Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-kappa B/NLRP3 Pathway

Background: Oridonin (Ori), the main bioactive ingredient of the natural anti-inflammatory herb Rabdosia rubescens, could be a covalent inhibitor of the NLRP3 inflammasome. Solid organ transplantation provides a life-saving optional therapy for patients with end-stage organ dysfunction. The long-ter...

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Veröffentlicht in:	Frontiers in immunology 2021-09, Vol.12, p.719574-719574, Article 719574
Hauptverfasser:	Du, Xiaoxiao, Que, Weitao, Hu, Xin, Yu, Xiao, Guo, Wen-Zhi, Zhang, Shuijun, Li, Xiao-Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	acute rejection (AR) adaptive immune Allografts Animals BMDC cardiac transplantation Cytokines - metabolism Disease Models, Animal Diterpenes, Kaurane - pharmacology Graft Rejection Graft Survival - drug effects Graft Survival - immunology Heart Transplantation Immunology Inflammation Mediators - metabolism Life Sciences & Biomedicine Lymphocyte Activation Lymphocytes - immunology Lymphocytes - metabolism Lymphocytes - pathology Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Mice Models, Biological NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome oridonin Prognosis Science & Technology Signal Transduction - drug effects Treatment Outcome
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