKJ__tT4ojlO6wdNgDOOyflkcME64ZJIeFr-_wE906qyFCN4Ach5dQr4L8Tu6DrswhP4ead-hs240OrvgURNihEFn6NA3lzfoX0ATeu_22tMxOt-jvIFJkkAnQJ9jMJASChadDL824LYQXxUvrB4SHD_MR8XXD2fXzafVxdXH8-bkYmU4p3lVasCEWDCtKLm0EpgmtNLAp9JqKTWvWiklZjVnFQbBy6rTU8mSUNK1HDA7Ks4Xbhf0jdpFt9XxXgXt1H4jxF7pmJ0ZQAGtKFAqhakF512liZC8tm0JWnessxPr_cLaje0WOgM-Rz08gT498W6j-nCraoolo_Nj3jwAYvgxQspq65KBYdAewpgULecyBCNkkpJFamJIKYJ9vIZgNYdB7cOg5jCoJQyTp148d9AGm4ybu_Pom35MCErqspxzQRqX981twujzZH37_1b2B2DoyNY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2543706311</pqid></control><display><type>article</type><title>Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer</title><source>PubMed Central Free</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Li, Xiaoshu ; Zhou, ShanShan ; Zhu, Wanqiu ; Li, Xiaohu ; Gao, Ziwen ; Li, Meiqin ; Luo, Shilei ; Wu, Xingqi ; Tian, Yanghua ; Yu, Yongqiang</creator><creatorcontrib>Li, Xiaoshu ; Zhou, ShanShan ; Zhu, Wanqiu ; Li, Xiaohu ; Gao, Ziwen ; Li, Meiqin ; Luo, Shilei ; Wu, Xingqi ; Tian, Yanghua ; Yu, Yongqiang</creatorcontrib><description>Background: Alzheimer's disease (AD) manifests differently in males and females. However, the neuro-mechanism and influence factors are still unknown.
Objective: To explore sex differences in brain network topology during AD disease progression and its association with cognition and possible influencing factors.
Methods: Resting-state functional magnetic resonance imaging (MRI) data and cognitive scores were collected from 82 AD patients (50 females), 56 amnestic mildly cognitive impaired patients (29 females), and 63 healthy controls (38 females). Global and regional topological network metrics and modular architecture were calculated. Two-way ANOVA was performed to explore group and sex interactions and their main effects. Mediation analysis was used to explore the relationship among education, inter/intra-network connectivity, and the Mini-Mental State Examination (MMSE) score.
Results: Lower levels of education, lower MMSE scores, and a positive correlation between the level of education and MMSE scores were found in female AD patients (p = 0.024, r = 0.319). Significantly lower connectivity strength within the sensorimotor network, dorsal attention network, ventral attention network (VAN), and between the sensorimotor and VAN were observed in male AD patients (p = 0.006, 0.028, 0.046, and 0.013, respectively). Group and sex interactions were also found in nodal properties, mainly in the frontal lobe, temporal lobe, middle cingulum, precuneus, and postcentral gyrus. Several of the altered brain network properties were associated with cognitive behavior in male AD patients. Education regulated the MMSE score through the mediation of connection strength between the default mode and limbic networks (LN) in the patient group (aMCI and AD combined).
Conclusion: Our results demonstrate that sex differences exist at the brain network level in AD. Sex differences in network topology and education are correlated with sex differences in cognition during AD progression.</description><identifier>ISSN: 1663-4365</identifier><identifier>EISSN: 1663-4365</identifier><identifier>DOI: 10.3389/fnagi.2021.639529</identifier><identifier>PMID: 34149392</identifier><language>eng</language><publisher>LAUSANNE: Frontiers Media Sa</publisher><subject>Alzheimer’s disease ; cognitive reserve ; Geriatrics & Gerontology ; Life Sciences & Biomedicine ; modularity ; network topology ; Neuroscience ; Neurosciences ; Neurosciences & Neurology ; Science & Technology ; sex difference ; small-world property</subject><ispartof>Frontiers in aging neuroscience, 2021-06, Vol.13, p.639529-639529, Article 639529</ispartof><rights>Copyright © 2021 Li, Zhou, Zhu, Li, Gao, Li, Luo, Wu, Tian and Yu. 2021 Li, Zhou, Zhu, Li, Gao, Li, Luo, Wu, Tian and Yu</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000662185500001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c442t-5ae011fecb6549f9e3a127ae4000899a47b9990384370e6457da3309121db4e03</citedby><cites>FETCH-LOGICAL-c442t-5ae011fecb6549f9e3a127ae4000899a47b9990384370e6457da3309121db4e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209320/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209320/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27928,27929,53795,53797</link.rule.ids></links><search><creatorcontrib>Li, Xiaoshu</creatorcontrib><creatorcontrib>Zhou, ShanShan</creatorcontrib><creatorcontrib>Zhu, Wanqiu</creatorcontrib><creatorcontrib>Li, Xiaohu</creatorcontrib><creatorcontrib>Gao, Ziwen</creatorcontrib><creatorcontrib>Li, Meiqin</creatorcontrib><creatorcontrib>Luo, Shilei</creatorcontrib><creatorcontrib>Wu, Xingqi</creatorcontrib><creatorcontrib>Tian, Yanghua</creatorcontrib><creatorcontrib>Yu, Yongqiang</creatorcontrib><title>Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer</title><title>Frontiers in aging neuroscience</title><addtitle>FRONT AGING NEUROSCI</addtitle><description>Background: Alzheimer's disease (AD) manifests differently in males and females. However, the neuro-mechanism and influence factors are still unknown.
Objective: To explore sex differences in brain network topology during AD disease progression and its association with cognition and possible influencing factors.
Methods: Resting-state functional magnetic resonance imaging (MRI) data and cognitive scores were collected from 82 AD patients (50 females), 56 amnestic mildly cognitive impaired patients (29 females), and 63 healthy controls (38 females). Global and regional topological network metrics and modular architecture were calculated. Two-way ANOVA was performed to explore group and sex interactions and their main effects. Mediation analysis was used to explore the relationship among education, inter/intra-network connectivity, and the Mini-Mental State Examination (MMSE) score.
Results: Lower levels of education, lower MMSE scores, and a positive correlation between the level of education and MMSE scores were found in female AD patients (p = 0.024, r = 0.319). Significantly lower connectivity strength within the sensorimotor network, dorsal attention network, ventral attention network (VAN), and between the sensorimotor and VAN were observed in male AD patients (p = 0.006, 0.028, 0.046, and 0.013, respectively). Group and sex interactions were also found in nodal properties, mainly in the frontal lobe, temporal lobe, middle cingulum, precuneus, and postcentral gyrus. Several of the altered brain network properties were associated with cognitive behavior in male AD patients. Education regulated the MMSE score through the mediation of connection strength between the default mode and limbic networks (LN) in the patient group (aMCI and AD combined).
Conclusion: Our results demonstrate that sex differences exist at the brain network level in AD. Sex differences in network topology and education are correlated with sex differences in cognition during AD progression.</description><subject>Alzheimer’s disease</subject><subject>cognitive reserve</subject><subject>Geriatrics & Gerontology</subject><subject>Life Sciences & Biomedicine</subject><subject>modularity</subject><subject>network topology</subject><subject>Neuroscience</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Science & Technology</subject><subject>sex difference</subject><subject>small-world property</subject><issn>1663-4365</issn><issn>1663-4365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><sourceid>DOA</sourceid><recordid>eNqNks1u1DAUhSMEolXpA7DzEgnN4L848QapSgtUqlokilhajnOdccnYg-20lDUPTjKpKio2eGPLPuezr-8pitcErxmr5Tvrde_WFFOyFkyWVD4rDokQbMWZKJ__tT4ojlO6wdNgDOOyflkcME64ZJIeFr-_wE906qyFCN4Ach5dQr4L8Tu6DrswhP4ead-hs240OrvgURNihEFn6NA3lzfoX0ATeu_22tMxOt-jvIFJkkAnQJ9jMJASChadDL824LYQXxUvrB4SHD_MR8XXD2fXzafVxdXH8-bkYmU4p3lVasCEWDCtKLm0EpgmtNLAp9JqKTWvWiklZjVnFQbBy6rTU8mSUNK1HDA7Ks4Xbhf0jdpFt9XxXgXt1H4jxF7pmJ0ZQAGtKFAqhakF512liZC8tm0JWnessxPr_cLaje0WOgM-Rz08gT498W6j-nCraoolo_Nj3jwAYvgxQspq65KBYdAewpgULecyBCNkkpJFamJIKYJ9vIZgNYdB7cOg5jCoJQyTp148d9AGm4ybu_Pom35MCErqspxzQRqX981twujzZH37_1b2B2DoyNY</recordid><startdate>20210603</startdate><enddate>20210603</enddate><creator>Li, Xiaoshu</creator><creator>Zhou, ShanShan</creator><creator>Zhu, Wanqiu</creator><creator>Li, Xiaohu</creator><creator>Gao, Ziwen</creator><creator>Li, Meiqin</creator><creator>Luo, Shilei</creator><creator>Wu, Xingqi</creator><creator>Tian, Yanghua</creator><creator>Yu, Yongqiang</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210603</creationdate><title>Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer</title><author>Li, Xiaoshu ; Zhou, ShanShan ; Zhu, Wanqiu ; Li, Xiaohu ; Gao, Ziwen ; Li, Meiqin ; Luo, Shilei ; Wu, Xingqi ; Tian, Yanghua ; Yu, Yongqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5ae011fecb6549f9e3a127ae4000899a47b9990384370e6457da3309121db4e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer’s disease</topic><topic>cognitive reserve</topic><topic>Geriatrics & Gerontology</topic><topic>Life Sciences & Biomedicine</topic><topic>modularity</topic><topic>network topology</topic><topic>Neuroscience</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Science & Technology</topic><topic>sex difference</topic><topic>small-world property</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiaoshu</creatorcontrib><creatorcontrib>Zhou, ShanShan</creatorcontrib><creatorcontrib>Zhu, Wanqiu</creatorcontrib><creatorcontrib>Li, Xiaohu</creatorcontrib><creatorcontrib>Gao, Ziwen</creatorcontrib><creatorcontrib>Li, Meiqin</creatorcontrib><creatorcontrib>Luo, Shilei</creatorcontrib><creatorcontrib>Wu, Xingqi</creatorcontrib><creatorcontrib>Tian, Yanghua</creatorcontrib><creatorcontrib>Yu, Yongqiang</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in aging neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiaoshu</au><au>Zhou, ShanShan</au><au>Zhu, Wanqiu</au><au>Li, Xiaohu</au><au>Gao, Ziwen</au><au>Li, Meiqin</au><au>Luo, Shilei</au><au>Wu, Xingqi</au><au>Tian, Yanghua</au><au>Yu, Yongqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer</atitle><jtitle>Frontiers in aging neuroscience</jtitle><stitle>FRONT AGING NEUROSCI</stitle><date>2021-06-03</date><risdate>2021</risdate><volume>13</volume><spage>639529</spage><epage>639529</epage><pages>639529-639529</pages><artnum>639529</artnum><issn>1663-4365</issn><eissn>1663-4365</eissn><abstract>Background: Alzheimer's disease (AD) manifests differently in males and females. However, the neuro-mechanism and influence factors are still unknown.
Objective: To explore sex differences in brain network topology during AD disease progression and its association with cognition and possible influencing factors.
Methods: Resting-state functional magnetic resonance imaging (MRI) data and cognitive scores were collected from 82 AD patients (50 females), 56 amnestic mildly cognitive impaired patients (29 females), and 63 healthy controls (38 females). Global and regional topological network metrics and modular architecture were calculated. Two-way ANOVA was performed to explore group and sex interactions and their main effects. Mediation analysis was used to explore the relationship among education, inter/intra-network connectivity, and the Mini-Mental State Examination (MMSE) score.
Results: Lower levels of education, lower MMSE scores, and a positive correlation between the level of education and MMSE scores were found in female AD patients (p = 0.024, r = 0.319). Significantly lower connectivity strength within the sensorimotor network, dorsal attention network, ventral attention network (VAN), and between the sensorimotor and VAN were observed in male AD patients (p = 0.006, 0.028, 0.046, and 0.013, respectively). Group and sex interactions were also found in nodal properties, mainly in the frontal lobe, temporal lobe, middle cingulum, precuneus, and postcentral gyrus. Several of the altered brain network properties were associated with cognitive behavior in male AD patients. Education regulated the MMSE score through the mediation of connection strength between the default mode and limbic networks (LN) in the patient group (aMCI and AD combined).
Conclusion: Our results demonstrate that sex differences exist at the brain network level in AD. Sex differences in network topology and education are correlated with sex differences in cognition during AD progression.</abstract><cop>LAUSANNE</cop><pub>Frontiers Media Sa</pub><pmid>34149392</pmid><doi>10.3389/fnagi.2021.639529</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer’s disease cognitive reserve Geriatrics & Gerontology Life Sciences & Biomedicine modularity network topology Neuroscience Neurosciences Neurosciences & Neurology Science & Technology sex difference small-world property |
| title | Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer |
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