Statin Use May Be Associated With Reduced Active Tuberculosis Infection: A Meta-Analysis of Observational Studies
Background: Tuberculosis remains one of the leading causes of mortality among the infectious diseases, while statins were suggested to confer anti-infective efficacy in experimental studies. We aimed to evaluate the association between statin use and tuberculosis infection in a meta-analysis. Method...
Gespeichert in:
| Veröffentlicht in: | Frontiers in medicine 2020-04, Vol.7, p.121-121, Article 121 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 121 |
|---|---|
| container_issue | |
| container_start_page | 121 |
| container_title | Frontiers in medicine |
| container_volume | 7 |
| creator | Li, Xiaofei Sheng, Lina Lou, Lanqing |
| description | Background: Tuberculosis remains one of the leading causes of mortality among the infectious diseases, while statins were suggested to confer anti-infective efficacy in experimental studies. We aimed to evaluate the association between statin use and tuberculosis infection in a meta-analysis.
Method: Relevant studies were obtained via systematically search of PubMed and Embase databases. A random or a fixed effect model was applied to pool the results according to the heterogeneity among the included studies. Subgroup analyses according to the gender and diabetic status of the participants were performed. We assessed the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Results: Nine observational studies were included. Significant heterogeneity was detected among the studies (p for Cochrane's Q test |
| doi_str_mv | 10.3389/fmed.2020.00121 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3389_fmed_2020_00121</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_62262cd612a34921aaa58c31192f9a98</doaj_id><sourcerecordid>2401090732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-163151d6a4cfcdb35401b3c9148dbdc51d262085f45bcb6b6e307d56f4ad87943</originalsourceid><addsrcrecordid>eNqNkktr3DAUhUVpacI06-6KloXiiV7WWF0UnKGPgYRAk9DuhCxdJwoeK7HkKfPvK8-kQ7LrStI9n44e5yL0npI555U6bdfg5owwMieEMvoKHTOmZFGV1e_Xz-ZH6CTGe5IZzkpB-Vt0xBlXlEtxjB6vkkm-xzcR8IXZ4jPAdYzBepPA4V8-3eGf4EabF7VNfgP4emxgsGMXoo941beQy6H_jGt8AckUdW-67SSFFl82EYaNmXTT4as0Og_xHXrTmi7CydM4Qzffvl4vfxTnl99Xy_q8sKJUqaCS05I6aYRtrWt4KQhtuFVUVK5xNktMMlKVrSgb28hGAicLV8pWGFctlOAztNr7umDu9cPg12bY6mC83hXCcKvNkLztQEuWvayTlBkuFKPGmLKynFLFWmVUlb2-7L0exiZ_uoU-DaZ7YfpS6f2dvg0bvaBKECKzwccngyE8jhCTXvtooetMD2GMmuXXEUUWOZgZOt2jdggxDtAejqFET7nrKXc95a53uecdH57f7sD_SzkDn_bAH2hCG62H3sIBy51Rcp4bQ5Fdk8xQ9f_00qddvssw9on_Bdrdyk8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2401090732</pqid></control><display><type>article</type><title>Statin Use May Be Associated With Reduced Active Tuberculosis Infection: A Meta-Analysis of Observational Studies</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><creator>Li, Xiaofei ; Sheng, Lina ; Lou, Lanqing</creator><creatorcontrib>Li, Xiaofei ; Sheng, Lina ; Lou, Lanqing</creatorcontrib><description><![CDATA[Background: Tuberculosis remains one of the leading causes of mortality among the infectious diseases, while statins were suggested to confer anti-infective efficacy in experimental studies. We aimed to evaluate the association between statin use and tuberculosis infection in a meta-analysis.
Method: Relevant studies were obtained via systematically search of PubMed and Embase databases. A random or a fixed effect model was applied to pool the results according to the heterogeneity among the included studies. Subgroup analyses according to the gender and diabetic status of the participants were performed. We assessed the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Results: Nine observational studies were included. Significant heterogeneity was detected among the studies (p for Cochrane's Q test <0.001, I-2 = 93%). The GRADE approach showed generally low quality of evidence. Pooled results showed that statin use was associated with reduced active tuberculosis infection (risk ratio [RR]: 0.60, 95% confidence interval [CI]: 0.45 to 0.75, p < 0.001). Subgroup analyses showed that the negative association between statin use and active tuberculosis infection was consistent in men (RR: 0.63, p = 0.01) and women (RR: 0.58, p < 0.001), in participants with (RR: 0.63, p = 0.02) and without diabetes (RR: 0.50, p < 0.001), in retrospective cohort studies (RR: 0.56, p = 0.02), prospective cohort studies (RR: 0.76, p = 0.03), nested case-controls studies (RR: 0.57, p < 0.001), and case-control studies (RR: 0.60, p < 0.001), and in studies with statin used defined as any use within 1 year (RR: 0.59, p < 0.001) or during follow-up (RR: 0.61, p < 0.001). Significant publication bias was detected (p for Egger's regression test = 0.046). Subsequent "trim and fill" analyses retrieved an unpublished study to generate symmetrical funnel plots, and meta-analysis incorporating this study did not significantly affect the results (RR: 0.72, 95% CI: 0.68 to 0.76, p < 0.001).
Conclusions: Statin use may be associated with reduced active tuberculosis infection. Randomized controlled trials (RCTs) are needed to confirm the potential preventative role of statin use on tuberculosis infection.]]></description><identifier>ISSN: 2296-858X</identifier><identifier>EISSN: 2296-858X</identifier><identifier>DOI: 10.3389/fmed.2020.00121</identifier><identifier>PMID: 32391364</identifier><language>eng</language><publisher>LAUSANNE: Frontiers Media Sa</publisher><subject>diabetes ; General & Internal Medicine ; infection ; Life Sciences & Biomedicine ; Medicine ; Medicine, General & Internal ; meta-analysis ; Science & Technology ; statin ; tuberculosis</subject><ispartof>Frontiers in medicine, 2020-04, Vol.7, p.121-121, Article 121</ispartof><rights>Copyright © 2020 Li, Sheng and Lou.</rights><rights>Copyright © 2020 Li, Sheng and Lou. 2020 Li, Sheng and Lou</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000533413900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c459t-163151d6a4cfcdb35401b3c9148dbdc51d262085f45bcb6b6e307d56f4ad87943</citedby><cites>FETCH-LOGICAL-c459t-163151d6a4cfcdb35401b3c9148dbdc51d262085f45bcb6b6e307d56f4ad87943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194006/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194006/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,28255,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32391364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xiaofei</creatorcontrib><creatorcontrib>Sheng, Lina</creatorcontrib><creatorcontrib>Lou, Lanqing</creatorcontrib><title>Statin Use May Be Associated With Reduced Active Tuberculosis Infection: A Meta-Analysis of Observational Studies</title><title>Frontiers in medicine</title><addtitle>FRONT MED-LAUSANNE</addtitle><addtitle>Front Med (Lausanne)</addtitle><description><![CDATA[Background: Tuberculosis remains one of the leading causes of mortality among the infectious diseases, while statins were suggested to confer anti-infective efficacy in experimental studies. We aimed to evaluate the association between statin use and tuberculosis infection in a meta-analysis.
Method: Relevant studies were obtained via systematically search of PubMed and Embase databases. A random or a fixed effect model was applied to pool the results according to the heterogeneity among the included studies. Subgroup analyses according to the gender and diabetic status of the participants were performed. We assessed the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Results: Nine observational studies were included. Significant heterogeneity was detected among the studies (p for Cochrane's Q test <0.001, I-2 = 93%). The GRADE approach showed generally low quality of evidence. Pooled results showed that statin use was associated with reduced active tuberculosis infection (risk ratio [RR]: 0.60, 95% confidence interval [CI]: 0.45 to 0.75, p < 0.001). Subgroup analyses showed that the negative association between statin use and active tuberculosis infection was consistent in men (RR: 0.63, p = 0.01) and women (RR: 0.58, p < 0.001), in participants with (RR: 0.63, p = 0.02) and without diabetes (RR: 0.50, p < 0.001), in retrospective cohort studies (RR: 0.56, p = 0.02), prospective cohort studies (RR: 0.76, p = 0.03), nested case-controls studies (RR: 0.57, p < 0.001), and case-control studies (RR: 0.60, p < 0.001), and in studies with statin used defined as any use within 1 year (RR: 0.59, p < 0.001) or during follow-up (RR: 0.61, p < 0.001). Significant publication bias was detected (p for Egger's regression test = 0.046). Subsequent "trim and fill" analyses retrieved an unpublished study to generate symmetrical funnel plots, and meta-analysis incorporating this study did not significantly affect the results (RR: 0.72, 95% CI: 0.68 to 0.76, p < 0.001).
Conclusions: Statin use may be associated with reduced active tuberculosis infection. Randomized controlled trials (RCTs) are needed to confirm the potential preventative role of statin use on tuberculosis infection.]]></description><subject>diabetes</subject><subject>General & Internal Medicine</subject><subject>infection</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine, General & Internal</subject><subject>meta-analysis</subject><subject>Science & Technology</subject><subject>statin</subject><subject>tuberculosis</subject><issn>2296-858X</issn><issn>2296-858X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktr3DAUhUVpacI06-6KloXiiV7WWF0UnKGPgYRAk9DuhCxdJwoeK7HkKfPvK8-kQ7LrStI9n44e5yL0npI555U6bdfg5owwMieEMvoKHTOmZFGV1e_Xz-ZH6CTGe5IZzkpB-Vt0xBlXlEtxjB6vkkm-xzcR8IXZ4jPAdYzBepPA4V8-3eGf4EabF7VNfgP4emxgsGMXoo941beQy6H_jGt8AckUdW-67SSFFl82EYaNmXTT4as0Og_xHXrTmi7CydM4Qzffvl4vfxTnl99Xy_q8sKJUqaCS05I6aYRtrWt4KQhtuFVUVK5xNktMMlKVrSgb28hGAicLV8pWGFctlOAztNr7umDu9cPg12bY6mC83hXCcKvNkLztQEuWvayTlBkuFKPGmLKynFLFWmVUlb2-7L0exiZ_uoU-DaZ7YfpS6f2dvg0bvaBKECKzwccngyE8jhCTXvtooetMD2GMmuXXEUUWOZgZOt2jdggxDtAejqFET7nrKXc95a53uecdH57f7sD_SzkDn_bAH2hCG62H3sIBy51Rcp4bQ5Fdk8xQ9f_00qddvssw9on_Bdrdyk8</recordid><startdate>20200424</startdate><enddate>20200424</enddate><creator>Li, Xiaofei</creator><creator>Sheng, Lina</creator><creator>Lou, Lanqing</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200424</creationdate><title>Statin Use May Be Associated With Reduced Active Tuberculosis Infection: A Meta-Analysis of Observational Studies</title><author>Li, Xiaofei ; Sheng, Lina ; Lou, Lanqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-163151d6a4cfcdb35401b3c9148dbdc51d262085f45bcb6b6e307d56f4ad87943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>diabetes</topic><topic>General & Internal Medicine</topic><topic>infection</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine, General & Internal</topic><topic>meta-analysis</topic><topic>Science & Technology</topic><topic>statin</topic><topic>tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiaofei</creatorcontrib><creatorcontrib>Sheng, Lina</creatorcontrib><creatorcontrib>Lou, Lanqing</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiaofei</au><au>Sheng, Lina</au><au>Lou, Lanqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statin Use May Be Associated With Reduced Active Tuberculosis Infection: A Meta-Analysis of Observational Studies</atitle><jtitle>Frontiers in medicine</jtitle><stitle>FRONT MED-LAUSANNE</stitle><addtitle>Front Med (Lausanne)</addtitle><date>2020-04-24</date><risdate>2020</risdate><volume>7</volume><spage>121</spage><epage>121</epage><pages>121-121</pages><artnum>121</artnum><issn>2296-858X</issn><eissn>2296-858X</eissn><abstract><![CDATA[Background: Tuberculosis remains one of the leading causes of mortality among the infectious diseases, while statins were suggested to confer anti-infective efficacy in experimental studies. We aimed to evaluate the association between statin use and tuberculosis infection in a meta-analysis.
Method: Relevant studies were obtained via systematically search of PubMed and Embase databases. A random or a fixed effect model was applied to pool the results according to the heterogeneity among the included studies. Subgroup analyses according to the gender and diabetic status of the participants were performed. We assessed the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Results: Nine observational studies were included. Significant heterogeneity was detected among the studies (p for Cochrane's Q test <0.001, I-2 = 93%). The GRADE approach showed generally low quality of evidence. Pooled results showed that statin use was associated with reduced active tuberculosis infection (risk ratio [RR]: 0.60, 95% confidence interval [CI]: 0.45 to 0.75, p < 0.001). Subgroup analyses showed that the negative association between statin use and active tuberculosis infection was consistent in men (RR: 0.63, p = 0.01) and women (RR: 0.58, p < 0.001), in participants with (RR: 0.63, p = 0.02) and without diabetes (RR: 0.50, p < 0.001), in retrospective cohort studies (RR: 0.56, p = 0.02), prospective cohort studies (RR: 0.76, p = 0.03), nested case-controls studies (RR: 0.57, p < 0.001), and case-control studies (RR: 0.60, p < 0.001), and in studies with statin used defined as any use within 1 year (RR: 0.59, p < 0.001) or during follow-up (RR: 0.61, p < 0.001). Significant publication bias was detected (p for Egger's regression test = 0.046). Subsequent "trim and fill" analyses retrieved an unpublished study to generate symmetrical funnel plots, and meta-analysis incorporating this study did not significantly affect the results (RR: 0.72, 95% CI: 0.68 to 0.76, p < 0.001).
Conclusions: Statin use may be associated with reduced active tuberculosis infection. Randomized controlled trials (RCTs) are needed to confirm the potential preventative role of statin use on tuberculosis infection.]]></abstract><cop>LAUSANNE</cop><pub>Frontiers Media Sa</pub><pmid>32391364</pmid><doi>10.3389/fmed.2020.00121</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2296-858X |
| ispartof | Frontiers in medicine, 2020-04, Vol.7, p.121-121, Article 121 |
| issn | 2296-858X 2296-858X |
| language | eng |
| recordid | cdi_crossref_primary_10_3389_fmed_2020_00121 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central |
| subjects | diabetes General & Internal Medicine infection Life Sciences & Biomedicine Medicine Medicine, General & Internal meta-analysis Science & Technology statin tuberculosis |
| title | Statin Use May Be Associated With Reduced Active Tuberculosis Infection: A Meta-Analysis of Observational Studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T23%3A50%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Statin%20Use%20May%20Be%20Associated%20With%20Reduced%20Active%20Tuberculosis%20Infection:%20A%20Meta-Analysis%20of%20Observational%20Studies&rft.jtitle=Frontiers%20in%20medicine&rft.au=Li,%20Xiaofei&rft.date=2020-04-24&rft.volume=7&rft.spage=121&rft.epage=121&rft.pages=121-121&rft.artnum=121&rft.issn=2296-858X&rft.eissn=2296-858X&rft_id=info:doi/10.3389/fmed.2020.00121&rft_dat=%3Cproquest_cross%3E2401090732%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2401090732&rft_id=info:pmid/32391364&rft_doaj_id=oai_doaj_org_article_62262cd612a34921aaa58c31192f9a98&rfr_iscdi=true |